Representation of Jews and Anti-Jewish Bias in 19th-Century French Public Discourse: Distant and Close Reading

We explore through the lens of distant reading the evolution of discourse on Jews in France during the XIX century. We analyze a large textual corpus including heterogeneous sources-literary works, periodicals, songs, essays, historical narratives-to trace how Jews are associated to different semantic domains, and how such associations shift over time. Our analysis deals with three key aspects of such changes: the overall transformation of embedding spaces, the trajectories of word associations, and the comparative projection of different religious groups over different, historically relevant semantic dimensions or streams of discourse. This allows to show changes in the association between words and semantic domains (referring e.g. to economic and moral behaviors), the evolution of stereotypes, and the dynamics of bias over a long time span characterized by major historical transformations. We suggest that the analysis of large textual corpora can be fruitfully used in a dialogue with more traditional close reading approaches-by pointing to opportunities of in-depth analyses that mobilize more qualitative approaches and a detailed inspection of the sources that distant reading inevitably tends to aggregate. We offer a short example of such a dialogue between different approaches in our discussion of the Second Empire transformations, where we mobilize the historian's tools to start disentangling the complex interactions between changes in French society, the nature of sources, and representations of Jews. While our example is limited in scope, we foresee large potential payoffs in the cooperative interaction between distant and close reading

The Ship of Theseus Puzzle

Does the Ship of Theseus present a genuine puzzle about persistence due to conflicting intuitions based on “continuity of form” and “continuity of matter” pulling in opposite directions? Philosophers are divided. Some claim that it presents a genuine puzzle but disagree over whether there is a solution. Others claim that there is no puzzle at all since the case has an obvious solution. To assess these proposals, we conducted a cross-cultural study involving nearly 3,000 people across twenty-two countries, speaking eighteen different languages. Our results speak against the proposal that there is no puzzle at all and against the proposal that there is a puzzle but one that has no solution. Our results suggest that there are two criteria—“continuity of form” and “continuity of matter”— that constitute our concept of persistence and these two criteria receive different weightings in settling matters concerning persistence

Reappraisal of the conventional hemostasis tests as predictors of perioperative bleeding in the era of rebalanced hemostasis in cirrhosis

New global laboratory procedures mimicking the in vivo hemostasis process led to the changing paradigm of cirrhosis from the prototype of hemorrhagic diseases to a condition in which hemostasis is normal but fragile, thus justifying the hemorrhagic/thrombotic tendencies that affect these patients. The new paradigm was instrumental to change the management of cirrhosis. For example, international guidelines warn against the entrenched practice of testing patients with conventional hemostasis tests and infusing those with abnormalities with fresh-frozen plasma, coagulation factor concentrates, or platelets, prior to surgery/invasive procedures. These recommendations are, however, largely disattended. The practice of testing patients with the prothrombin time or viscoelastometry and using arbitrary cutoffs to make decisions on perioperative prophylaxis is still common and probably driven by medicolegal issues. There is no doubt that prothrombin time and congeners tests are unable to predict bleeding in cirrhosis. However, it cannot be excluded that some tests may be useful in patients who are severely decompensated. Large prospective collaborative studies are warranted. Enrolled patients should be randomized to receive perioperative prophylaxis based on laboratory testing (eg, viscoelastometry, thrombomodulin-modified thrombin generation) or to usual care. However, for these trials to be useful, a third group of patients who do not receive prophylaxis should be included. In conclusion, until results from these studies are available, physicians attending cirrhosis should refrain from using laboratory tests with arbitrary cutoffs to make decision on perioperative prophylaxis. Decision should be made by considering the clinical history of individual patients and the risk of hemorrhage of specific procedures

Thirteen year experience of vitrectomy and air tamponade for primary retinal detachment repair with clinical outcomes

Purpose: To report outcomes of pars plana vitrectomy (PPV) with air tamponade for primary rhegmatogenous retinal detachment (RRD) and investigate the impact of vitreous cortex remnants (VCR) on surgical outcomes. Methods: A retrospective review of 900 patients treated for uncomplicated primary RRD between 2007 and 2020. Exclusion criteria included axial length > 26 mm, prior retinal surgery, giant retinal tear, PVR grade > B, and inadequate follow-up. Primary outcomes were retinal reattachment rate and best-corrected visual acuity (BCVA). Results: Of 900 patients, 397 met inclusion criteria. Primary reattachment rate was 88.4%, with significant BCVA improvement. Forty-six eyes experienced RRD recurrence. Complications included cataracts (38.8%), IOP rise (11.4%), and macular edema (8.3%). Better final BCVA was associated with preoperative macular non-involvement and absence of reinterventions. No significant association was found between RRD recurrence and various factors, including VCR removal. Conclusion: Air tamponade is a safe and effective option for primary RRD treatment. It has no negative effect on the environment and creates less discomfort for patients. VCR removal did not significantly reduce RRD recurrence in the overall number of cases. Further research will help determine the role of VCR in RD recurrence and define in which cases their removal might be beneficial

Targeting protein aggregation using a cocoa-bean shell extract to reduce α-synuclein toxicity in models of Parkinson's disease

Neurodegenerative diseases are among the major challenges in modern medicine, due to the progressive aging of the world population. Among these, Parkinson's disease (PD) affects 10 million people worldwide and is associated with the aggregation of the presynaptic protein α-synuclein (α-syn). Here we use two different PD models, yeast cells and neuroblastoma cells overexpressing α-syn, to investigate the protective effect of an extract from the cocoa shell, which is a by-product of the roasting process of cocoa beans. The LC-ESI-qTOF-MS and NMR analyses allow the identification of amino acids (including the essential ones), organic acids, lactate and glycerol, confirming also the presence of the two methylxanthines, namely caffeine and theobromine. The present study demonstrates that the supplementation with the cocoa bean shell extract (CBSE) strongly improves the longevity of yeast cells expressing α-syn, reducing the level of reactive oxygen species, activating autophagy and reducing the intracellular protein aggresomes. These anti-aggregation properties are confirmed also in neuroblastoma cells, where CBSE treatment leads to activation of AMPK kinase and to a significant reduction of toxic α-syn oligomers. Results obtained by surface plasmon resonance (SPR) assay highlights that CBSE binds α-syn protein in a concentration-dependent manner, supporting its inhibitory role on the amyloid aggregation of α-syn. These findings suggest that the supplementation with CBSE in the form of nutraceuticals may represent a promising way to prevent neurodegenerative diseases associated with α-syn aggregation

The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement

Background: The role of β-blockers in the critically ill has been studied, and data on the protective effects of these drugs on critically ill patients have been repeatedly reported in the literature over the last two decades. However, consensus and guidelines by scientific societies on the use of β-blockers in critically ill patients are still lacking. The purpose of this document is to support the clinical decision-making process regarding the use of β-blockers in critically ill patients. The recipients of this document are physicians, nurses, healthcare personnel, and other professionals involved in the patient's care process. Methods: The Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI) selected a panel of experts and asked them to define key aspects underlying the use of β-blockers in critically ill adult patients. The methodology followed by the experts during this process was in line with principles of modified Delphi and RAND-UCLA methods. The experts developed statements and supportive rationales in the form of informative text. The overall list of statements was subjected to blind votes for consensus. Results: The literature search suggests that adrenergic stress and increased heart rate in critically ill patients are associated with organ dysfunction and increased mortality. Heart rate control thus seems to be critical in the management of the critically ill patient, requiring careful clinical evaluation aimed at both the differential diagnosis to treat secondary tachycardia and the treatment of rhythm disturbance. In addition, the use of β-blockers for the treatment of persistent tachycardia may be considered in patients with septic shock once hypovolemia has been ruled out. Intravenous application should be the preferred route of administration. Conclusion: β-blockers protective effects in critically ill patients have been repeatedly reported in the literature. Their use in the acute treatment of increased heart rate requires understanding of the pathophysiology and careful differential diagnosis, as all causes of tachycardia should be ruled out and addressed first

Ultrasound—assisted periareolar oncoplastic approach in breast surgery: a focus on surgical technique

IntroductionBreast conservation surgery (BCS) combined with post-operative radiotherapy is the standard and preferred treatment for early-stage breast cancer (eBC), offering survival outcomes comparable to mastectomy while improving body image and quality of life. Oncoplastic breast surgery (OBS) has evolved from BCS to allow more extensive tissue removal while maintaining oncological safety and reducing the risk of post-surgical deformities. The ultrasound (US)-assisted periareolar approach in breast surgery offers several potential benefits, including reduced scarring, improved cosmetic outcomes, and enhanced surgical precision, particularly for non-palpable or small lesions, and potentially better nipple sensation preservation. This study aim to describe an US-assisted periareolar OBS approach for eBC patients with small to moderate breast ptosis.MethodsHere we present a focus on surgical technique consisting in OBS combining a US-assisted periareolar approach with volume displacement in small- to moderate- ptosic breasts. Margin resection adequacy, surgical complications and patient satisfaction using the Breast-Q questionnaire were assessed.ResultsThirty-two patients were considered. A negative margin of excision was achieved in all cases, and patients routinely received post-operative hypofractionated radiotherapy. Seroma was the most common complication (12.5%), while breast fat necrosis and minor wound infections occurred in 6% and 3% of cases, respectively. At a median follow-up of 12 months (range 6–18), post-treatment breast retraction occurred in 3 patients (9%), all of whom underwent fat grafting to improve outcomes. The average satisfaction score as determined by Breast-Q module was 78.6, rising to 81.3 for those who underwent contralateral mammaplasty.DiscussionThe combination of imaging, the use of oncoplastic surgical techniques and an appropriate post-operative management may provide the surgeon new tools for the treatment of eBC. In selected cases, the US-assisted periareolar oncoplastic approach is a versatile technique that can be easily adapted for tumors in any location of the breast

Primary cerebral alveolar rhabdomyosarcoma in adult

Primary cerebral rhabdomyosarcomas are very rare and malignant tumors that occur predominantly in the posterior fossa of pediatric patients. We report a rare case of primary cerebral rhabdomyosarcoma located in the supratentorial compartment of a 51 year-old woman together with a review of the pertinent Literature especially regarding the histological diagnosis and pitfalls