Inonotus obliquus attenuates histamine-induced microvascular inflammation.

Cell-to-cell communication is a key element of microvascular blood flow control, including rapidly carrying signals through the vascular endothelium in response to local stimuli. This cell-to-cell communication is negatively impacted during inflammation through the disruption of junctional integrity. Such disruption is associated with promoting the onset of cardiovascular diseases as a result of altered microvascular blood flow regulation. Therefore, understanding the mechanisms how inflammation drives microvascular dysfunction and compounds that mitigate such inflammation and dysfunction are of great interest for development. As such we aimed to investigate extracts of mushrooms as potential novel compounds. Using intravital microscopy, the medicinal mushroom, Inonotus obliquus was observed, to attenuate histamine-induced inflammation conducted vasodilation in second-order arterioles in the gluteus maximus muscle of C57BL/6 mice. Mast cell activation by C48/80 similarly disrupted endothelial junctions and conducted vasodilation but only histamine was blocked by the histamine antagonist, pyrilamine not C48/80 suggesting the importance of mast cell activation. Data presented here supports that histamine induced inflammation is a major disruptor of junctional integrity, and highlights the important anti-inflammatory properties of Inonotus obliquus focusing future assessment of mast cells as putative target for Inonotus obliquus

ropensci/piggyback: v0.1.4

<h2>What's Changed</h2> <ul> <li>Change default of <code>show_progress</code> to <code>interactive()</code> by @mrcaseb in https://github.com/ropensci/piggyback/pull/74</li> <li>handle empty tokens from gh::gh_token, resolves #77 by @tanho63 in https://github.com/ropensci/piggyback/pull/78</li> <li>fix bug in auth header by @tanho63 in https://github.com/ropensci/piggyback/pull/79</li> <li>simplify guess repo, closes #80 by @tanho63 in https://github.com/ropensci/piggyback/pull/82</li> <li>pb_release_delete + testing revamp by @tanho63 in https://github.com/ropensci/piggyback/pull/85</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/ropensci/piggyback/compare/v0.1.3...v0.1.4</p&gt

ropensci/piggyback: v0.1.2

<h2>What's Changed</h2> <ul> <li>fixup intro vignette to remove track/push/pull mentions by @tanho63 in https://github.com/ropensci/piggyback/pull/53</li> <li>Fix upload dir argument and cleanup intro vignette by @tanho63 in https://github.com/ropensci/piggyback/pull/56</li> <li>fix use_timestamps in pb_upload by @tanho63 in https://github.com/ropensci/piggyback/pull/57</li> <li>new release errors reported verbosely by @tanho63 in https://github.com/ropensci/piggyback/pull/59</li> <li>Refactoring of pb_list() and other changes by @tanho63 in https://github.com/ropensci/piggyback/pull/65</li> <li>Use verbose option by @tanho63 in https://github.com/ropensci/piggyback/pull/66</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/ropensci/piggyback/compare/v0.1.1...v0.1.2</p&gt

ropensci/piggyback: v0.1.3

<h2>What's Changed</h2> <ul> <li>Fix upload for releases with no existing assets by @tanho63 in https://github.com/ropensci/piggyback/pull/68</li> <li>Data frame subsetting works if tibble is not installed (closes #70). by @PMassicotte in https://github.com/ropensci/piggyback/pull/71</li> </ul> <h2>New Contributors</h2> <ul> <li>@PMassicotte made their first contribution in https://github.com/ropensci/piggyback/pull/71</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/ropensci/piggyback/compare/v0.1.2...v0.1.3</p&gt