Design, evaluation, and optimization of 3D printed truss scaffolds for bone tissue engineering

One of tissue engineering's main goals is to fabricate three-dimensional (3D) scaffolds with interconnected pores to reconstruct and regenerate damaged or deformed tissues and organs. In this regard, 3D printing is a promising technique for the fabrication of tissue scaffolds, which can precisely make predetermined and complicated architectures. This study aims to investigate and optimize the physical, mechanical, and biological properties of 3D truss architecture tissue scaffolds with different pore geometries. The mechanical properties of poly (methyl methacrylate) scaffolds are analysed experimentally and numerically. Furthermore, the mechanical and physical properties of scaffolds are optimized with response surface methodology (RSM), and cell adhesion of the 3D truss scaffold studies. Results demonstrate that mechanical properties of the simple and gradient scaffolds have different mechanical behaviors that are strongly correlated with pore size and their architectures, rather than merely the values of the porosity. It is also observed that the RSM technique can enable designers to enhance mechanical and physical properties of scaffolds at low cost. Moreover, the results of biological behaviour can endorse the reliability of 3D truss architecture in bone tissue engineering

Health Belief Model-based Intervention on Women's Knowledge and Perceived Beliefs about Warning Signs of Cancer

Objective: Early detection of cancers essentially depends on knowledge of the warning signs. This study, therefore, aimed at investigating the effect of Health Belief Model (HBM)-based educational intervention on the knowledge and perceived beliefs of women about the warning signs of cancer. Methods: This experimental study with intervention (n = 80) and control (n = 80) groups was performed at four urban health centers affiliated to the university. Data collection was done in two phases, before and one month after the educational intervention, using three instruments, a demographic-clinical information questionnaire, the awareness questionnaire on cancer warning signs, and the cancer warning signs-HBM questionnaire. Results: The results of the multivariate repeated-measures analyses of variance indicated that the hypothesis of this study was confirmed. It means that 'women's knowledge and their perceived beliefs of cancer warning signs' improved after HBM-based educational intervention in the intervention group, compared to the controls over time. Thus, the 'level of knowledge' and perceived beliefs of the women in the intervention group compared to the controls increased, in terms of perceived 'sensitivity,' 'severity,' 'benefits,' 'barriers,' 'cue to action,' and 'self-efficacy' over time (P < 0.001). Conclusions: It could be hoped that this intervention would be effective for improving the performance of women in health-promoting behaviors of cancer prevention. It is recommended that health-care providers plan for HBM-based educational interventions, based on educational needs of the target groups at different community levels