Effects of high-intensity interval walking training on physical fitness and blood pressure in middle-aged and older people

Reproduced from Mayo Clin Proc., with permission), permission is hereby granted to place a pdf of Nemoto, K et al. Effects of high-intensity interval walking training on physical fitness and blood pressure in middle-aged and older people. Mayo Clin Proc. 82 (7):803-811 into the institutional repository of Shinshu University at https://soar-ir.shinshu-u.ac.jp/ArticleMAYO CLINIC PROCEEDINGS. 82(7): 803-811 (2007)journal articl

Science-based decision support for formulating crop fertilizer recommendations in sub-Saharan Africa

Open Access Article; Published online: 31 Jan 2020In sub-Saharan Africa, there is considerable spatial and temporal variability in relations between nutrient application and crop yield, due to varying inherent soil nutrients supply, soil moisture, crop management and germplasm. This variability affects fertilizer use efficiency and crop productivity. Therefore, development of decision systems that support formulation and delivery of site-specific fertilizer recommendations is important for increased crop yield and environmental protection. Nutrient Expert (NE) is a computer-based decision support system, which enables extension advisers to generate field- or area-specific fertilizer recommendations based on yield response to fertilizer and nutrient use efficiency. We calibrated NE for major maize agroecological zones in Nigeria, Ethiopia and Tanzania, with data generated from 735 on-farm nutrient omission trials conducted between 2015 and 2017. Between 2016 and 2018, 368 NE performance trials were conducted across the three countries in which recommendations generated with NE were evaluated relative to soil-test based recommendations, the current blanket fertilizer recommendations and a control with no fertilizer applied. Although maize yield response to fertilizer differed with geographic location; on average, maize yield response to nitrogen (N), phosphorus (P) and potassium (K) were respectively 2.4, 1.6 and 0.2 t ha−1 in Nigeria, 2.3, 0.9 and 0.2 t ha−1 in Ethiopia, and 1.5, 0.8 and 0.2 t ha−1 in Tanzania. Secondary and micronutrients increased maize yield only in specific areas in each country. Agronomic use efficiencies of N were 18, 22 and 13 kg grain kg−1 N, on average, in Nigeria, Ethiopia and Tanzania, respectively. In Nigeria, NE recommended lower amounts of P by 9 and 11 kg ha−1 and K by 24 and 38 kg ha−1 than soil-test based and regional fertilizer recommendations, respectively. Yet maize yield (4 t ha−1) was similar among the three methods. Agronomic use efficiencies of P and K (300 and 250 kg kg−1, respectively) were higher with NE than with the blanket recommendation (150 and 70 kg kg−1). In Ethiopia, NE and soil-test based respectively recommended lower amounts of P by 8 and 19 kg ha−1 than the blanket recommendations, but maize yield (6 t ha−1) was similar among the three methods. Overall, fertilizer recommendations generated with NE maintained high maize yield, but at a lower fertilizer input cost than conventional methods. NE was effective as a simple and cost-effective decision support tool for fine-tuning fertilizer recommendations to farm-specific conditions and offers an alternative to soil testing, which is hardly available to most smallholder farmers

Ecological Biogeography of West Usambara Mountains: A Study on the Influence of Abiotic Factors to Spatial Distribution of Plant and Animal Species

West Usambara Mountains, Tanzania are famous for rich biodiversity and endemic species of plants and animals. Although there have been extensive studies on plant and animals species, little attention has been given on abiotic factors influencing their spatial distribution. Given rampant degradation of vegetation and associated consequence on biodiversity, knowledge on abiotic factors influencing distribution of species along the landscape become pertinent for conservation. A study was carried out to explore abiotic factors impacting plant and animals species distribution. Soil, landform and land use/cover were studied using grids of 20 m × 20 m using FAO Guidelines for Soil Profile and Habitat Descriptions. Soils were described, sampled for laboratory analysis. Spatial distribution of plant species were determined in the grids, and along the transects, every time estimating the percent cover and describing the habitat. Distribution of animal species was studied using both small mammals and rodent burrows as proxies. Trapping was done using different traps sizes, checking daily for animal caught, counting and re-trapping. Rodent burrows were estimated in same grids by examining a width of 0.5 m from end to end of grid and total number of burrows recorded. Determination of species distribution was done using GLM regression. Results show that species are influenced by elevation, which was common to both plants and animals. Topsoil soil depth was positive to plant species whereas hillshade, surface stones, cultivation and atmospheric temperature were negatively influencing plant species. Rock outcrops, surface stones and cultivation were positively influencing small mammals distribution. It is concluded that factors influencing distribution of small mammals are elevation, surface stones, rock outcrop and cultivation. Factors influencing plant species are elevation soil depth whereas cultivation, hillshade, surface stone and rock out crops negatively impact distribution. For conservation, it is recommended that the best steps are to stop human activities leading to depletion of plant species and accelerating soil erosion and allow for self-regeneration. Control of soil erosion strongly recommended as way of plant species re-establishment

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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Cardiovascular control and stabilization via inclination and mobilization during bed rest

Cardiovascular deconditioning has long been recognized as a characteristic of the physiological adaptation to long-term bed rest in patients. The process is thought to contribute to orthostatic intolerance and enhance secondary complications in a significant way. Mobilization is a cost-effective and simple method to maintain the cardiovascular parameters (i.e., blood pressure, heart rate) stable, counter orthostatic intolerance and reduce the risk of secondary problems in patients during long-term immobilization. The aim of this project is to control the cardiovascular parameters such as heart rate and blood pressure of bed rest patients via automated leg mobilization and body tilting. In a first step, a nonlinear model predictive control strategy was designed and evaluated on five healthy subjects and 11 bed rest patients. In a next step, a clinically feasible study was conducted on two patients. The mean values differed on average less than 1 bpm from the predetermined heart rate and less than 2.5 mmHg from the desired blood pressure values. These results of the feasibility study are promising, although heterogeneous disease etiologies and individual medication strongly influence the mechanically induced reactions. The long-term goal is an automation of the control of physiological signals and the mobilization of bed rest patients in an early phase of the rehabilitation process. Therefore, this new approach could help to strengthen the cardiovascular system and prevent secondary health problems arising from long-term bed rest

Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis.

Osteoblasts express two key molecules for osteoclast differentiation, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG), a soluble decoy receptor for RANKL. RANKL induces osteoclastogenesis, while OPG inhibits it by blocking the binding of RANKL to RANK, a cellular receptor of RANKL. OPG-deficient (OPG–/–) mice exhibit severe alveolar bone loss with enhanced bone resorption. WP9QY (W9) peptide binds to RANKL and blocks RANKL-induced osteoclastogenesis. W9 is also reported to stimulate bone formation in vivo. Here, we show that treatment with W9 restores alveolar bone loss in OPG–/–mice by suppressing osteoclastogenesis and enhancing osteoblastogenesis. Administration of W9 or risedronate, a bisphosphonate, to OPG–/–mice significantly decreased the osteoclast number in the alveolar bone. Interestingly, treatment with W9, but not risedronate, enhanced Wnt/β-catenin signaling and induced alveolar bone formation in OPG–/–mice. Expression of sclerostin, an inhibitor of Wnt/β-catenin signaling, was significantly lower in tibiae of OPG–/–mice than in wild-type mice. Treatment with risedronate recovered sclerostin expression in OPG–/–mice, while W9 treatment further suppressed sclerostin expression. Histomorphometric analysis confirmed that bone formation-related parameters in OPG–/–mice, such as osteoblast number, osteoblast surface and osteoid surface, were increased by W9 administration but not by risedronate administration. These results suggest that treatment of OPG–/–mice with W9 suppressed osteoclastogenesis by inhibiting RANKL signaling and enhanced osteoblastogenesis by attenuating sclerostin expression in the alveolar bone. Taken together, W9 may be a useful drug to prevent alveolar bone loss in periodontitis

Factors influencing intensity of adoption of integrated water management innovations in the semi-arid areas of north-eastern, Tanzania

International Journal of Environmental Engineering and Natural Resources 2014: Vol. I(5): pp. 227-234The semi-arid areas of north-eastern Tanzania are faced by regular incidences of intra-seasonal dry spells which pose negatively impact on crop yields. The situation has forced farmers to practice different types of innovations including in situ capture and management of rainwater. collection, concentration, diversion and/or storage of run-off to mitigate the problems. This paper examines the main l'actors influencing intensity of adoption of water management innovations. The study was conducted through a cross-sectional survey in Makanya watershed. involving 234 farmers. Censored Tobit model was used to estimate the coefficients of intensity of adoption of the innovations. Intensity of adoption of the innovations was found to be between two and four. Most households (78.3%) had at least two innovations per plot, such as diversion canals. borders basin (sunken beds) and large planting pits. complimented with use of farm-yard manure, deep tillage. mulching and cover crops. The adoption intensity was higher in the uplands, with more than 56.7% of farmers having tour or more innovations in their farms compared to 30.8% and 41.7% in the lowlands and midlands, respectively. Group networking. years spent in formal education, respondent's age and agricultural information pathways were found to be the major factors influencing the adoption intensity at farm-level. Considering these factors in the scaling out of the innovations is expected to improve their adoption and thus intensify management of water resources in semi-arid watersheds with similar settings like Makanya. This is critical for an effective promotion of best practices of integrated water management systems at landscape level