Alteration of Triassic carbonates in the Buda Mountains —a hydrothermal model

Abstract Large, irregular volumes of altered, friable Triassic dolomite with poorly recognizable depositional fabrics crop out in the Buda Mountains, Hungary. These rock volumes are characterized by powder-like, chalky, soft, whitish gray microporous carbonates, referred to as “pulverized dolomite”. This is interpreted as the result of corrosion of carbonates along microfractures. The pulverized dolomite is commonly associated with silica and clay cementation (“silicification”) and “mineralization” of ironrich minerals, barite, sphalerite, galena, fluorite, calcite, dolomite and others, clearly pointing out hydrothermal Mississippi Valley Type (MVT) conditions. The pulverization, silicification and mineralization are considered to be a diagenetic facies association (PSM facies). Tectonic shear corridors played an important role in the development of PSM facies as carriers of hydrothermal fluids, but the geometry of the altered units is very irregular and cross-cuts different Triassic depositional facies in addition to Eocene limestone and Middle-Upper Miocene sediments. The PSM facies represents the early stages of hydrothermal alteration (i.e. the burial phase) that was later modified by thermal mixing zones. Pulverized dolomite bodies that reached the surface were strongly affected by meteoric fluids; peculiar speleo-concretions were formed by calcite cementation of the powdery dolomite clasts. The altered carbonates show major porosity development whereas the unaltered carbonates present only minor porosity. The size and lithologic contrast of the altered geobodies makes them detectable by geophysical methods of mineral and hydrocarbon exploration

The s ---> d gamma decay in and beyond the Standard Model

The New Physics sensitivity of the s ---> d gamma transition and its accessibility through hadronic processes are thoroughly investigated. Firstly, the Standard Model predictions for the direct CP-violating observables in radiative K decays are systematically improved. Besides, the magnetic contribution to epsilon prime is estimated and found subleading, even in the presence of New Physics, and a new strategy to resolve its electroweak versus QCD penguin fraction is identified. Secondly, the signatures of a series of New Physics scenarios, characterized as model-independently as possible in terms of their underlying dynamics, are investigated by combining the information from all the FCNC transitions in the s ---> d sector.Comment: 54 pages, 14 eps figure

RNA Interference and Single Particle Tracking Analysis of Hepatitis C Virus Endocytosis

Hepatitis C virus (HCV) enters hepatocytes following a complex set of receptor interactions, culminating in internalization via clathrin-mediated endocytosis. However, aside from receptors, little is known about the cellular molecular requirements for infectious HCV entry. Therefore, we analyzed a siRNA library that targets 140 cellular membrane trafficking genes to identify host genes required for infectious HCV production and HCV pseudoparticle entry. This approach identified 16 host cofactors of HCV entry that function primarily in clathrin-mediated endocytosis, including components of the clathrin endocytosis machinery, actin polymerization, receptor internalization and sorting, and endosomal acidification. We next developed single particle tracking analysis of highly infectious fluorescent HCV particles to examine the co-trafficking of HCV virions with cellular cofactors of endocytosis. We observe multiple, sequential interactions of HCV virions with the actin cytoskeleton, including retraction along filopodia, actin nucleation during internalization, and migration of internalized particles along actin stress fibers. HCV co-localizes with clathrin and the ubiquitin ligase c-Cbl prior to internalization. Entering HCV particles are associated with the receptor molecules CD81 and the tight junction protein, claudin-1; however, HCV-claudin-1 interactions were not restricted to Huh-7.5 cell-cell junctions. Surprisingly, HCV internalization generally occurred outside of Huh-7.5 cell-cell junctions, which may reflect the poorly polarized nature of current HCV cell culture models. Following internalization, HCV particles transport with GFP-Rab5a positive endosomes, which is consistent with trafficking to the early endosome. This study presents technical advances for imaging HCV entry, in addition to identifying new host cofactors of HCV infection, some of which may be antiviral targets

HYPOPHOSPHOREMIE SEVERE APRES TRANSPLANTATION BIPULMONAIRE POUR MUCOVISCIDOSE (A PROPOS D'UN CAS)

REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Déficit acquis en facteur VIII : à propos d'un cas

REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

ABC Shadow algorithm: a tool for statistical analysis of spatial patterns

This paper presents an original ABC algorithm, ABC Shadow, that can be applied to sample posterior densities that are continuously differentiable. The proposed algorithm solves the main condition to be fulfilled by any ABC algorithm, in order to be useful in practice. This condition requires enough samples in the parameter space region, induced by the observed statistics. The algorithm is tuned on the posterior of a Gaussian model which is entirely known, and then, it is applied for the statistical analysis of several spatial patterns. These patterns are issued or assumed to be outcomes of point processes. The considered models are: Strauss, Candy and area-interaction.This work was initiated during stays of the first author at University Jaume I and INRA Avignon. The first author is grateful to D. Allard, Yu. Davydov, M. N. M. van Lieshout, J. Møller, E. Saar and the members of the Working Group “Stochastic Geometry” of the University of Lille, for useful comments and discussions. The work of the first author was partially supported by the GDR GEOSTO project. P. Gregori and J. Mateu were supported by Grants P1-1B2012- 52 and MTM2013-43917-P