569 research outputs found
Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998–2012
During 1998–2012, an extended outbreak of Salmonella enterica serovar Typhimurium definitive type 160 (DT160) affected >3,000 humans and killed wild birds in New Zealand. However, the relationship between DT160 within these 2 host groups and the origin of the outbreak are unknown. Whole-genome sequencing was used to compare 109 Salmonella Typhimurium DT160 isolates from sources throughout New Zealand. We provide evidence that DT160 was introduced into New Zealand around 1997 and rapidly propagated throughout the country, becoming more genetically diverse over time. The genetic heterogeneity was evenly distributed across multiple predicted functional protein groups, and we found no evidence of host group differentiation between isolates collected from human, poultry, bovid, and wild bird sources, indicating ongoing transmission between these host groups. Our findings demonstrate how a comparative genomic approach can be used to gain insight into outbreaks, disease transmission, and the evolution of a multihost pathogen after a probable point-source introduction
Resolving the extragalactic hard X-ray background
The origin of the hard (2-10 keV) X-ray background has remained mysterious
for over 35 years. Most of the soft (0.5-2 keV) X-ray background has been
resolved into discrete sources, which are primarily quasars; however, these
sources do not have the flat spectral shape required to match the X-ray
background spectrum. Here we report the results of an X-ray survey 30 times
more sensitive than previous studies in the hard band and four times more
sensitive in the soft band. The sources detected in our survey account for at
least 75 per cent of the hard X-ray background. The mean X-ray spectrum of
these sources is in good agreement with that of the background. The X-ray
emission from the majority of the detected sources is unambiguously associated
with either the nuclei of otherwise normal bright galaxies or optically faint
sources, which could either be active nuclei of dust enshrouded galaxies or the
first quasars at very high redshifts.Comment: Nature article in pres
Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri
The development of systemic approaches in biology has put emphasis on
identifying genetic modules whose behavior can be modeled accurately so as to
gain insight into their structure and function. However most gene circuits in a
cell are under control of external signals and thus quantitative agreement
between experimental data and a mathematical model is difficult. Circadian
biology has been one notable exception: quantitative models of the internal
clock that orchestrates biological processes over the 24-hour diurnal cycle
have been constructed for a few organisms, from cyanobacteria to plants and
mammals. In most cases, a complex architecture with interlocked feedback loops
has been evidenced. Here we present first modeling results for the circadian
clock of the green unicellular alga Ostreococcus tauri. Two plant-like clock
genes have been shown to play a central role in Ostreococcus clock. We find
that their expression time profiles can be accurately reproduced by a minimal
model of a two-gene transcriptional feedback loop. Remarkably, best adjustment
of data recorded under light/dark alternation is obtained when assuming that
the oscillator is not coupled to the diurnal cycle. This suggests that coupling
to light is confined to specific time intervals and has no dynamical effect
when the oscillator is entrained by the diurnal cycle. This intringuing
property may reflect a strategy to minimize the impact of fluctuations in
daylight intensity on the core circadian oscillator, a type of perturbation
that has been rarely considered when assessing the robustness of circadian
clocks
Fluids in cosmology
We review the role of fluids in cosmology by first introducing them in
General Relativity and then by applying them to a FRW Universe's model. We
describe how relativistic and non-relativistic components evolve in the
background dynamics. We also introduce scalar fields to show that they are able
to yield an inflationary dynamics at very early times (inflation) and late
times (quintessence). Then, we proceed to study the thermodynamical properties
of the fluids and, lastly, its perturbed kinematics. We make emphasis in the
constrictions of parameters by recent cosmological probes.Comment: 34 pages, 4 figures, version accepted as invited review to the book
"Computational and Experimental Fluid Mechanics with Applications to Physics,
Engineering and the Environment". Version 2: typos corrected and references
expande
Silvopastoral systems as a tool for territorial sustainability and biodiversity
Rural and livestock population evolution in the inner north of Portugal
has demonstrated a great regression with consequences for environment and nature
conservation. In this context, and taking into account that pastoral activity has
shaped the natural areas of mountain territories since its beginning and that territories
are currently part of Natura 2000 network, rethinking the importance of such
activity has become vital. The constraints affecting daily tasks performed by shepherds
and livestock breeders as well as the installed social segregation are a strong
limitation. However, current research developed in the context of nature conservation
has demonstrated the importance of the landscape mosaic promoted by grazing
in the preservation of priority habitats. In this way, it is urgent to assess the issue of
shepherds and livestock breeders’ image in terms of their roles, relationships and
concerns, as well as to assess pastoralism socioeconomics in regard to self-consumption,
market and rural self-sufficiency. In this perspective, this work
presents an analysis of the adaptation of grazing to current times, perceiving its
limitations and success potential.This work is supported by European Structural and Investment Funds,
FEDER component, through the Operational Competitiveness and Internationalization Programme
(COMPETE 2020) [Project No. 006971 (UID/SOC/04011)], and national funds, through FCT,
Portuguese Foundation for Science and Technology under project UID/SOC/04011/2013.info:eu-repo/semantics/publishedVersio
CMB Telescopes and Optical Systems
The cosmic microwave background radiation (CMB) is now firmly established as
a fundamental and essential probe of the geometry, constituents, and birth of
the Universe. The CMB is a potent observable because it can be measured with
precision and accuracy. Just as importantly, theoretical models of the Universe
can predict the characteristics of the CMB to high accuracy, and those
predictions can be directly compared to observations. There are multiple
aspects associated with making a precise measurement. In this review, we focus
on optical components for the instrumentation used to measure the CMB
polarization and temperature anisotropy. We begin with an overview of general
considerations for CMB observations and discuss common concepts used in the
community. We next consider a variety of alternatives available for a designer
of a CMB telescope. Our discussion is guided by the ground and balloon-based
instruments that have been implemented over the years. In the same vein, we
compare the arc-minute resolution Atacama Cosmology Telescope (ACT) and the
South Pole Telescope (SPT). CMB interferometers are presented briefly. We
conclude with a comparison of the four CMB satellites, Relikt, COBE, WMAP, and
Planck, to demonstrate a remarkable evolution in design, sensitivity,
resolution, and complexity over the past thirty years.Comment: To appear in: Planets, Stars and Stellar Systems (PSSS), Volume 1:
Telescopes and Instrumentatio
Equilibrium configurations of two charged masses in General Relativity
An asymptotically flat static solution of Einstein-Maxwell equations which
describes the field of two non-extreme Reissner - Nordstr\"om sources in
equilibrium is presented. It is expressed in terms of physical parameters of
the sources (their masses, charges and separating distance). Very simple
analytical forms were found for the solution as well as for the equilibrium
condition which guarantees the absence of any struts on the symmetry axis. This
condition shows that the equilibrium is not possible for two black holes or for
two naked singularities. However, in the case when one of the sources is a
black hole and another one is a naked singularity, the equilibrium is possible
at some distance separating the sources. It is interesting that for
appropriately chosen parameters even a Schwarzschild black hole together with a
naked singularity can be "suspended" freely in the superposition of their
fields.Comment: 4 pages; accepted for publication in Phys. Rev.
Recommended from our members
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = -0.71 to -1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = -0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10-6, 1.7 × 10-9, 3.5 × 10-12 and 1.0 × 10-4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes
The microwave background temperature at the redshift of 2.33771
The Cosmic Microwave Background radiation is a fundamental prediction of Hot
Big Bang cosmology. The temperature of its black-body spectrum has been
measured at the present time, = 2.726 0.010 K, and is
predicted to have been higher in the past. At earlier time, the temperature can
be measured, in principle, using the excitation of atomic fine structure levels
by the radiation field. All previous measurements however give only upper
limits as they assume that no other significant source of excitation is
present. Here we report the detection of absorption from the first {\sl and}
second fine-structure levels of neutral carbon atoms in an isolated remote
cloud at a redshift of 2.33771. In addition, the unusual detection of molecular
hydrogen in several rotational levels and the presence of ionized carbon in its
excited fine structure level make the absorption system unique to constrain,
directly from observation, the different excitation processes at play. It is
shown for the first time that the cosmic radiation was warmer in the past. We
find 6.0 < T_{\rm CMBR} < 14 K at z = 2.33771 when 9.1 K is expected in the Hot
Big Bang cosmology.Comment: 20 pages, 5 figures, accepted for publication in Nature, Press
embargo until 1900 hrs London time (GMT) on 20 Dec 200
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