A Albanese

A Khojasteh

A Piskin

A Temmerman

AB Dagum

AG Mason

AL Luís

BH Choi

C Firat

C Grothe

C Zheng

CC Wu

Constantinus Politis

D van Steenberghe

DD Ehrenfest

DH Whitman

DM Dohan

DM Dohan Ehrenfest

DM Hermann

DP Kuffler

E Anitua

E Emel

E Giannessi

F Graziani

F Mackenzie

F Ye

F Şenses

G Liang

G Terenghi

G Weibrich

GC Leitner

H Li

H Masuki

Hai-Yang Yu

HC Wang James

HH Cho

I Georgakopoulos

I Klineberg

Ivo Lambrichts

J Aerssens

J Choukroun

J Feine

J Javaloy

J Qin

JY Kim

K Nagata

K Nishida

K Unsicker

KM Chan

L dos Santos Corpas

L Küçük

L Ma

LM Wancket

M Corigliano

M Kazemi

M Lichtenfels

M Siemionow

M Sánchez

M Torabinejad

MA Malahias

MD Fabbro

Michael M Bornstein

N Zhang

P Gentile

P Habre-Hallage

Q Yuan

R Jacobs

RE Marx

Reinhilde Jacobs

RF Elgazzar

S Abbasipour-Dalivand

S Anjayani

S Graham

S Kaplan

S Werner

SK Mishra

SN Kaushik

T Burnouf

T Gordon

T Yamazaki

T Zhao

TY Farrag

U Hellman

V Moraschini

W Sulaiman

X Xie

XG Ding

Y Huang

Y Sariguney

International Journal of Oral Science

PubMed

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.We thank Mrs Bernadette Rawyler, medical illustrator, School of Dental Medicine, University of Bern, for the preparation of Figure 2. Fellowship support was received from Research Foundation Flanders (FWO) from the Belgian government and the Sichuan Province Science and Technology Support Program (2016SZ0010)

Huang, Yan

Bornstein, Michael M.

LAMBRICHTS, Ivo

Yu, Hai-Yang

POLITIS, Constantinus

Jacobs, Reinhilde

Document Server@UHasselt (Universiteit Hasselt)

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

Huang, Y

Bornstein, MM

Lambrichts, I

Yu, H-Y

Politis, C

Jacobs, R,

Swepub

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.International Journal of Oral Science advance online publication, 10 March 2017; doi:10.1038/ijos.2017.1.status: publishe

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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