The Inhibitory Effect of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on the Monophenolase and Diphenolase Activities of Mushroom Tyrosinase

In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was extended in the presence of diflunisal. In the presence of indomethacin, the lag time did not change. IC50 values of monophenolase activity were estimated to be 0.112 mM (diflunisal) and 1.78 mM (indomethacin). Kinetic studies of monophenolase activity revealed that both diflunisal and indomethacin were non-competitive inhibitors. For diphenolase activity, IC50 values were estimated to be 0.197 mM (diflunisal) and 0.509 mM (indomethacin). Diflunisal and indomethacin were also found to be non-competitive diphenolase inhibitors

中重奇核の(α, t)反応

京都大学0048新制・課程博士理学博士理博第149号新制||理||102(附属図書館)2273京都大学大学院理学研究科物理学第二専攻(主査)教授 武藤 二郎, 教授 小林 稔, 教授 柳父 琢治学位規則第5条第1項該当Kyoto UniversityDA

Global warming response of snowpack at mountain range in northern Japan estimated using multiple dynamically downscaled data

We estimate the response of snowpack to global warming along with the uncertainty of the snowpack change by using a combination of multiple general-circulation models (GCMs), a single regional atmospheric model, and a one-dimensional multi-layered snowpack model. The target site is Mt. Annupuri in Kutchan, Hokkaido, Japan. The forcing of the snowpack model is taken from dynamically downscaled data from GCMs for the present climate and GCMs in a decade when the global-mean temperature has increased by 2 K from present conditions. The results show that global warming would decrease the monthly-mean snow depth throughout the winter season. Other salient features are the decrease of snow depth by 60 cm with maximum uncertainty of 20 cm at the beginning of the snow ablation period, the occurrence of the snow-depth peak a month earlier, and the dominance of melt forms in an earlier season. The ratio of melt forms for all snowpack layers increases with little uncertainty before the snow ablation period. The ratio of hoar does not change much, even though the air temperature increases. The uncertainty in snowpack evaluation is also discussed. (C) 2017 Elsevier B.V. All rights reserved

Symphony in B minor

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A Two-dimensional Transmission Counter with A Backgammon-Drift Read-Out Technique

A new type of two-dimensional position sensitive gas counter for transmission counter with a backgammon-shaped flat electrode has been developed. The two dimensional position read-out can be achieved with the combination of the backgammon-shaped flat electrode read-out. as horizontal position and the drift time measurement read-out as vertical position. The gas counter is designed as a transmission trajectory counter that can be used to determined angle of incident charged particle in the charged particle detecting system. To check the characteristics of this gas counter, test experiments are performed with a coincidence plastic scintillation counter and p - ray source of 90Sr