Association between percentage of TCD4 and TCD8 lymphocytes with iron status in female adolescents

Background: Iron deficiency impairs the proliferation and function of T lymphocytes. This study was conducted to assess the relationship between serum iron with percentage of TCD4 and TCD8 lymphocytes in peripheral blood of female high school students in Hamadan. Methods: In this cross-sectional study, 355 female high school students with an age range of 15-18 years were enrolled from January 2016 to March 2017. After approval by the ethics committee of Hamadan University of Medical Sciences, taking written consent of parents, and completion of a questionnaire involving demographic information, serum iron profile, the percentage of TCD4 and TCD8 cells, and TCD4/TCD8 ratio were measured using standard methods. The results were analyzed by SPSS software, version 13. Results: The prevalence of iron deficiency anemia was 16.1% in 355 female high school students of Hamadan. There was no correlation between transferrin saturation with percentage of TCD4 lymphocytes and TCD4/TCD8 ratio in the two groups of students with and without iron deficiency (P>0.05). However, a significant correlation was found between Tfs with percentage of TCD8 lymphocytes in the group of patients with iron deficiency anemia (P<0.05). Conclusion: This study indicated an increased percentage of TCD8 lymphocytes with reduced Tfs in patients with iron deficiency anemia. In addition to reduced Tfs, other factors may be associated with the alterations in percentage of TCD4 and TCD8 lymphocytes and TCD4/TCD8 ratio

Detecting Rates, Trends and Determinants of Cesarean Section Deliveries in Iran Using Generalized Additive Mixed Models

Background: The present study aimed to investigate the trend of cesarean section and its related factors through the recent years. Methods: The study data containing delivery information from Hamadan hospitals and are recorded from 2001 to 2014. The data were analyzed through the generalized additive mixed models using R software (v. 3.2.2). Results: cesarean rate in this study was about 42%. According to the results, the trend of cesarean deliveries almost increased in the recent years. A significant relationship was found between the average age and elective cesarean rate, but, the pregnancy rate didn’t have a significant effect on the elective cesarean rate. Conclusion: Cesarean section rate was more than the allowed limit by world health organization (WHO) that is 15%. Although cesarean delivery is preferred to natural vaginal delivery in the case the mother’s or infant’s life is in danger, it should not replace natural delivery for any reason. Natural vaginal delivery can be promoted by providing the society with the knowledge about the advantages of natural delivery and complications of cesarean section

Predictive Factors of Stages of Change in Hookah Smoking Cessation Among Iranian Adults Based on the Transtheoretical Model

Background: Hookah, as a traditional method of smoking, is widely used in Iran, especially in Bushehr province. It is essential to identify the most important determinants of modifying hookah smoking behavior. This study aimed to investigate the predictors of the stages of change in quitting hookah smoking in 15-60-year-old individuals in Bushehr province, southern Iran, based on the transtheoretical model (TTM).   Methods: This descriptive-analytical study was conducted on 1173 Hookah smokers in Bushehr province. The samples were selected by two-stage random sampling from 10 cities. Data were collected using a valid and reliable questionnaire consisting of 5 sections (demographic characteristics, stages of change, processes of change, decisional balance, and self-efficacy). Data were analyzed by R version.3.3.1 using analysis of variance and ordinal logistic regression at a significant level of 0.05.  Findings: The data revealed 82% of the participants were in the preparatory phase (55.3% in pre-contemplation and 26.7% in contemplation stages). Marital status, family members smoking hookah, cigarette smoking, level of education, number of family members, number of quitting attempts, self-efficacy, self-reevaluation, counter-conditioning, reinforcement management, and stimulus control were predictors of quitting hookah smoking. Conclusion: Given that most study participants were in the inactive stages of quitting hookah smoking, it seems necessary to design and implement behavioral interventions based on the predictive TTM constructs in this population

The protective effect of Zataria multiflora Boiss. hydroalcoholic extract on TNF-α production, oxidative stress, and insulin level in streptozotocin-induced diabetic rats

Objective: Oxidative stress leads to reactive oxygen species (ROS) overproduction, which causes tissue injury in diabetic patients. The aim of this study was to evaluate the effects of Zataria multiflora extract on TNF-α, oxidative stress products, and insulin levels as well as lipid profile in diabetic rats. Materials and Methods: Rats were randomly divided into 6 groups of 10 animals. Diabetes was induced by a single injection of streptozotocin (STZ). Control and diabetic control rats orally received 1 mL/day of normal saline, whereas the other three groups received 250, 500 and 1000 mg/kg/day of Z. multiflora extract, and one non-diabetic group orally received 1000 mg/kg/day Z. multiflora extract, for 28 days. At the end of the treatment course, rats were anesthetized and their serum samples were analyzed for TNF-α, malondialdehyde (MDA), super oxide dismutase (SOD), total antioxidant capacity (TAC), lipid profile, total plasma protein, blood glucose, insulin, and liver enzymes levels. Results: Our results showed that cholesterol, LDL, TG, MDA and TNF-α levels decreased, but HDL, SOD, TAC, and total protein increased significantly in the diabetic group receiving 1000 mg/kg Z. multiflora compared to the diabetic control group (

Cinnamon supplementation improves Blood pressure in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials

Some studies have suggested that consumption of some herbal medicines may improve blood pressure. The present systematic review and meta-analysis was conducted to assess the efficacy of cinnamon supplementation on blood pressure in type 2 diabetic patients. The systematic search was undertaking using several online databases (PubMed, Embase, Scopus and Web of Sciences) to identify randomized controlled trials (RCTs) investigating the effect of cinnamon supplementation on systolic blood pressure (SBP) or diastolic blood pressure (DBP) in type 2 diabetic patients that were published up until 10 December 2019. Potential publication bias was assessed using the Egger regression test. Five full-text articles were included in this meta-analysis. Pooled results of the meta-analysis on 332 participants indicated a significant reduction in SBP and DBP following cinnamon administration. No publication bias was found. The results of the present study suggested that cinnamon might be effective in improving blood pressure in type 2 diabetic patients

Antifungal activities of quince seed mucilage hydrogel decorated with essential oils of Nigella sativa, Citrus sinensis and Cinnamon verum

Background and Objectives: Candidiasis and pityriasis versicolor are opportunistic fungal infections that are caused by Candida spp. and Malassezia spp. yeasts. Conventional drugs like azole and amino derivatives are known to treat fungal skin diseases. However, drawbacks like long-term side effects and drug resistance lead to investigate on antifungal properties of phytochemicals as an alternative to available synthetic drugs. Materials and Methods: The herbal nano hydrogel was successfully synthesized from Quince Seed extract followed by ultrasonic treatment and it has been formulated using a mixture of essential oils. We evaluated the antifungal in vitro assay for a mixture of essential oils in combination with herbal nano hydrogel against Candida albicans and Malasezia furfur strains by micro dilution method. Results: The results indicated that essential oils possess antifungal activity with the MIC value of 12.5 and 6.24 mg/ml against C. albicans and M. furfur, respectively. No fungicidal effect was reported for the herbal hydrogel before nanofabrication while it shown some antifungal activity after ultrasonic treatment for 5 and 10 minutes. As anticipated; the antifungal property of essential oil mixture was appreciably improved when it combined with herbal nano hydrogel where the highest level of inhibition was observed at concentration of 3.125 mg/ml for both strains. The loss in biological activity observed when the ultrasonic treatment on herbal nano hydrogel performed for longer time. Conclusion: The proposed plant-based nano formulation shown promising in vitro antifungal activities against C. albicans and M. furfur strains and its antifungal properties were comparable with commercially available agents like clotrimazole. The new formulation expected to be safe with minimum long-term side effects. Further investigations are underway to confirm the safety and the mechanism of the action of this new herbal formulation

Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data.

peer reviewedAge-related sarcopenia, resulting from a gradual loss in skeletal muscle mass and strength, is pivotal to the increased prevalence of functional limitation among the older adult community. The purpose of this meta-analysis of individual patient data is to investigate the difference in health-related quality of life between sarcopenic individuals and those without the condition using the Sarcopenia Quality of Life (SarQoL) questionnaire. A protocol was published on PROSPERO. Multiple databases and the grey literature were searched until March 2023 for studies reporting quality of life assessed with the SarQoL for patients with and without sarcopenia. Two researchers conducted the systematic review independently. A two-stage meta-analysis was performed. First, crude (mean difference) and adjusted (beta coefficient) effect sizes were calculated within each database; then, a random effect meta-analysis was applied to pool them. Heterogeneity was measured using the Q-test and I2 value. Subgroup analyses were performed to investigate the source of potential heterogeneity. The strength of evidence of this association was assessed using GRADE. From the 413 studies identified, 32 were eventually included, of which 10 were unpublished data studies. Sarcopenic participants displayed significantly reduced health-related quality of life compared with non-sarcopenic individuals (mean difference = -12.32; 95 % CI = [-15.27; -9.37]). The model revealed significant heterogeneity. Subgroup analyses revealed a substantial impact of regions, clinical settings, and diagnostic criteria on the difference in health-related quality of life between sarcopenic and non-sarcopenic individuals. The level of evidence was moderate. This meta-analysis of individual patient data suggested that sarcopenia is associated with lower health-related quality of life measured with SarQoL

Comparing the Effect of a 40-Day Diet of Animal-based and Vegetablebased Protein in Patients with Chronic Kidney Disease under Hemodialysis; a Randomized Clinical Trial

Background: Chronic kidney disease (CKD) is an important health issue that will ultimately require routine dialysis or renal transplantation. Studies on dietary intervention comparing animal and or vegetable protein have not yet validated a suitable protein diet for patients on dialysis. We aimed to compare renal outcomes of patients on dialysis after animal- and vegetable-based protein dietary interventions to be able to designate an appropriate protein diet for patients on dialysis. Methods: In this randomized clinical trial, patients referred to Nemazee Hospital dialysis center, in Shiraz Iran, were randomly divided into two groups of 30 patients: Group A received diet containing 60% animal protein and 40% vegetable protein and group B, 60% vegetable protein and 40% animal protein. Serum level of blood urea nitrogen (BUN), creatinine, serum albumin and total protein were measured. Patients’ weight and blood pressure were also recorded before and after dialysis and compared with values after 40 days of dietary interventions. Results: In group A, creatinine and serum total protein significantly reduced after dietary intervention (P=0.03, and 0.001, respectively). Mediating the effect of dialysis, there was a significant increase in serum total protein (P=0.002), and a significant decrease in serum creatinine (P=0.05) level in group A, while no significant changes were seen in the serum concentration of BUN (P>0.05). Conclusion: 40-day animal- or vegetable-based protein dietary intervention could not significantly change the renal outcome, blood pressure, or body weight of patients with CKD undergoing hemodialysis