<Reports on the Nineteenth Annual Meeting of the Tsukuba English Linguistic Society> A Semantic Approach to Verbal Prefixation : With Special Reference to Prefix Over

In this joint reaearch, we are concerned with the words which have the form of "over- + V". The prefix has two senses: one is spatial/temporal sense, and the other is an "excessive" sense. Specifically, we focus on the later case. The excessive over- is notable for some grammatical phenomena. ..

低分子化合物によるDNA修復因子分解誘導のメカニズム解析

13301甲第4896号博士(薬学)金沢大学博士論文要旨Abstract 要約Outline 掲載予定あ

Subsequent chemotherapy with paclitaxel plus cetuximab-based chemotherapy following immune checkpoint inhibitor in recurrent or metastatic squamous cell carcinoma of the head and neck

BackgroundImmune checkpoint inhibitors (ICIs) are essential in treating recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). However, the overall response rate (ORR) is limited to 10-20%, and subsequent chemotherapy is critical to maximizing the subjects’ prognosis.MethodsWe retrospectively reviewed 59 patients with R/M SCCHN treated with paclitaxel+cetuximab (PE)-based chemotherapy (PCE, paclitaxel+carboplatin+cetuximab; or PTX+Cmab, paclitaxel+cetuximab) following disease progression after either pembrolizumab or nivolumab monotherapy.ResultsOf 59 patients, 15 were treated with pembrolizumab, with an ORR of 13.3%, and the remaining 44 with nivolumab, with an ORR of 11.4%. All patients in the pembrolizumab cohort had platinum-sensitive disease. Following ICI treatment, 19 patients were treated with PCE and the remaining 40 with PTX+Cmab. PE-based chemotherapy induced favorable and prompt tumor shrinkage even in cases where ICI was not effective, with a median change in the summed dimensions of target lesions of -43.4%, resulting in an ORR of 62.7%. Median time to response was 1.8 months. The patients in the pembrolizumab cohort appeared to have a numerically higher response rate than those receiving nivolumab (80.0% vs. 56.8%). For the 59 patients, progression-free survival and overall survival, calculated from the initiation of PE-based chemotherapy, were 4.6 months and 17.1 months, respectively. Grade ≥3 adverse events occurred in 40.7%, and no treatment-related death was observed.ConclusionPE-based chemotherapy following ICI is encouraging for its robust antitumor efficacy in R/M SCCHN

In Orbit Timing Calibration of the Hard X-Ray Detector on Board Suzaku

The hard X-ray detector (HXD) on board the X-ray satellite Suzaku is designed to have a good timing capability with a 61 $\mu$s time resolution. In addition to detailed descriptions of the HXD timing system, results of in-orbit timing calibration and performance of the HXD are summarized. The relative accuracy of time measurements of the HXD event was confirmed to have an accuracy of $1.9\times 10^{-9}$ s s$^{-1}$ per day, and the absolute timing was confirmed to be accurate to 360 $\mu$s or better. The results were achieved mainly through observations of the Crab pulsar, including simultaneous ones with RXTE, INTEGRAL, and Swift.Comment: Accepted for publication on PASJ Vol.60, SP-1, 200