3 research outputs found
Individualised sensory intervention to improve quality of life in people with dementia and their companions (SENSE-Cog trial): study protocol for a randomised controlled trial
Background: Hearing and vision impairments are highly prevalent in people with dementia and may have a negative impact on quality of life and other dementia-related outcomes. Intervening to optimise sensory impairment and support sensory function may be a means of improving dementia-related outcomes. The SENSE-Cog trial will test whether a home-based multi-part sensory intervention is effective in improving quality of life and other key outcomes in people with dementia and hearing or vision problems (or both) and their companions. Methods: This is an European, multi-centre, observer-blind, pragmatic, randomised controlled trial. Three hundred fifty four people with dementia and hearing or vision impairment (or both) and their companions will be randomly assigned to receive either "care as usual" or a multi-component sensory intervention including assessment and correction of hearing or vision impairments (or both), home-based (maximum 10 visits over 18 weeks), therapist-delivered sensory support (that is, adherence to devices; improving the sensory environment (that is, lighting), communication training, and sign-posting to other support agencies). Change from baseline to intervention end (18 weeks) and post-intervention (36 weeks) will be compared between the two arms in the following outcomes: quality of life (primary endpoint), sensory and cognitive functional ability, relationships, mental well-being, health resource utilisation and cost-effectiveness. Discussion: This is one of two articles outlining the SENSE-Cog trial. Here, we describe the protocol for the effectiveness of the SENSE-Cog intervention. A parallel and complementary process evaluation will be described elsewhere. If the SENSE-Cog trial demonstrates that the sensory intervention improves outcomes in dementia, we will make a toolkit of training materials, resources and information available to health and social care providers to implement the intervention in routine practice. This will be a significant contribution to the therapeutic management of people with dementia and sensory impairment. Trial registration: ISRCTN (Trial ID: ISRCTN17056211) on 19 February 2018
Individualised sensory intervention to improve quality of life in people with dementia and their companions (SENSE-Cog trial): study protocol for a randomised controlled trial
BackgroundHearing and vision impairments are highly prevalent in people
with dementia and may have a negative impact on quality of life and
other dementia-related outcomes. Intervening to optimise sensory
impairment and support sensory function may be a means of improving
dementia-related outcomes. The SENSE-Cog trial will test whether a
home-based multi-part sensory intervention is effective in improving
quality of life and other key outcomes in people with dementia and
hearing or vision problems (or both) and their companions.MethodsThis is
anEuropean, multi-centre, observer-blind, pragmatic, randomised
controlled trial. Three hundred fifty four people with dementia and
hearing or vision impairment (or both) and their companions will be
randomly assigned to receive either care as usual or a multi-component
sensory intervention including assessment and correction of hearing or
vision impairments (or both), home-based (maximum 10 visits over
18weeks), therapist-delivered sensory support (that is, adherence to
devices; improving the sensory environment (that is, lighting),
communication training, and sign-posting to other support agencies).
Change from baseline to intervention end (18weeks) and post-intervention
(36weeks) will be compared between the two arms in the following
outcomes: quality of life (primary endpoint), sensory and cognitive
functional ability, relationships, mental well-being, health resource
utilisation and cost-effectiveness.DiscussionThis is one of two articles
outlining the SENSE-Cog trial. Here, we describe the protocol for the
effectiveness of the SENSE-Cog intervention. A parallel and
complementary process evaluation will be described elsewhere. If the
SENSE-Cog trial demonstrates that the sensory intervention improves
outcomes in dementia, we will make a toolkit of training materials,
resources and information available to health and social care providers
to implement the intervention in routine practice. This will be a
significant contribution to the therapeutic management of people with
dementia and sensory impairment.Trial registrationISRCTN (Trial ID:
ISRCTN17056211) on 19 February 2018
Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries
International audienceAbstract Introduction The Ebola virus disease (EVD) outbreak in 2014â2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine. Multiple questions regarding the safety, immunogenicity, and efficacy of EVD vaccines remain unanswered. To address these gaps in the evidence base, the Partnership for Research on Ebola Vaccines (PREVAC) trial was designed. This paper describes the design, methods, and baseline results of the PREVAC trial and discusses challenges that led to different protocol amendments. Methods This is a randomized, double-blind, placebo-controlled phase 2 clinical trial of three vaccine strategies against the Ebola virus in healthy volunteers 1âyear of age and above. The three vaccine strategies being studied are the rVSVÎG-ZEBOV-GP vaccine, with and without a booster dose at 56âdays, and the Ad26.ZEBOV,MVA-FN-Filo vaccine regimen with Ad26.ZEBOV given as the first dose and the MVA-FN-Filo vaccination given 56âdays later. There have been 4 versions of the protocol with those enrolled in Version 4.0 comprising the primary analysis cohort. The primary endpoint is based on the antibody titer against the Ebola virus surface glycoprotein measured 12âmonths following the final injection. Results From April 2017 to December 2018, a total of 5002 volunteers were screened and 4789 enrolled. Participants were enrolled at 6 sites in four countries (Guinea, Liberia, Sierra Leone, and Mali). Of the 4789 participants, 2560 (53%) were adults and 2229 (47%) were children. Those <â18âyears of age included 549 (12%) aged 1 to 4âyears, 750 (16%) 5 to 11âyears, and 930 (19%) aged 12â17âyears. At baseline, the median (25th, 75th percentile) antibody titer to Ebola virus glycoprotein for 1090 participants was 72 (50, 116) EU/mL. Discussion The PREVAC trial is evaluatingâplacebo-controlledâtwo promising Ebola candidate vaccines in advanced stages of development. The results will address unanswered questions related to short- and long-term safety and immunogenicity for three vaccine strategies in adults and children. Trial registration ClinicalTrials.gov NCT02876328 . Registered on 23 August 2016