Complete Singular Collineations and Quadrics

We construct wonderful compactifications of the spaces of linear maps and symmetric linear maps of a given rank as blowups of secant varieties of Segre and Veronese varieties. Furthermore, we investigate their birational geometry and their relations with some spaces of degree two stable maps

Ultrasonography of quadriceps femoris muscle and subcutaneous fat tissue and body composition by BIVA in chronic dialysis patients

Protein Energy Wasting (PEW) in hemodialysis (HD) patients is a multifactorial condition due to specific pathology-related pathogenetic mechanisms, leading to loss of skeletal muscle mass in HD patients. Computed Tomography and Magnetic Resonance Imaging still represent the gold standard techniques for body composition assessment. However, their widespread application in clinical practice is difficult and body composition evaluation in HD patients is mainly based on conventional anthropometric nutritional indexes and bioelectrical impedance vector analysis (BIVA). Little data is currently available on ultrasound (US)-based measurements of muscle mass and fat tissue in this clinical setting. The purpose of our study is to ascertain: (1) if there are differences between quadriceps rectus femoris muscle (QRFM) thickness and abdominal/thigh subcutaneous fat tissue (SFT) measured by US between HD patients and healthy subjects; (2) if there is any correlation between QRFM and abdominal/thigh SFT thickness by US, and BIVA/conventional nutritional indexes in HD patients. We enrolled 65 consecutive HD patients and 33 healthy subjects. Demographic and laboratory were collected. The malnutrition inflammation score (MIS) was calculated. Using B-mode US system, the QRFM and SFT thicknesses were measured at the level of three landmarks in both thighs (superior anterior iliac spine, upper pole of the patella, the midpoint of the tract included between the previous points). SFT was also measured at the level of the periumbilical point. The mono frequency (50 KHz) BIVA was conducted using bioelectrical measurements (Rz, resistance; Xc, reactance; adjusted for height, Rz/H and Xc/H; PA, phase angle). 58.5% were men and the mean age was 69 (SD 13.7) years. QRFM and thigh SFT thicknesses were reduced in HD patients as compared to healthy subjects (p < 0.01). Similarly, also BIVA parameters, expression of lean body mass, were lower (p < 0.001), except for Rz and Rz/H in HD patients. The average QRFM thickness of both thighs at top, mid, lower landmarks were positively correlated with PA and body cell mass (BCM) by BIVA, while negatively correlated with Rz/H (p < 0.05). Abdominal SFT was positively correlated with PA, BCM and basal metabolic rate (BMR) (p < 0.05). Our study shows that ultrasound QRFM and thigh SFT thicknesses were reduced in HD patients and that muscle ultrasound measurements were significantly correlated with BIVA parameters

Plasma and red blood cell pufas in home parenteral nutrition paediatric patients—effects of lipid emulsions

Background: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). Aim of the study: to assess glycerophosfolipid polyunsaturated fatty acids (PUFA) levels on plasma and red blood cell (RBC) membrane of children on long term PN with composite LE containing fish oil (SMOF), and to compare it with a group receiving olive oil LE (Clinoleic®) and to the reference range for age, previously determined on a group of healthy children. Results: A total of 38 patients were enrolled, median age 5.56 (0.9–21.86) years, 15 receiving Clinoleic®, 23 receiving SMOF. Patients on SMOF showed significantly higher levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower levels of arachidonic acid (ARA) and Mead acid (MEAD)/ARA ratio in plasma and RBC compared with patients on Clinoleic® and with healthy children. Triene:tetraene (T:T) ratio of both groups of patients did not differ from that of healthy children-median plasma (MEAD/ARA: 0.01, interquartile rage (IQR) 0.01, p = 0.61 and 0.02, IQR 0.02, p = 0.6 in SMOF and Clinoleic® patients, respectively), and was considerably lower than Holman index (>0.21). SMOF patients showed no statistically significant differences in growth parameters compared with Clinoleic® patients. Patients of both groups showed stiffness class F0-F1 of liver stiffness measure (LSM) 5.6 (IQR 0.85) in SMOF patients and 5.3 (IQR 0.90) in Clinoleic® patients, p = 0.58), indicating absence of liver fibrosis. Conclusions: Fatty acids, measured as concentrations (mg/L), revealed specific PUFA profile of PN patients and could be an accurate method to evaluate nutritional status and eventually to detect essential fatty acid deficiency (EFAD). SMOF patients showed significantly higher EPA, DHA and lower ARA concentrations compared to Clinoleic® patients. Both LEs showed similar hepatic evolution and growth

Il QB Stress Test e l'infermiere di dialisi: quanto basta per sorvegliare una fistola arterovenosa

Un accesso vascolare (AV) ben funzionante è la premessa necessaria per il buon esito di un trattamento dialitico. Il ruolo dell'infermiere nella sorveglianza e nel monitoraggio dell'AV è di fondamentale importanza sia nell'educazione del paziente sia nella prevenzione e nella precoce segnalazione delle complicanze. Nel nostro Centro abbiamo iniziato un protocollo mensile di misurazione della portata dell'AV attraverso l'utilizzo della metodica a diluizione a ultrasuoni, che tuttavia ha mostrato varie criticità per l'elevato numero di fistole arterovenose, la presenza di un unico strumento per più Centri, e la mal tolleranza dei pazienti per il cambio spesso necessario della posizione degli aghi e l'allungamento del tempo della seduta dialitica. Abbiamo quindi pensato di mettere a punto un test di pre-screening semplice e rapido, il QB stress test (QBST), che ci permettesse di selezionare solo quella popolazione a rischio da sottoporre a ulteriori accertamenti diagnostici. Dopo 5 anni di follow-up attraverso QBST ed esame clinico possiamo dire che il test è facile e veloce da eseguire ed è ben tollerato dai pazienti, ai quali non viene cambiata la posizione degli aghi né allungata la seduta dialitica. Inoltre nei pazienti negativi al test non abbiamo avuto nessun episodio trombotico

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)

The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jmedchem.9b00252. Experimental procedures, characterization of all intermediates and target compounds, and copies of NMR spectra of compounds 1, 39-57. Molecular formula strings of target compounds are available. ACKNOWLEDGEMENTS. We gratefully thank Signal Pharma and the Canadian Institutes of Health Research Proof of Principle grants PPP-125784 and PP2-139101 for financial support and fellowship (C.C.T), NIH grants R01DA039942, P30DA033934 and VCU School of Pharmacy start-up funds (A.H.L.). We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collection. We are grateful to Dr Monica Sani (CNR-ICRM, Milan, Italy) and Mr Massimo Frigerio (Politecnico di Milano, Italy) for the synthesis of two tetrazole-substituted indoles (Het-1 and Het-2)Peer reviewedPostprin

On the birational geometry of spaces of complete forms I: Collineations and quadrics

Moduli spaces of complete collineations are wonderful compactifications of spaces of linear maps of maximal rank between two fixed vector spaces. We investigate the birational geometry of moduli spaces of complete collineations and quadrics from the point of view of Mori theory. We compute their effective, nef and movable cones, the generators of their Cox rings, and their groups of pseudo-automorphisms. Furthermore, we give a complete description of both the Mori chamber and stable base locus decompositions of the effective cone of the space of complete collineations of the three-dimensional projective space

On Comon's and Strassen's conjectures

Comon's conjecture on the equality of the rank and the symmetric rank of a symmetric tensor, and Strassen's conjecture on the additivity of the rank of tensors are two of the most challenging and guiding problems in the area of tensor decomposition. We survey the main known results on these conjectures, and, under suitable bounds on the rank, we prove them, building on classical techniques used in the case of symmetric tensors, for mixed tensors. Finally, we improve the bound for Comon's conjecture given by flattenings by producing new equations for secant varieties of Veronese and Segre varieties

San Giorgio. Cenni storici

Descrizione della storia della chiesa di San Giorgio a Ferrar

L’arte di curare. Il processo per stregoneria contro Giovanna Pali (Modena, ottobre 1497- febbraio 1499)

Indagine della vicenda processuale di Giovanna Pali, cittadina modenese, alla fine del secolo XV. Appendice documentaria con pubblicazione di brani delle carte processuali, prima inedite