3,453 research outputs found
Electrodynamics of Amorphous Media at Low Temperatures
Amorphous solids exhibit intrinsic, local structural transitions, that give
rise to the well known quantum-mechanical two-level systems at low
temperatures. We explain the microscopic origin of the electric dipole moment
of these two-level systems: The dipole emerges as a result of polarization
fluctuations between near degenerate local configurations, which have nearly
frozen in at the glass transition. An estimate of the dipole's magnitude, based
on the random first order transition theory, is obtained and is found to be
consistent with experiment. The interaction between the dipoles is estimated
and is shown to contribute significantly to the Gr\"{u}neisen parameter anomaly
in low glasses. In completely amorphous media, the dipole moments are
expected to be modest in size despite their collective origin. In partially
crystalline materials, however, very large dipoles may arise, possibly
explaining the findings of Bauer and Kador, J. Chem. Phys. {\bf 118}, 9069
(2003).Comment: Submitted for publication; April 27, 2005 versio
Correcting the z~8 Galaxy Luminosity Function for Gravitational Lensing Magnification Bias
We present a Bayesian framework to account for the magnification bias from
both strong and weak gravitational lensing in estimates of high-redshift galaxy
luminosity functions. We illustrate our method by estimating the UV
luminosity function using a sample of 97 Y-band dropouts (Lyman break galaxies)
found in the Brightest of Reionizing Galaxies (BoRG) survey and from the
literature. We find the luminosity function is well described by a Schechter
function with characteristic magnitude of ,
faint-end slope of , and number density of
. These
parameters are consistent within the uncertainties with those inferred from the
same sample without accounting for the magnification bias, demonstrating that
the effect is small for current surveys at , and cannot account for the
apparent overdensity of bright galaxies compared to a Schechter function found
recently by Bowler et al. (2014a,b) and Finkelstein et al. (2014). We estimate
that the probability of finding a strongly lensed source in our sample
is in the range depending on limiting magnitude. We identify one
strongly-lensed candidate and three cases of intermediate lensing in BoRG
(estimated magnification ) in addition to the previously known
candidate group-scale strong lens. Using a range of theoretical luminosity
functions we conclude that magnification bias will dominate wide field surveys
-- such as those planned for the Euclid and WFIRST missions -- especially at
. Magnification bias will need to be accounted for in order to derive
accurate estimates of high-redshift luminosity functions in these surveys and
to distinguish between galaxy formation models.Comment: Accepted for publication in ApJ. 20 pages, 13 figure
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Nocturia as an Unrecognized Symptom of Uncontrolled Hypertension in Black Men Aged 35 to 49 Years.
Background Hypertension is assumed to be asymptomatic. Yet, clinically significant nocturia (≥2 nightly voids) constitutes a putative symptom of uncontrolled hypertension. Black men with hypertension may be prone to nocturia because of blunted nocturnal blood pressure ( BP ) dipping, diuretic drug use for hypertension, and comorbidity that predisposes to nocturia. Here, we test the hypothesis that nocturia is a common and potentially reversible symptom of uncontrolled hypertension in black men. Methods and Results We determined the strength of association between nocturia (≥2 nightly voids) and high BP (≥135/85 mm Hg) by conducting in-person health interviews and measuring BP with an automated monitor in a large community-based sample of black men in their barbershops. Because nocturia is prevalent and steeply age-dependent after age 50 years, we studied men aged 35 to 49 years. Among 1673 black men (mean age, 43±4 years [ SD ]), those with hypertension were 56% more likely than men with normotension to have nocturia after adjustment for diabetes mellitus and sleep apnea (adjusted odds ratio, 1.56; 95% CI , 1.25-1.94 [ P<0.0001]). Nocturia prevalence varied by hypertension status, ranging from 24% in men with normotension to 49% in men whose hypertension was medically treated but uncontrolled. Men with untreated hypertension were 39% more likely than men with normotension to report nocturia ( P=0.02), whereas men whose hypertension was treated and controlled were no more likely than men with normotension to report nocturia ( P=0.69). Conclusions Uncontrolled hypertension was an independent determinant of clinically important nocturia in a large cross-sectional community-based study of non-Hispanic black men aged 35 to 49 years. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unqiue identifier: NCT 02321618
The Roles of the Saccharomyces cerevisiae RecQ Helicase SGS1 in Meiotic Genome Surveillance
leads to an increase in synapsis initiation complexes and axial associations leading to the proposal that it has an early role in unwinding surplus strand invasion events. Physical studies of recombination intermediates implicate it in the dissolution of double Holliday junctions between sister chromatids. chromosomes may sometimes remain entangled at the end of pre-meiotic replication. This, combined with reciprocal crossing over, could lead to physical destruction of the recombined and entangled chromosomes. We hypothesise that Sgs1, acting in concert with the topoisomerase Top2, resolves these structures.This work provides evidence that Sgs1 interacts with various partner proteins to maintain genome stability throughout meiosis
Testicular steroid sulfatase: Substrate specificity and inhibition
Kinetic studies of the cleavage of dehydroepiandrosterone-sulfate (1) and androstenediol-3-sulfate by a particulate enzyme preparation from a rat testicular microsomal fraction gave Km values of 2.04 x 10-6M for DHA-S and 0.935 x 10-6M for androstenediol-3-sulfate with identical Vmax values. Inhibition studies with equimolar concentrations of substrate and inhibitor demonstrated that 5[alpha]-androstane-3[beta],17[beta]-diol was the most potent inhibitor among fifteen C-19 and C-18 unconjugated steroids investigated. Substitution of: 1) a [Delta]4 or [Delta]5 bond or phenolic A ring for a saturated A ring, 2) 17[alpha]-hydroxyl group for a 17[beta]-hydroxyl group, or 3) a 3[alpha]-hydroxyl group for a 3[beta]-hydroxyl group, markedly decreased the inhibitory effect of the steroid. Ki values of 1.7 x 10-6 M, 3.3 x 10-6M and 11.8 x 10-6M were found with 5[alpha]-androstane-3[beta], 17[beta]-diol, 5[alpha]-androstane-3[alpha], 17[beta]-diol and testosterone, respectively. The kinetic data related to inhibition are consistent with partial competitive inhibition.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32862/1/0000239.pd
Measurement of Optical Response of a Detuned Resonant Sideband Extraction Interferometer
We report on the optical response of a suspended-mass detuned resonant
sideband extraction (RSE) interferometer with power recycling. The purpose of
the detuned RSE configuration is to manipulate and optimize the optical
response of the interferometer to differential displacements (induced by
gravitational waves) as a function of frequency, independently of other
parameters of the interferometer. The design of our interferometer results in
an optical gain with two peaks: an RSE optical resonance at around 4 kHz and a
radiation pressure induced optical spring at around 41 Hz. We have developed a
reliable procedure for acquiring lock and establishing the desired optical
configuration. In this configuration, we have measured the optical response to
differential displacement and found good agreement with predictions at both
resonances and all other relevant frequencies. These results build confidence
in both the theory and practical implementation of the more complex optical
configuration being planned for Advanced LIGO.Comment: 6 pages, 4 figures, for submission to Phys Rev Letter
A One-sided, Highly Relativistic Jet from Cygnus X-3
Very Long Baseline Array images of the X-ray binary, Cygnus X-3, were
obtained 2, 4 and 7 days after the peak of a 10 Jy flare on 4 February 1997.
The first two images show a curved one-sided jet, the third a scatter-broadened
disc, presumably at the position of the core. The jet curvature changes from
the first to the second epoch, which strongly suggests a precessing jet. The
ratio of the flux density in the approaching to that in the (undetected)
receding jet is > 330; if this asymmetry is due to Doppler boosting, the
implied jet speed is > 0.81c. Precessing jet model fits, together with the
assumptions that the jet is intrinsically symmetric and was ejected during or
after the major flare, yield the following constraints: the jet inclination to
the line of sight must be < 14 degrees; the cone opening angle must be < 12
degrees; and the precession period must be > 60 days.Comment: 12 pages 7 figures, accepted by Ap
Emotional Distress, Alcohol Use, and Bidirectional Partner Violence Among Lesbian Women
This study examined the relationship between emotional distress (defined as depression, brooding, and negative affect), alcohol outcomes, and bidirectional intimate partner violence among lesbian women. Results lend support to the self-medication hypothesis, which predicts that lesbian women who experience more emotional distress are more likely to drink to cope, and in turn report more alcohol use, problem drinking, and alcohol-related problems. These alcohol outcomes were, in turn, associated with bidirectional partner violence (BPV). These results offer preliminary evidence that, similar to findings for heterosexual women, emotional distress, alcohol use, and particularly, alcohol-related problems are risk factors for BPV among lesbian women
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