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Functional Analysis of the F-box protein Fbxl17
- Author
- Publication venue
- University of Cambridge
- Publication date
- 30/04/2020
- Field of study
Advances in DNA sequencing technology have allowed detailed characterisation of cancer genomes and has highlighted the contribution of somatic structural variations to the mutational landscape of epithelial tumours. However, our understanding of the functional consequences of such genome rearrangements remains rudimentary. By surveying the METABRIC dataset, consisting of segmented array-CGH copy number data, and paired-end whole-genome DNA and RNA sequencing data from primary breast tumours, we found that the F-box protein encoded by FBXL17 is frequently rearranged in breast cancer.
F-box proteins are the substrate-recognition components of Skp1-cullin 1-F-box protein (SCF) E3 ligases. As essential components of the ubiquitin proteasome system (UPS) they are responsible for directing target proteins for ubiquitination. Fbxl17 is a relatively understudied member of the FBXL family of F-box proteins and, in breast cancers, is disrupted in the region of the gene that encodes its substrate-binding leucine rich repeat (LRR) domain. Truncating Fbxl17 LRRs impaired its association with the other SCF holoenzyme subunits Skp1, Cul1 and Rbx1, and decreased its ubiquitination activity. Loss of the LRRs also affected Fbxl17 binding to its targets. Thus, genomic rearrangements in FBXL17 are likely to disrupt SCFFbxl17-regulated networks in cancer cells.
To investigate the functional effect of these rearrangements, we performed a yeast two-hybrid screen to identify Fbxl17-interacting proteins. Among the 37 binding partners Uap1, an enzyme involved in O-GlcNAcylation of proteins was identified most frequently. We demonstrate that Fbxl17 binds to UAP1 directly and inhibits its phosphorylation, which we propose regulates UAP1 activity. Knockdown of Fbxl17 expression elevated O-GlcNAcylation in breast cancer cells, arguing for a functional role for Fbxl17 in this metabolic pathway.
To identify further interacting partners of Fbxl17, we performed a mass spectrometry analysis of purified Fbxl17 SCF E3 ubiquitin ligases. Co-immunoprecipitates were enriched for DNA damage/ DNA repair proteins suggesting a novel role for Fbxl17 in the DNA damage response (DDR). We have demonstrated that Fbxl17 is recruited to DNA damage sites rapidly upon double-stand break (DSB) induction and knockdown of Fbxl17 protein expression sensitises cells to the DNA damaging agent Camptothecin. Furthermore, Fbxl17 can ubiquitinate the tandem BRCT domain of the well-known DDR protein 53BP1, which we propose targets 53BP1 for proteasomal degradation.
In conclusion, we have identified two regulatory networks of Fbxl17 which provide an insight into the role of Fbxl17 in breast cancer pathogenesis. These pathways may be amenable to therapeutic targeting in the future for the treatment of breast cancers rearranged in FBXL17.Breast Cancer Now Funded (2013NovPhD172
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
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- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
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- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
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- Bakthavatsalam Dhanalakshmi
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- Barbash Ian
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- Krishnamoorthy S
- Krishnamurthy Vinodh
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- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial
- Author
- Aakre Elin
- Aasmundstad Tor
- Abbott Tom
- Accurso Giuseppe
- Adams Benita
- Aduse-Poku Maame
- Aherne Caroline
- Ahmad Tahania
- Ahmed Mamoona
- Akeroyd Louise
- Aksnes Einar
- Al-Kadhimi Samuel
- Alampi Daniela
- Alcock Harry
- Alcorn David
- Aldecoa Cesar
- Alexander-Sefre Farhad
- Allan Ashley
- Allana Alisha
- Allen Jonathan
- Allison Joanna
- Alpers Lise-Merete
- Aluri Sireesha
- Amaral Vanessa
- Andersen Nina
- Andrade Edward
- Andreou Prematie
- Anker Robert
- Antonelli Massimo
- Arnold Glenn
- Asis Gretchelle
- Asvall Joerund
- Atterbury Katie
- Awolesi Jennifer
- Babio-Galan Maite
- Babu Sheeba
- Bacciarelli Samantha
- Baillie Kirsty
- Bakke Monica
- Balint Mihaela
- Ballinger Sarah
- Bamford Amy
- Baratozzi Valentina
- Barker Helen
- Barnes Veronica
- Barraclough Lauren
- Barratt Nina
- Barratt-Due Andreas
- Batuwitage Bisanth
- Bean Sarah
- Begum Salma
- Bekele Soliana
- Bell Joanne
- Bell Paula
- Bellini Valentina
- Benavente Melissa
- Benyon Sarah
- Bergin Colin
- Berridge John
- Bertellini Elisabetta
- Bertolotti Valentina
- Betts Rebecca
- Bhagwan Kamal
- Biccard Bruce
- Bignami Elena
- Birch Sian
- Biyase Thuli
- Bjoern\ue5 Gunhild
- Black Ethel
- Blunt Mark
- Boardman Victoria
- Bowman Katie
- Bradley Isabel
- Branney Debbie
- Brattstrom Olof
- Brennan Andrew
- Bridger Hayley
- Brioni Matteo
- Bruni Andrea
- Buckley David
- Bull Christopher
- Buono Antonio
- Burns Karen
- Burt Karen
- Cahill Hazel
- Cain Martyn
- Calcinati Serena
- Calder Verity
- Calli Morena
- Campey Lorraine
- Cardinale Daniela
- Cardoso Sean
- Carling Natalie
- Carnahan Mandy
- Carrera Ronald
- Carrick Mike
- Carvelli Paula
- Cashmore Richard
- Casotto Giulia
- Castagna Luigi
- Chadderton Ian
- Chattersingh Anjalee
- Chau Simon
- Chew Michelle
- Chironga Nyasha
- Chishti Ahmad
- Chiumello Davide
- Chukkambotla Srikanth
- Clark Richard
- Clarke Heidi
- Clayton Matt
- Coetzee Ettienne
- Coetzee Samantha
- Colling Kerry
- Colville Gary
- Conneely Leonora
- Conway Daniel
- Cooper Deborah
- Cooper Lauren
- Cooper Sarah
- Cope Sean
- Corcione Antonio
- Cornell Sarah
- Correia Carmen
- Corso Ruggero
- Cosgrove Joseph
- Cossu Andrea
- Cranshaw Julius
- Cromie Terri-Louise
- Crooks Jennifer
- Cullen Katherine
- Cunningham Mishell
- Curci Maria
- Cutuli Salvatore
- Dahl Anita
- Dalton Carol
- Dalton Claire
- Daly Zoe
- Daniels Allison
- Darai Giulia
- Daum Peter
- Davies Louise
- Day Christopher
- Daysal Gokce
- De Bois Jessica
- De Leonardis Brunella
- De Prada-Mart\uedn Blanca
- Deacon Bethan
- Delgado Carlos
- Della Giovampaola Maria
- Despy Liesl
- Dias Priyanthi
- Dickinson Matthew
- Dickinson Natalie
- Didriksson Helen
- Doble Patricia
- Donatiello Maria
- Doyle Donna
- Doyle Nancileigh
- Drummond Leanne
- Duberley Stephen
- Dunkley Steven
- Dunn Leigh
- Duys Rowan
- Dvorkin Lee
- Eddy Sara
- Edwards Jennifer
- Edwards Mark
- Edwards Zara
- Eeles Alex
- El\uedas Elisa
- Ellinor Katharine
- Ellis Karen
- Ellis Kaytie
- Evans Matthew
- Everett Mary
- Ezihe-Ejiofor Adanma
- Ezihe-Ejiofor Adanma
- Fanigliulo Maria
- Farina Zane
- Farnell-Ward Sarah
- Farrah Helen
- Faulds Matthew
- Feben Alex
- Feldt Linda
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- Figari Elisa
- Filipe Helder
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- Fladby Hege
- Fleming Lorna
- Flint Margot
- Flint Neil
- Flodberg Magnus
- Floris Leda
- Forfori Francesco
- Forshaw Greg
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- Foti Giuseppe
- Fowler Alexander
- Fuller Tracy
- Fulton Laura
- Furlani Stefano
- G\uf3mez-Herreras Jos\ue9
- Gannon Lizzie
- Garcia Amaia
- Gardner Matthew
- Garofalo Eugenio
- Gazzanelli Sergio
- Genetu Roman
- Gerstman Michelle
- Giarratano Antonino
- Gibson Andy
- Gleeson Yvonne
- Glennon Julia
- Goellner Sarah
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- Harvey Eleanor
- Haslop Richard
- Haugaa H\ue5kon
- Hausken John
- Hawes Elizabeth
- Hays Carole
- Hegarty Aoife
- Hegarty Aoife
- Heggelund Bente
- Henderson Steven
- Hepworth David
- Hester Natalie
- Hewson Russell
- Hodgkinson Sheila
- Hodgson Ruth
- Hodkinson Gemma
- Hoel Sindre
- Hoivik Tone
- Holmes Ann
- Hope Susan
- Hornzee Gillian
- Howard Kate
- Howarth Rachel
- Howe Gwenllian
- Howlett Luisa
- Howson Alex
- Hu Ying
- Hudson Karen
- Hughes Christina
- Hui Sarah
- Hutchinson Jenna
- Hutter Joanne
- Ibrahim Mohamed
- Ilyas Carl
- Innes Richard
- Iotti Giorgio
- Ip Peter
- Ivatt Helen
- Jackson Christine
- Jackson Matthew
- James Katherine
- Jammer Ib
- Januszewska Marta
- Jenner Katy
- Jhanji Shaman
- Jigajinni Suyogi
- Jogi Summayyah
- Johnston Paul
- Jones Gerry
- Jones Leanne
- Jorge-Monjas Pablo
- Joseph Gipsy
- Joubert Ivan
- Kahan Brennan
- Kanakaraj Muthuraj
- Kang Soo
- Kasipandian Vidya
- Kasivisvanathan Ramanathan
- Kaur Jasmin
- Kelliher Leigh
- Kelly Sin\ue9ad
- Kent Alissa
- Kibaru Joyce
- Kidel Carlos
- King James
- Kinghorn Stephen
- Kipling Sarah
- Kirk-Bayley Justin
- Kjoesen Gisle
- Klaevahaugen Inge
- Kouridaki Christina
- Krupa Monika
- Kubisz-Pudelko Agnieszka
- Kumar Ram
- Kunst Gudrun
- Kusel Belinda
- Laha Shondipon
- Laklouk Muhammad
- Latif Ahmed
- Lawrence Helen
- Lawton Tom
- Le Poidevin Alison
- Leaver Susannah
- Lee Aaron
- Leitch Andrew
- Lenz Harald
- Leo Alessandra
- Leonard Dee
- Letts Maria
- Lewszuk Adam
- Lynch Ceri
- M\ue5nsson Sandra
- Macedo Joao
- Macfie Caroline
- Mackle Daisy
- Macmillan Josep
- Macrow Christopher
- Maher Karen
- Mahjoob Parisa
- Makowski Arystarch
- Malik Ihtisham
- Manhas Vitul
- Manon Vasi
- Maria Jashmin
- Mariano Victor
- Marsh Veronica
- Martin Tim
- Mason Tracy
- Matthews Laura
- May Shaun
- Mazzola Francesca
- Mbuyisa Mbalenhle
- McArthur Carol
- McAuley Danny
- McCanny Jamie
- Mccullagh Iain
- McGhee Christopher
- McGovern Clare
- McIlveen Erin
- McKay Emma
- McLaughlin Aisling
- McLeavy Laura
- McNeil Margaret
- Mellinghoff Johannes
- Melody Teresa
- Mezzapesa Mario
- Mingo Sara
- Minicozzi Annamaria
- Mistraletti Giovanni
- Molina Esther
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- Monks Kathleen
- Montague Laura
- Montini Luca
- Montoya-Pelaez Felipe
- Morrison Ben
- Moug Susan
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- Mullenheim Jost
- Munro Michael
- Murphy Anthony
- Murphy Zoe
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- Neep Adam
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- Nicholson Alice
- Niebrzegowska Edyta
- Nightingale Jeremy
- Nilsson Malin
- Noble Harriet
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- Northey Martin
- Nutt Chris
- O'Mahony Michelle
- O'Neil Suzanne
- O'Neill Orla
- Ogbeide Vongayi
- Oguntimehin Rachel
- Oliveira Monica
- Oram Shaun
- Organ Angie
- Orrem Hilde
- Pakats Mari-Liis
- Pakou Glykeria
- Palmaverdi Valentina
- Pang Ching Ling
- Pappa Evita
- Park Linda
- Parker Jane
- Parkinson David
- Patel Akshaykumar
- Patel Jaimin
- Patel Panna
- Pates Katherine
- Pathmanathan Byiravey
- Pawley Corinne
- Payne Sara
- Peacock Victoria
- Pearse Rupert
- Peetamsingh Andrew
- Penhaligon Bethany
- Pereira Joel
- Perman Chris
- Peters Steven
- Phillips Alex
- Phoenix Catherine
- Picchioni Raffaella
- Picken Guy
- Piervincenzi Edoardo
- Pinto Manuel
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- Pope Martin
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- Ramkillawan Arisha
- Ramsamy Nirmalabaye
- Ramsaran Richard
- Rangaswamy Girish
- Ranieri Marco
- Rao Baikady Ravishankar
- Reeves Eleanor
- Reite Mads
- Rhodes Andrew
- Richards Nicole
- Rico-Feijoo Jesus
- Righi Claudia
- Roberts Emma
- Roberts Lindsey
- Robinson Frances
- Rocco Monica
- Roche Lisa
- Rodr\uedguez-Jim\ue9nez Rita
- Rodseth Reitze
- Roertveit Linda
- Romero Esther
- Rooms Martin
- Rosbergen Melissa
- Rossi Giuseppe
- Routledge Jacki
- Ryan Christine
- Salberg Armorel
- Salmaso Marco
- Sampson Julia
- Samson Craig
- Sander Caroline
- Santos Filipa
- Savino Martina
- Scott Carmen
- Seidel Philipp
- Sethi Sahiba
- Settesoldi Giacomo
- Shah Nirav
- Shahid Tasnin
- Sheriff Julie
- Shirley Paula
- Shovel Louisa
- Shrestha Tara
- Sibley Pauline
- Sibug Sheena
- Simili Paolo
- Singh Rita
- Sinha Aneeta
- Sira James
- Sivadhas Harry
- Sivarajan Sinduja
- Skene Simon
- Smith Hazel
- Smith Lorna
- Smithson Beth
- Snelson Catherine
- Solala Sivuyisiwe
- Sollesta Kathryn
- Somerville Alastair
- Soria-Garc\ueda Mar\ueda
- Soulsby Graham
- Spadaro Savino
- Spencer William
- Spimpolo Jennifer
- Spruce Elaine
- Stamper Sean
- Stapleton Claire
- Stephens Tim
- Stickley Jo
- Stitt Emily
- Stokes-Denson Jo
- Strathie Grant
- Strudwick Rhea
- Subhedar Emily
- Sutton Peter
- Swain Andrew
- Sweeting Helen
- Syddall Stuart
- Szakmany Tamas
- Tait Moira
- Tait Rebecca
- Tammaro Marcello
- Tan Evalyn
- Tatham Kate
- Taylor Jenna
- Tellan Guglielmo
- Terragni Pierpaolo
- Thomas Marie
- Thomas Peter
- Thomson Milo
- Tibke Clare
- Toennessen Tor Inge
- Tooth David
- Torborg Alexandra
- Tricoli Giuseppe
- Uddin Ruzena
- Uren Sophie
- Uttamlal Trishna
- Veenith Tonny
- Verlander Mark
- Verri Marco
- Vezyrgiannis Marios
- Vigo Ylenia
- Villa Silvia
- Vincent Rachel
- Vohra Ravinder
- Volta Carlo
- von Rahden Richard
- Wakeford Nichola
- Walker Laura
- Walker Sophie
- Walker Susanna
- Walton Jon
- Wan Yize
- Ward Sinead
- Watt Ailsa
- Whalley Jan
- White Thomas
- Whitehouse Arlo
- Whitehouse Tony
- Wilcock Danielle
- Williams Abigail
- Williams Alexandra
- Willis Joan
- Wills Alasdair
- Wilson Matt
- Woods Lindsey
- Wright Stephen
- Yates David
- Yeung Joyce
- Zanoni Andrea
- Zolfaghari Parjam
- Zou Maggie
- Zungu Thembinkosi
- Zwiggelaar Kimberley
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.
Methods: PRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Patients aged 50 years or older who were undergoing elective major open abdominal surgery were randomly assigned (1:1) to receive CPAP within 4 h of the end of surgery or usual postoperative care. Patients were randomly assigned using a computer-generated minimisation algorithm with inbuilt concealment. The primary outcome was a composite of pneumonia, endotracheal re-intubation, or death within 30 days after randomisation, assessed in the intention-to-treat population. Safety was assessed in all patients who received CPAP. The trial is registered with the ISRCTN registry, ISRCTN56012545.
Findings: Between Feb 8, 2016, and Nov 11, 2019, 4806 patients were randomly assigned (2405 to the CPAP group and 2401 to the usual care group), of whom 4793 were included in the primary analysis (2396 in the CPAP group and 2397 in the usual care group). 195 (8\ub71%) of 2396 patients in the CPAP group and 197 (8\ub72%) of 2397 patients in the usual care group met the composite primary outcome (adjusted odds ratio 1\ub701 [95% CI 0\ub781-1\ub724]; p=0\ub795). 200 (8\ub79%) of 2241 patients in the CPAP group had adverse events. The most common adverse events were claustrophobia (78 [3\ub75%] of 2241 patients), oronasal dryness (43 [1\ub79%]), excessive air leak (36 [1\ub76%]), vomiting (26 [1\ub72%]), and pain (24 [1\ub71%]). There were two serious adverse events: one patient had significant hearing loss and one patient had obstruction of their venous catheter caused by a CPAP hood, which resulted in transient haemodynamic instability.
Interpretation: In this large clinical effectiveness trial, CPAP did not reduce the incidence of pneumonia, endotracheal re-intubation, or death after major abdominal surgery. Although CPAP has an important role in the treatment of respiratory failure after surgery, routine use of prophylactic post-operative CPAP is not recommended
\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
- Author
- Abdelnabi Mai
- Abrams Marita K
- Abusheikh Tariq
- Ackerman Cheri M
- Adams Andrew
- Adams Stephanie J
- Agarwalla Anant
- Agbley Kwabea
- Aldrup Megan E
- Alldredge Justin
- Allen Alicia B
- Alvarez Consuelo J
- Alvendia Erica L
- Ament Caitlin
- Anderson John E
- Archambault Alexi
- Armistead Isaac O
- Armstrong Andrew R
- Armstrong William
- Aronhalt Todd
- Ashrawi Yara
- Asinof Sam
- Aso Soham
- Augustine LaJerald
- Baatenberg Lara
- Bahr Thomas J
- Bailey Robert J
- Baker Atlee
- Baker Morgan
- Baldassari Shane M
- Banker Roxanne
- Barberi Chelsea R
- Barnett Jason M
- Bartling Justina R
- Baumgardner Jordan S
- Beck Christopher
- Beck Lauren R
- Beckett Alissa
- Bedard James E J
- Bednarski April E
- Beken Levent H
- Belella Carissa
- Bellush James M
- Benitez Pedro
- Benson Jonathon M
- Bertolet Anne
- Bhalla Satish C
- Bhatiya Chinmoy I
- Blaker Amanda L
- Blunden Christopher E
- Bodenberg Jessica M
- Boham Sampson K
- Bor Matthew J
- Botsford Bobbi
- Boudoures Anna L
- Boudreaux Lauren R
- Bourland Megan
- Brand Jordan P
- Braverman John M
- Brinkley Briana
- Brock Ethan J
- Brooks Dana W
- Broomfield Daniel
- Brouwer Lindsay K
- Brown Adam D
- Brown Ashley S
- Brown Carter
- Brown Marie
- Bryant Ashley
- Bryant Julie
- Burg Martin G
- Burke Christa
- Burkhart Brandon J
- Bushhouse Kelsey T
- Butzler Sarah C
- Caesar Nicole M
- Campana Christopher
- Carney Jordan E
- Caronna Jason
- Carranza David
- Cassidy Daniel W
- Cesko Lejla
- Chamma Norma
- Chandrasekaran Vidya
- Chapman Julia
- Chapman Kayla
- Chase Ian O
- Chau Kim M
- Chavez Miranda
- Chavez Ramiro A
- Chen Maida
- Chiang Scott
- Chlebina Ben
- Choeying Tenzin
- Choi Tiffany Y Y
- Chong Insun
- Christgen Shelbi L
- Christiansen Lena
- Christie Jordan S
- Cifelli Alyssa
- Clark Eric M
- Clark Nicole B
- Clarke-Medley Nicole
- Clary Andrea N
- Cognetti Peter A
- Cohen Heather
- Cole Mara G
- Collins Ashley A
- Conn Michael A
- Conrad Turner
- Conturso Alaina C
- Cooper Kristen M
- Corrielus Maureen
- Cotteleer Rebecca J
- Coulson Kevin
- Cristostomo Michael C
- Cromwell Avery B
- Crowley Matt J
- Crowley Samuel T
- Cruz Samantha
- Cullimore Peterson R
- Custer Ashley F
- Cyranowski Olivia
- Damsteegt Amanda M
- Danner Benjamin L
- Darusz Jess M
- DaSilva Paolo A
- Dauphin Cory M
- Davis Kristen C
- Davis Yelena P
- Davis-Reyes Brionna
- Dawson Seth G
- Debow Calise
- DeFazio Steve
- DeJong Randall J
- Delacruz Noelle
- DeMichele Gabriella A
- Deranek Kelly M
- DeShetler Megan
- Deuschle Frederic J
- DiAngelo Justin R
- Diekema Emily J
- DiLorenzo Lauren A
- Dirkes William
- DiTommaso Tia M
- Dobbe Ali
- Dobbe Ian
- Docking Carter T
- Does Benjamin R
- Dorsett Sasha L
- dos Santos Vieira Carolina Marques
- Dothager Matthew
- Doty Jennifer S
- Dougherty Grace A
- Dow Brian A
- Dowd Rose M
- Downey Kaitlyn A
- Drake Andrew P
- Drewry Melissa
- Drumm Kelly
- Du Chunguang
- Dunbar David A
- Dunham Carrie A
- Earl Erica K
- Echendu Vivienne
- Eckardt Alexandra K
- Eckdahl Todd T
- Edwards Curtis R
- Ehret Sharon C
- Eisen Michelle E M
- Eisler Heather L
- El-Adaimi Jad
- Elder Darcie D
- Elliott GiNell
- Emerson Charlene
- Emerson Julia A
- Emiah Shadie
- English Johnathan D
- Enoch Erica
- Faber Hayley M
- Faber Katherine J
- Fadus Matthew C
- Falk I N
- Fanning John P
- Farek Jesse R
- Farrar Cassandra
- Fearnow Adam
- Feenstra Elizabeth
- Fefelova Nadezhda
- Felzer-Kim Isabella T
- Fese Jessica
- Fick Cameron N
- Fitzgibbons John D
- Flohr Sarah
- Flores Amanda H
- Floyd Trevor G
- Foret Don
- Forsyth Joshua D
- Fosselman Daniel S
- Foust Jonathan D
- Franchi Spencer L
- Freda Philip J
- Freeburg Trip
- French Kristin M
- Friedman Harrison
- Friedrichs Chelsey
- Fusco Zach
- Garibay Edgar
- Garrett Amanda D
- Gaur Shailly
- Geary James F
- Gier Chad
- Gill Ishwar S
- Gilman Hannah
- Glenn Omolara
- Goeller Katie L
- Gomez Carolina
- Gonzales Justin A
- Gooch John
- Goodman Anya L
- Goodwin Zane
- Goscinski Nora C
- Gosser Yuying
- Govind Shubha
- Grantham Alaina J
- Greenwell Alyson
- Grove Ryan A
- Guadron Leslie
- Gutierrez Nestor
- Haberman Adam
- Hales Jasmine
- Hammett Deborah
- Hammond Brandy L
- Hammond Maureen S
- Hanson Cynthia K
- Harding Taylor S
- Hare Amber N
- Hark Amy T
- Harker Katherine S
- Harnoto Raechel S
- Harrington William
- Harris Cameron B
- Hatfield Kristen R
- Hauke Jeanette
- Hauser Charles R
- Havill Jessen T
- Heckman Jonathan M
- Hedeen Heather
- Helmreich Eric
- Hendricksma Jesse
- Hennessy Bryan M
- Henry Tyneshia C P
- Herbstsomer Robert A
- Herrick Douglas A
- Herrold Milton R
- Heslop Michelle
- Hilbrands Julia A
- Hirsch Sarah
- Hockenberger Kelsey
- Holderness Heather L
- Hong Emily L
- Hoogenboom Lindsay
- Hoogewerf Arlene J
- Hoopes Laura L M
- Hoover Betsy
- Hopkins Barbara L
- Howell Emily J
- Howey Nicole A
- Huerta Vilma F
- Ibarra Sharon
- Ibrahem Marwan
- Ighile Osagie
- Intriago Stephanie
- Jacobs Dontae A
- Janssen Bridget M
- Jarrell Jenifer N
- Jelgerhuis Sarah A
- Jelsema Timothy R
- Jewell Elizabeth S
- Jimenez Luis A
- Jipp Jacob
- Johnson Ashlee G
- Johnson Benjamin K
- Johnson Cristen
- Johnson Diana E
- Johnson Jaelyn L
- Johnson Lauriaun
- Johnson Todd D
- Jones Christopher J
- Jones Jennifer K
- Jones Kelly K
- Jones Melissa
- Kabaso Rita
- Kaehler Marian M
- Kaisler Maria
- Kammrath Anna
- Kandahari Adrese
- Kappes Michelle L
- Karaska Elizabeth A
- Katz Brandon M
- Kaur Sukhjit
- Kehoe James L
- Kelley Colleen V
- Kelly Elisabeth A
- Kennedy Andre
- Kennedy William R
- Keny Lauren J
- Kerber John M
- Keysock Nicholas
- Khan Ambreen
- Khayrullina Guzal
- Khoshabian Colin
- Khoury Christopher B
- Kiernan Elizabeth
- Kiley John
- Kim Andrew J
- Kim Anna
- Kim Van
- King Jessica E
- Klett Bethany M
- Knepper John Mark
- Knob Christopher R
- Knouse Kristin A
- Knudsen Nelson H
- Koaches Hannah C
- Koehler Jessica
- Koenig Dana
- Kokan Nighat P
- Kolibas Kimberly S
- Kooienga Ross D
- Koplinsky Chad A
- Kraftmann Karen J
- Kubricky Cassandra
- Kufel Christina N
- Kujawski Alexander J
- Kuleck Gary A
- Kulich Danielle
- Kung Faith
- Kus Jordan E
- Kuschner Cyrus E
- Kusner Matt
- Kwan Wa Shum Yuki
- Ladzekpo Danielle
- LaForge Kristin M
- Lamb Travis
- Lambright Anthony K
- Lammers Jennifer A
- Lane Curtiss E
- Langner Christine
- Lau Dawn
- Lea Charlotte
- Leads Rachel R
- Leatherman Emily C
- LeBlanc Mark T
- Lee Cassidy T
- Lee Paul
- Lemmon Eric
- Leung Wilson
- Lewis Benjamin M
- Li Linghui
- Light Morgan R
- Limle Austin B
- Lin Devry
- Lindbeck Peter
- Lippert Rachel N
- Lopez Lenin
- Lopilato Jane E
- Louie Christopher A
- Lowell Shannon M
- Lu Alvin
- Lucas Gabi
- Luippold Erin K
- Lupey Lena N
- Lydon Anniken M
- Macchi Christopher R
- Machone Joshua F
- Macias Elizabeth
- Macias Jason S
- Maffa Amanda
- Mageeney Catherine M
- Malkowitz Lorraine
- Mammo Danny
- Maniaci Brian J
- Marra Jonathan
- Martinez Megan
- Martiniuc Daniela
- Martinov Tijana
- Mason Portia
- Matthews Jordan E
- May Francis J
- Mayorga Lissett
- Mazur Tammy
- Mazzeo Cheryl
- McCabe Nikie L
- McCartha Shannon R
- McCracken Marly R
- McDonald Mitchell
- McDonough Alexa M
- McFarland Darryl
- McLaughlin Christopher
- Mecoli Jonathan P
- Medina Joseph
- Meghdari Mariam
- Meier Anne C
- Melton Amy D
- Membreno Nelson
- Mendoza Carlos
- Menillo Daniella
- Menyes Erika E
- Mercer Amanda
- Merry Callie R
- Messenger Gregory S
- Messiah Shady
- Messler James
- Meyer Lauren R
- Miller Emily G
- Minnick Phillip J
- Minniti Carl J
- Minton Thomas F
- Misch Jonathan
- Mitchell Ryan D
- Monsma Nicholaus
- Moran Joseph V
- Morgan Abbie
- Morlock Elaine V
- Morris William M
- Morrow Adam T
- Mudumbi Krishna
- Mullen Gregory J
- Muller Sarah E
- Musick Adam E
- Musokotwane Sepo
- Myirski Kevin
- Naik Monal
- Naik Priyanka
- Neufeld Lacey
- Neutzling William
- Newcomb Victoria
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- Newman Alyssa M
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- Ng Simon
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- Nichols Zachary
- Nicolas Daniel S
- Nietmann Jana
- Nikam Vinyak S
- Nollet Eric A
- Nordman Elizabeth C
- Norton Diana
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- Nyabeta Onsarigo Eric
- O\u27Rouke Allison
- Obiorah Ifeanyi
- Ochoa Andrea
- Odisho George
- Ogden Bradley J
- Olson Nicole C
- Ortiz Carlos
- Ostby Kristine
- Osterloh Jeanette M
- Overvoorde Paul J
- Ovu Steven
- Paetkau Don W
- Palozola Katherine C
- Paluskievicz Christina
- Pamnani Brad
- Parrish Susan
- Parry Kesley
- Pasierb Brittany D
- Patao Melissa D
- Patao Shane M
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- Pattison Claire
- Penn Jessica
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- Perella Mallory
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- Peterson Daymon
- Pfeil Jacob J
- Pham Philip
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- Plasman Haley J
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- Polk Jessica W
- Potocny Stephanie J
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- Pozmanter Caitlin
- Prasad Shreya
- Presley Jonathan D
- Price Amber L
- Primus Shekerah
- Puetz William J
- Quach Michael
- Ragland Nicolas
- Raimey England
- Ramic Alen
- Ramirez Roman E, Jr.
- Ramsey Kimberley
- Ramthun Jennifer R
- Randazzo Matt J
- Rankin Helen
- Rathore Sunil
- Ratliff Camille D
- Rauf Sabya A
- Reed Emily
- Reem Rachel M
- Regan Melanie K
- Regisford E Gloria C
- Reilly Mary T
- Rekai Jade Lea
- Rempe Ryan Michael
- Rennhack Jonathan P
- Revie Dennis
- Reynolds Katherine R
- Reynolds Lyndsey A
- Reynolds Thomas J
- Reza Evangelina
- Rhee Dong K
- Rigby Nichole
- Rios Lindsay
- Rivard Allyson B
- Robertson Gregory M
- Robic Srebenka
- Robinett Deirdre
- Robinson Lauren M
- Rodela Laura
- Rodriguez Priscilla
- Rodriguez Vanessa
- Roecklein-Canfield Jennifer A
- Ronk Adam J
- Rooney Meghan B
- Rose Jenny L
- Rose Thomas J
- Rosenwald Anne G
- Rossi Franca G
- Rossi Nadine L
- Rubin Lainey S
- Ruiz Jorge
- Rupley Bryan J
- Sable Joseph E
- Sadovsky Griffin
- Safa Nadia
- Salbert Luke R
- Salgado Michael S
- Saluja Rasleen K
- Salzman Garrett
- Sandusky Michael W
- Sanusi Fareed
- Sassu Eric D
- Saville Kenneth
- Scala Victoria
- Schauder Taylor
- Schepers Allison J
- Schibler Jeanine
- Schiedermeyer Holly
- Schmidt Lasse
- Schmuecker Samantha M
- Schneiter Allison R
- Schottler Jennifer
- Schueler Mary Grace
- Schultz Darrin
- Schulz Robert W
- Schwartz Nicholas U
- Scoma Alexandra H
- Scott Geoff
- Scott Zachary W
- Sessions Bridget J
- Seydoux Marie-Isabelle B
- Shallman Devon
- Shantzer Lindsey
- Sharif Karim A
- Shaw Mary E
- Shelton Micah
- Sherrill Will
- Shevin Yakov
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- Shuford Rebecca
- Silva Valeria
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- Simone Bisogno Laura
- Smith Anna L
- Smith Christopher D
- Smith Jonathan E
- Smith Joshua R
- Smith Karl E
- Smith Mary A
- Smith Melanie A
- Smith Samuel I
- Smith-Gee Maxwell T
- Snavely Michael
- Soliterman Eugenia A
- Song Roy
- Soos Mahdi
- Spaeder Lindsay A
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- Sparks Jeri
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- Tache Melissa A
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- Tenney Jenna C
- Tewilliager Ashley A
- Thistle Katrina
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- Thompson Jeffrey S
- Thomsen Kristen M
- Tilot Amanda K
- Timko Ashley S
- Tirasawasdichai Tiara
- Tomkins Trisha
- Torchon Karvyn
- Townsend Ashley
- Tran Danny L
- Trieu Melissa
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- Tucci Jessica M
- Tumminello Richard A
- Turner Bryce A
- Tynon Marykathryn
- Uitvlugt Chris
- Undem Blair
- Unruh Anna K
- Unzicker Matthew R
- Urick Damian
- Valdez Isabel
- VanderVennen Marielle
- VanDyken Rachel E
- VanEck Eve
- Velasquez Vicente
- Verbofsky Evan M
- Vernon William B
- Vetor Ashley
- Villerot Matthew M
- Vondy Kayla
- Vrable Abby
- Vue Samantha
- Vuong Tam
- Vylonis Megan B
- Waggoner Andrew W
- Walji Tezin A
- Walker Chelsea A
- Wan Tiffany
- Wande Lucia
- Ward Alyssa
- Waters Mary
- Watson David T
- Wawersik Matthew
- Weaver Jennifer A
- Welker Anne A
- Wellinghoff Jules
- Wendland Pete
- Westphal Kyle
- White Jackie X
- Williams Charlotte
- Winkler Stacey
- Winn Wesley W
- Winters Jenifer
- Woehlke Sarah
- Wolski Matthew W
- Wolyniak Michael J
- Wong Jeanette
- Wong Jeremy N
- Woyski Dustin S
- Wurzler Juliana A
- Wylie Anna
- Wysocki Lauren M
- Xiong David
- Xu Amy
- Xu Thomas Q
- Yalamanchili Monica
- Yang Bib
- Yarrington Bryan
- Yemelyanova Anastasia K
- Youngblom Jim
- Yu Nicole S
- Yuan Han
- Zaborowicz Matthew A
- Zarrasola Stephanie
- Zhang Yi
- Zhu Xiao
- Zidan Ameer
- Zumkehr Joannee
- Publication venue
- ScholarWorks@GVSU
- Publication date
- 01/05/2015
- Field of study
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu
Management of coronary disease in patients with advanced kidney disease
- Author
- Abdallah M Abdallah Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew Starovoytov, Andrzej \u141abyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-\uc9ric Gagn\ue9, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Bj\uf6rklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Daugas, Erick Alex\ue1nderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Fl\ue1via Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, Fran\ue7ois Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jes\ufas Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaqu\uedn V Pe\uf1afiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-I\uf1iguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Costa Vieira, Jos\ue9 M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, Jos\ue9 Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel L\uf3pez Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio C\ue9sar Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Shinseki, Matthew Weir, Maura Carina N\ue9dio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdo\u144czyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula Garc\ueda-Gonz\ue1lez, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto Ren\ue9 Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth P\ue9rez-Fern\ue1ndez, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, S\ue9rgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, S\uedlvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, T\ue9odora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fern\ue1ndez-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-R\uedos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek P\ue9pin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
- Alexander K.P.
- Ali Z.A.
- Bangalore S.
- Berger J.S.
- Bockeria O.
- Boden W.E.
- Briguori C.
- Broderick S.
- Chaitman B.R.
- Chertow G.M.
- Fleg J.L.
- Herzog C.A.
- Hochman J.S.
- Huang Z.
- Kaul U.
- Kretov E.I.
- Mark D.B.
- Maron D.J.
- Mathew R.O.
- Mazurek T.
- Newman J.D.
- O'Brien S.M.
- Pracon R.
- Reynolds H.R.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization (if appropriate) added to medical therapy or an initial conservative strategy consisting of medical therapy alone and angiography reserved for those in whom medical therapy had failed. The primary outcome was a composite of death or nonfatal myocardial infarction. A key secondary outcome was a composite of death, nonfatal myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. RESULTS At a median follow-up of 2.2 years, a primary outcome event had occurred in 123 patients in the invasive-strategy group and in 129 patients in the conservative-strategy group (estimated 3-year event rate, 36.4% vs. 36.7%; adjusted hazard ratio, 1.01; 95% confidence interval [CI], 0.79 to 1.29; P=0.95). Results for the key secondary outcome were similar (38.5% vs. 39.7%; hazard ratio, 1.01; 95% CI, 0.79 to 1.29). The invasive strategy was associated with a higher incidence of stroke than the conservative strategy (hazard ratio, 3.76; 95% CI, 1.52 to 9.32; P=0.004) and with a higher incidence of death or initiation of dialysis (hazard ratio, 1.48; 95% CI, 1.04 to 2.11; P=0.03). CONCLUSIONS Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction
Health status after invasive or conservative care in coronary and advanced kidney disease
- Author
- Bangalore S
- Chaitman B.R.
- Chertow G.M.
- Fleg J.L.
- Hochman J.S.
- ISCHEMIA-CKD Research Group: Abdallah M Abdallah Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew Starovoytov, Andrzej \u141abyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-\uc9ric Gagn\ue9, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Bj\uf6rklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Daugas, Erick Alex\ue1nderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Fl\ue1via Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, Fran\ue7ois Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jes\ufas Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaqu\uedn V Pe\uf1afiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-I\uf1iguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Costa Vieira, Jos\ue9 M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, Jos\ue9 Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel L\uf3pez Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio C\ue9sar Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Shinseki, Matthew Weir, Maura Carina N\ue9dio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdo\u144czyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula Garc\ueda-Gonz\ue1lez, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto Ren\ue9 Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth P\ue9rez-Fern\ue1ndez, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, S\ue9rgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, S\uedlvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, T\ue9odora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fern\ue1ndez-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-R\uedos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek P\ue9pin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
- Jones P.G.
- Mark D.B.
- Maron D.J.
- O'Brien S.M.
- Reynolds H.R.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of <30 ml per minute per 1.73 m2 or receipt of dialysis). A secondary objective of the trial was to assess angina-related health status. METHODS We assessed health status with the Seattle Angina Questionnaire (SAQ) before randomization and at 1.5, 3, and 6 months and every 6 months thereafter. The primary outcome of this analysis was the SAQ Summary score (ranging from 0 to 100, with higher scores indicating less frequent angina and better function and quality of life). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate the treatment effect with the invasive strategy. RESULTS Health status was assessed in 705 of 777 participants. Nearly half the participants (49%) had had no angina during the month before randomization. At 3 months, the estimated mean difference between the invasive-strategy group and the conservative-strategy group in the SAQ Summary score was 2.1 points (95% credible interval, 120.4 to 4.6), a result that favored the invasive strategy. The mean difference in score at 3 months was largest among participants with daily or weekly angina at baseline (10.1 points; 95% credible interval, 0.0 to 19.9), smaller among those with monthly angina at baseline (2.2 points; 95% credible interval, 122.0 to 6.2), and nearly absent among those without angina at baseline (0.6 points; 95% credible interval, 121.9 to 3.3). By 6 months, the between-group difference in the overall trial population was attenuated (0.5 points; 95% credible interval, 122.2 to 3.4). CONCLUSIONS Participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease did not have substantial or sustained benefits with regard to angina-related health status with an initially invasive strategy as compared with a conservative strategy
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
- Author
- Aaron James Holland
- Abdullah Jumana T.
- Abrams Jonathan M.
- Abrashoff Riley
- Acevedo Andres B.
- Acha Iker
- Acosta Daniela M. Meza
- Adam Megan M.
- Adams Dante Q.
- Adams Elena R
- Adams Kalvyn N
- Akbar Zainab A.
- Akruwala Ushmi H.
- Al-Ghazwi Adel
- AlAbbas Batool H.
- Alahmed Mohammed S.
- AlAwadhi Areej A.
- Albakr Mohammed A.
- Albalushi Yusef J.
- Albaum Jonathan
- Aldhamen Ahmed
- Ales Nolan
- Alesmail Mohammad
- Alhabeeb Abdulelah
- Alhamli Dania
- AlHarbi Yazeed A.
- Alhuseini Isehaq
- Alkaabi Suhail
- Alkhezzi Tameem
- Alkubaisi Mohamed
- Allanqawi Nasser
- Allsbrook Martin
- Almohsen Yousef A.
- Almquist Justin Thomas
- Alnaji Teeb
- Alnasrallah Yousef A
- Alonzi Nicholas
- Alosaimi Meshal
- Alqabani Emeen
- Alrubaie Mohammad
- Alsinan Reema A.
- Altenbern Ava L.
- Altokhais Abdullah
- Alyami Saleh A.
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- Zenner Thomas
- Zhang Jiaqi
- zhang Jinhua
- Zhao Noah Y.
- Zhao Tiannie
- Zhao Tianwei
- Zhou Chongrui
- Ziebold Josh J
- Ziegler Lucas J.
- Zimmermann Ingrid H
- Zygmunt James C.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 09/05/2023
- Field of study
Flare frequency distributions represent a key approach to addressing one of
the largest problems in solar and stellar physics: determining the mechanism
that counter-intuitively heats coronae to temperatures that are orders of
magnitude hotter than the corresponding photospheres. It is widely accepted
that the magnetic field is responsible for the heating, but there are two
competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To
date, neither can be directly observed. Nanoflares are, by definition,
extremely small, but their aggregate energy release could represent a
substantial heating mechanism, presuming they are sufficiently abundant. One
way to test this presumption is via the flare frequency distribution, which
describes how often flares of various energies occur. If the slope of the power
law fitting the flare frequency distribution is above a critical threshold,
α=2 as established in prior literature, then there should be a
sufficient abundance of nanoflares to explain coronal heating. We performed
>600 case studies of solar flares, made possible by an unprecedented number
of data analysts via three semesters of an undergraduate physics laboratory
course. This allowed us to include two crucial, but nontrivial, analysis
methods: pre-flare baseline subtraction and computation of the flare energy,
which requires determining flare start and stop times. We aggregated the
results of these analyses into a statistical study to determine that α=1.63±0.03. This is below the critical threshold, suggesting that Alfv\'en
waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The
Astrophysical Journal on 2023-05-09, volume 948, page 7