Circadian rhythm of urinary pH in man with and without chronic antacid administration

In normal human volunteers, when urinary pH was plotted versus time, the circadian sine-wave type curve was not altered by chronic administration of a commercially available suspension containing a mixture of magnesium and aluminum hydroxides, although the antacid perturbed the entire curve in a more alkaline direction. A single dose of the antacid had little effect on urinary pH. There was a highly significant linear relationship between the change in hydrogen ion concentration during chronic antacid treatment and the initial control urinary hydrogen ion concentration, but there was no significant correlation between change in urinary pH and initial control urinary pH as has been previously reported. The above results were based on the evaluation of the hydrogen ion concentrations of 1562 separate urine samples collected from 24 normal subjects in a three treatment crossover study. It is recommended that: (1) research studies involving drug-drug interactions with antacids be designed to consider the effect of the antacid on the circadian rhythm of urinary pH, and (2) pH values not be averaged as commonly reported in the literature, but rather the pH values be converted to hydrogen ion concentrations before statistical analysis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46636/1/228_2004_Article_BF00561060.pd

Can Creativity Beat Death? A Review and Evidence on the Existential Anxiety Buffering Functions of Creative Achievement

The relationship between creativity and symbolic immortality had been long acknowledged by scholars. In a review of the literature, we found 12 papers that empirically examined the relationship between creativity and mortality awareness using a Terror Management Theory paradigm, overall supporting the notion that creativity plays an important role in the management of existential concerns. Also, a mini meta‐analysis of the impact of death awareness on creativity resulted in a small‐medium weighted mean effect. We examined the existential anxiety buffering functions of creative achievement as assessed by the Creative Achievement Questionnaire in a sample of 108 students. It was found that at high, but not low, levels of creative goals, creative achievement was associated with lower death‐thought accessibility under mortality salience in comparison to controls. To our knowledge, this is the first empirical report of the anxiety buffering functions of creative achievement among people for whom creativity constitutes a central part of their cultural worldview. The current findings support the notion that creative achievement may be an avenue for symbolic immortality, particularly among individuals who value creativity. Implications for understanding death‐related creativity motivations and their impact on individuals and society and for the promotion of creative achievement and creative motivation are discussed