Bestact – Software for Visualization of Digitalized Family Registers and Civil Status Acts

The introduction of new IT in public administration is a prerequisite for improving its efficiency and improving the administrative services. According to the legal requirements registers of civil status acts are formed for each municipality, stored in the territorial units Directorate "General Civil Registration and Administrative Services" for 130 years, then transferred to the State Archives. The oldest family registers are from the 1893 and their physical state in most municipalities is very bad. The logical outcome of the situation is the digitalization of these records. The software BestAct, developed by the author is planned, designed and developed to automate the handling of old family registers and civil status acts. Visualization of digitalized family registers and civil status has the ability to search by criteria. Keywords: IT, digitalization, registers and civil status acts, softwar

The new legal framework for public enterprises

The fast changing socio-economic conditions worldwide, the public the need to build a functioning market economy in our country, the need to harmonize Bulgarian legislation with that of the European Union have necessitated the adoption of an entirely new legal framework for public enterprises. Emphasis in the development is placed on the current and complex legislative changes introduced by the Public Enterprises Act and the Regulations for its implementation, which are guarantee for the improvement of the corporate governance of public enterprises, of the results in their financial condition, limiting the fiscal risks, as well as increasing the publicity and accountability of their management. In the end, conclusions are made about the application of the new legislation governing public enterprises

University education and the culture of social participation in Bulgaria

This research explores the unconscious processes that occurred on organizational as well as on individual level in an academic institution in Bulgaria when the task for liberalization of higher education system in the country has been set as university mission.Using a combination of action research and psycho-social methods this study focuses mainly on the implementation of four practical interventions in organizational culture that tended to increase the opportunities for more democratic, cooperative and caring relationships between its members. It has been assumed that such kind of change a) will facilitate the process of students’ personal development as socially engaged citizens in opposition to the traditional public passivity and conformity; b) will stimulate staff engagement with its values and mission creating balance with the more individualistic entrepreneurial tendencies in the organization, and c) will encourage more appreciative and supportive student – teacher relationships that could challenge the traditional authoritarian style of education in the country.The analysis of the data is done in this study when exploring three types of relations in the organization: a) the horizontal relations of collaboration within the academic community; b) the powerful hierarchical relations between the formal roles in the organization; and c) the learning relations between teachers and students. The findings demonstrate how a) under the pressures for fast change of role identities and habits during the transition period and b) in the presence of ‘discredited public relations in the mind’ raised during the socialism culture of relationships is co-created by the members that marginalizes the efforts for collaboration, evokes totalitarian type of leadership and deprives the process of learning and change. Some opportunities for overcoming such dynamics are seen in what Lowrence suggests as ‘politics of revelation’ and in the creation of informal spaces for individual and group reflection and dialogue

Specific post-operative nursing care in patients with a colostomy bag at a hospital

В настоящата работа са описани болестите, които налагат да се изведе изкуствен отвор и систематизирани видовете стоми, техните усложнения и мерките за предотвратяването им. Задачите, които си поставихме са: 1. Да се изготви алгоритъм за поставяне и смяна на колекторна система от медицинската сестра в болнично заведение. 2. Да се характеризират общите и специални следоперативни грижи при пациенти с колостома. От най-голямо значение в следоперативния период са качествените здравни грижи за колостомата и правилната смяна на колекторната система. Следоперативните грижи включват: хигиенни грижи, хранителен и двигателен режим, спазване правилата за асептика на оперативното поле, обучение на колостомирания болен за правилно самостоятелно сменяне на колекторната система, оказване на психологическа помощ не само на пациента, но и на неговите близки. Стоматерапията включва всички дейности по полагане грижи за стомата и е екипна дейност (участват лекар, психолог, медицинска сестра), но най-голяма роля за полагане грижи за стомата има медицинската сестра.The present work describes the diseases, which require the making of an ostomy and systematized types of stomas, their complications and measures to prevent them. The main targets of this work are: 1. Developing an algorithm for insertion and replacement of the collector system by the nurse at a hospital. 2. Characterizing general and special postoperative care in patients with a colostomy bag. The most important in the post-operative period are the quality health care for the colostomy bag and the correct change of the collector system. Post-operative care includes: hygiene care, observance of the rules for aseptic of the operating place, nutritional advice, physical activities, training of the patients with colostomy for proper self-replacement of the collector system, providing psychological assistance not only to the patients but also to their relatives. Stomatotherapy includes all stoma care activities and is a team work (surgeon, psychologist, nurse), but the nurse has the most important role in caring for the colostomy patient

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER- negative loci combined account for ~11% of familial relative risk for ER- negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction

Influence of Intragroup Dynamics and Intergroup Relations on Authenticity in Organizational and Social Contexts: A Review of Conceptual Framework and Research Evidence

Despite their shared focus on influence of groups on individual, research bridging intragroup dynamics and intergroup relations as predictors of authentic and inauthentic (self-alienated) experience, behavior and interaction of individuals in organizational and social contexts is surprisingly rare. The goal of the present article is to highlight how understanding the reciprocal dynamic relationship between intragroup processes and intergroup relations offers valuable new insights into both topics and suggests new, productive avenues for psychological theory, research and practice development – particularly for understanding and improving the intragroup and intergroup relations in groups, organizations and society affecting authentic psychosocial functioning. The article discusses the complementary role of intergroup and intragroup dynamics, reviewing how intergroup relations can affect intragroup dynamics which, in turn, affects the authenticity of individual experiences, behaviors and relations with others. The paper considers the implications, theoretical and practical, of the proposed reciprocal relationships between intragroup and intergroup processes as factors influencing authentic psychosocial functioning of individuals in organizational and social settings

VITREOPUPILLARY BLOCK AFTER INTRACAPSULAR CATARACT EXTRACTION

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Structural Dynamics and Catalytic Mechanism of ATP13A2 (PARK9) from Simulations

ATP13A2 is a gene encoding a protein of the P5B subfamily of ATPases and is a PARK gene. Molecular defects of the gene are mainly associated with variations of Parkinson’s disease (PD). Despite the established importance of the protein in regulating neuronal integrity, the three-dimensional structure of the protein currently remains unresolved crystallographically. We have modeled the structure and reactivity of the full-length protein in its E1-ATP state. Using molecular dynamics (MD), quantum cluster, and quantum mechanical/molecular mechanical (QM/MM) methods, we aimed at describing the main catalytic reaction, leading to the phosphorylation of Asp513. Our MD simulations suggest that two positively charged Mg2+ cations are present at the active site during the catalytic reaction, stabilizing a specific triphosphate binding mode. Using QM/MM calculations, we subsequently calculated the reaction profiles for the phosphoryl transfer step in the presence of one and two Mg2+ cations. The calculated barrier heights in both cases are found to be ∼12.5 and 7.5 kcal mol–1, respectively. We elucidated details of the catalytically competent ATP conformation and the binding mode of the second Mg2+ cofactor. We also examined the role of the conserved Arg686 and Lys859 catalytic residues. We observed that by significantly lowering the barrier height of the ATP cleavage reaction, Arg686 had major effect on the reaction. The removal of Arg686 increased the barrier height for the ATP cleavage by more than 5.0 kcal mol–1 while the removal of key electrostatic interactions created by Lys859 to the γ-phosphate and Asp513 destabilizes the reactant state. When missense mutations occur in close proximity to an active site residue, they can interfere with the barrier height of the reaction, which can halt the normal enzymatic rate of the protein. We also found large binding pockets in the full-length structure, including a transmembrane domain pocket, which is likely where the ATP13A2 cargo binds

Oblique stacking of three-dimensional dome islands in Ge/Si multilayers

The organization of Ge "dome" islands in Ge/Si multilayers has been investigated by cross-sectional transmission electron microscopy. Ge domes are found to spontaneously arrange in oblique stacks, replicating at a well-defined angle from one bilayer to the next. The formation of oblique island stacks is governed by a complex interplay of surface strain, generated by the already buried islands, and surface curvature, caused by the inherent tendency of large domes to carve out material from the surrounding planar substrate. (C) 2001 American Institute of Physics