Morphology alterations of skin and subcutaneous fat at NIR laser irradiation combined with delivery of encapsulated indocyanine green

The goal of this study is to quantify the impact of the in vivo photochemical treatment of rats with obesity using indocyanine green (ICG) dissolved in saline or dispersed in an encapsulated form at NIR laser irradiation, which was monitored by tissue sampling and histochemistry. The subcutaneous injection of the ICG solution or ICG encapsulated into polyelectrolyte microcapsules, followed by diode laser irradiation (808 nm, 8    W / cm 2 , 1 min), resulted in substantial differences in lipolysis of subcutaneous fat. Most of the morphology alterations occurred in response to the laser irradiation if a free-ICG solution had been injected. In such conditions, membrane disruption, stretching, and even delamination in some cases were observed for a number of cells. The encapsulated ICG aroused similar morphology changes but with weakly expressed adipocyte destruction under the laser irradiation. The Cochran Q test rendered the difference between the treatment alternatives statistically significant. By this means, laser treatment using the encapsulated form of ICG seems more promising and could be used for safe layerwise laser treatment of obesity and cellulit

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

The research was supported by the Government of the RF (grant 14.Z50.31.0004 to support scientific research projects implemented under the supervision of leading scientists)

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

This work was supported by the Government of the Russian Federation (grant 14.Z50.31.0004 to support scientific research projects implemented under the supervision of leading scientists at Russian Institutions and Russian Institutions of Higher Education)

In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast

crosscheck: This document is CrossCheck deposited related_data: Supplementary Information identifier: Nikita A. Navolokin (ResearcherID) copyright_licence: The PCCP Owner Societies have an exclusive publication licence for this journal history: Received 5 June 2016; Accepted 23 October 2016; Accepted Manuscript published 1 November 2016; Advance Article published 16 November 2016; Version of Record published 30 November 201