88 research outputs found
Alpha-band rhythms in visual task performance: phase-locking by rhythmic sensory stimulation
Oscillations are an important aspect of neuronal activity. Interestingly, oscillatory patterns are also observed in behaviour, such as in visual performance measures after the presentation of a brief sensory event in the visual or another modality. These oscillations in visual performance cycle at the typical frequencies of brain rhythms, suggesting that perception may be closely linked to brain oscillations. We here investigated this link for a prominent rhythm of the visual system (the alpha-rhythm, 8-12 Hz) by applying rhythmic visual stimulation at alpha-frequency (10.6 Hz), known to lead to a resonance response in visual areas, and testing its effects on subsequent visual target discrimination. Our data show that rhythmic visual stimulation at 10.6 Hz: 1) has specific behavioral consequences, relative to stimulation at control frequencies (3.9 Hz, 7.1 Hz, 14.2 Hz), and 2) leads to alpha-band oscillations in visual performance measures, that 3) correlate in precise frequency across individuals with resting alpha-rhythms recorded over parieto-occipital areas. The most parsimonious explanation for these three findings is entrainment (phase-locking) of ongoing perceptually relevant alpha-band brain oscillations by rhythmic sensory events. These findings are in line with occipital alpha-oscillations underlying periodicity in visual performance, and suggest that rhythmic stimulation at frequencies of intrinsic brain-rhythms can be used to reveal influences of these rhythms on task performance to study their functional roles
Variable responses of human microbiomes to dietary supplementation with resistant starch
Abstract
Background
The fermentation of dietary fiber to various organic acids is a beneficial function provided by the microbiota in the human large intestine. In particular, butyric acid contributes to host health by facilitating maintenance of epithelial integrity, regulating inflammation, and influencing gene expression in colonocytes. We sought to increase the concentration of butyrate in 20 healthy young adults through dietary supplementation with resistant starch (unmodified potato starchâresistant starch (RS) type 2).
Methods
Fecal samples were collected from individuals to characterize butyrate concentration via liquid chromatography and composition of the microbiota via surveys of 16S rRNA-encoding gene sequences from the Illumina MiSeq platform. Random Forest and LEfSe analyses were used to associate responses in butyrate production to features of the microbiota.
Results
RS supplementation increased fecal butyrate concentrations in this cohort from 8 to 12 mmol/kg wet feces, but responses varied widely between individuals. Individuals could be categorized into three groups based upon butyrate concentrations before and during RS: enhanced, high, and low (nâ=â11, 3, and 6, respectively). Fecal butyrate increased by 67 % in the enhanced group (from 9 to 15 mmol/kg), while it remained â„11 mmol/kg in the high group and â€8 mmol/kg in the low group. Microbiota analyses revealed that the relative abundance of RS-degrading organismsâBifidobacterium adolescentis or Ruminococcus bromiiâincreased from ~2 to 9 % in the enhanced and high groups, but remained at ~1.5 % in the low group. The lack of increase in RS-degrading bacteria in the low group may explain why there was no increase in fecal butyrate in response to RS. The microbiota of individuals in the high group were characterized by an elevated abundance of the butyrogenic microbe Eubacterium rectale (~6 % in high vs. 3 % in enhanced and low groups) throughout the study.
Conclusions
We document the heterogeneous responses in butyrate concentrations upon RS supplementation and identify characteristic of the microbiota that appear to underlie this variation. This study complements and extends other studies that call for personalized approaches to manage beneficial functions provided by gut microbiomes.http://deepblue.lib.umich.edu/bitstream/2027.42/134598/1/40168_2016_Article_178.pd
Five supernova survey galaxies in the southern hemisphere. I. Optical and near-infrared database
The determination of the supernova (SN) rate is based not only on the number
of detected events, but also on the properties of the parent galaxy population.
This is the first paper of a series aimed at obtaining new, refined, SN rates
from a set of five SN surveys, by making use of a joint analysis of
near-infrared (NIR) data. We describe the properties of the 3838 galaxies that
were monitored for SNe events, including newly determined morphologies and
their DENIS and POSS-II/UKST I, 2MASS and DENIS J and Ks and 2MASS H
magnitudes. We have compared 2MASS, DENIS and POSS-II/UKST IJK magnitudes in
order to find possible systematic photometric shifts in the measurements. The
DENIS and POSS-II/UKST I band magnitudes show large discrepancies (mean
absolute difference of 0.4 mag), mostly due to different spectral responses of
the two instruments, with an important contribution (0.33 mag rms) from the
large uncertainties in the photometric calibration of the POSS-II and UKST
photographic plates. In the other wavebands, the limiting near infrared
magnitude, morphology and inclination of the galaxies are the most influential
factors which affect the determination of photometry of the galaxies.
Nevertheless, no significant systematic differences have been found between of
any pair of NIR magnitude measurements, except for a few percent of galaxies
showing large discrepancies. This allows us to combine DENIS and 2MASS data for
the J and Ks filters.Comment: 17 pages, 3 figures, 5 tables, published in Astrophysics, Vol. 52,
No. 1, 2009 (English translation of Astrofizika
Galactic and Extragalactic Samples of Supernova Remnants: How They Are Identified and What They Tell Us
Supernova remnants (SNRs) arise from the interaction between the ejecta of a
supernova (SN) explosion and the surrounding circumstellar and interstellar
medium. Some SNRs, mostly nearby SNRs, can be studied in great detail. However,
to understand SNRs as a whole, large samples of SNRs must be assembled and
studied. Here, we describe the radio, optical, and X-ray techniques which have
been used to identify and characterize almost 300 Galactic SNRs and more than
1200 extragalactic SNRs. We then discuss which types of SNRs are being found
and which are not. We examine the degree to which the luminosity functions,
surface-brightness distributions and multi-wavelength comparisons of the
samples can be interpreted to determine the class properties of SNRs and
describe efforts to establish the type of SN explosion associated with a SNR.
We conclude that in order to better understand the class properties of SNRs, it
is more important to study (and obtain additional data on) the SNRs in galaxies
with extant samples at multiple wavelength bands than it is to obtain samples
of SNRs in other galaxiesComment: Final 2016 draft of a chapter in "Handbook of Supernovae" edited by
Athem W. Alsabti and Paul Murdin. Final version available at
https://doi.org/10.1007/978-3-319-20794-0_90-
Cold gas accretion in galaxies
Evidence for the accretion of cold gas in galaxies has been rapidly
accumulating in the past years. HI observations of galaxies and their
environment have brought to light new facts and phenomena which are evidence of
ongoing or recent accretion:
1) A large number of galaxies are accompanied by gas-rich dwarfs or are
surrounded by HI cloud complexes, tails and filaments. It may be regarded as
direct evidence of cold gas accretion in the local universe. It is probably the
same kind of phenomenon of material infall as the stellar streams observed in
the halos of our galaxy and M31. 2) Considerable amounts of extra-planar HI
have been found in nearby spiral galaxies. While a large fraction of this gas
is produced by galactic fountains, it is likely that a part of it is of
extragalactic origin. 3) Spirals are known to have extended and warped outer
layers of HI. It is not clear how these have formed, and how and for how long
the warps can be sustained. Gas infall has been proposed as the origin. 4) The
majority of galactic disks are lopsided in their morphology as well as in their
kinematics. Also here recent accretion has been advocated as a possible cause.
In our view, accretion takes place both through the arrival and merging of
gas-rich satellites and through gas infall from the intergalactic medium (IGM).
The infall may have observable effects on the disk such as bursts of star
formation and lopsidedness. We infer a mean ``visible'' accretion rate of cold
gas in galaxies of at least 0.2 Msol/yr. In order to reach the accretion rates
needed to sustain the observed star formation (~1 Msol/yr), additional infall
of large amounts of gas from the IGM seems to be required.Comment: To appear in Astronomy & Astrophysics Reviews. 34 pages.
Full-resolution version available at
http://www.astron.nl/~oosterlo/accretionRevie
Neddylation inhibition upregulates PDâL1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149569/1/ijc32379_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149569/2/ijc32379-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149569/3/ijc32379.pd
The expansion field: The value of H_0
Any calibration of the present value of the Hubble constant requires
recession velocities and distances of galaxies. While the conversion of
observed velocities into true recession velocities has only a small effect on
the result, the derivation of unbiased distances which rest on a solid zero
point and cover a useful range of about 4-30 Mpc is crucial. A list of 279 such
galaxy distances within v<2000 km/s is given which are derived from the tip of
the red-giant branch (TRGB), from Cepheids, and from supernovae of type Ia (SNe
Ia). Their random errors are not more than 0.15 mag as shown by
intercomparison. They trace a linear expansion field within narrow margins from
v=250 to at least 2000 km/s. Additional 62 distant SNe Ia confirm the linearity
to at least 20,000 km/s. The dispersion about the Hubble line is dominated by
random peculiar velocities, amounting locally to <100 km/s but increasing
outwards. Due to the linearity of the expansion field the Hubble constant H_0
can be found at any distance >4.5 Mpc. RR Lyr star-calibrated TRGB distances of
78 galaxies above this limit give H_0=63.0+/-1.6 at an effective distance of 6
Mpc. They compensate the effect of peculiar motions by their large number.
Support for this result comes from 28 independently calibrated Cepheids that
give H_0=63.4+/-1.7 at 15 Mpc. This agrees also with the large-scale value of
H_0=61.2+/-0.5 from the distant, Cepheid-calibrated SNe Ia. A mean value of
H_0=62.3+/-1.3 is adopted. Because the value depends on two independent zero
points of the distance scale its systematic error is estimated to be 6%.
Typical errors of H_0 come from the use of a universal, yet unjustified P-L
relation of Cepheids, the neglect of selection bias in magnitude-limited
samples, or they are inherent to the adopted models.Comment: 44 pages, 4 figures, 6 tables, accepted for publication in the
Astronony and Astrophysics Review 15
Supernova remnants: the X-ray perspective
Supernova remnants are beautiful astronomical objects that are also of high
scientific interest, because they provide insights into supernova explosion
mechanisms, and because they are the likely sources of Galactic cosmic rays.
X-ray observations are an important means to study these objects.And in
particular the advances made in X-ray imaging spectroscopy over the last two
decades has greatly increased our knowledge about supernova remnants. It has
made it possible to map the products of fresh nucleosynthesis, and resulted in
the identification of regions near shock fronts that emit X-ray synchrotron
radiation.
In this text all the relevant aspects of X-ray emission from supernova
remnants are reviewed and put into the context of supernova explosion
properties and the physics and evolution of supernova remnants. The first half
of this review has a more tutorial style and discusses the basics of supernova
remnant physics and thermal and non-thermal X-ray emission. The second half
offers a review of the recent advances.The topics addressed there are core
collapse and thermonuclear supernova remnants, SN 1987A, mature supernova
remnants, mixed-morphology remnants, including a discussion of the recent
finding of overionization in some of them, and finally X-ray synchrotron
radiation and its consequences for particle acceleration and magnetic fields.Comment: Published in Astronomy and Astrophysics Reviews. This version has 2
column-layout. 78 pages, 42 figures. This replaced version has some minor
language edits and several references have been correcte
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