Mesoporous molecular sieve MCM-41 catalyzed one-pot synthesis of 3,4-dihydro-2(1H)-pyrimidinones and –thiones under solvent-free conditions

An efficient synthesis of 3,4-dihydro-2(1H)-pyrimidinones and -thiones using MCM-41 as the catalyst from an aldehyde, β-keto ester, and urea or thiourea under solvent-free conditions is described.KEY WORDS: Biginelli reaction, Dihydropyrimidinones, MCM-41, One-pot, Reusable Bull. Chem. Soc. Ethiop. 2011, 25(2), 309-313

EFFICIENT SODIUM SELENATE-CATALYZED SYNTHESIS OF 3,4-DIHYDRO-2(1H)-PYRIMIDINONES AND –THIONES UNDER SOLVENT-FREE CONDITIONS

Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent yields. KEY WORDS: Dihydropyrimidinones, Sodium selenate, Biginelli reaction, Three component reaction Bull. Chem. Soc. Ethiop. 2009, 23(1), 141-144

Compression of three methods of polymerase chain reaction, culture and rapid urease test in diagnosis of Helicobactr pylori in gastric biopsy specimen

Introduction: Helicobactr pylori (H.pylori) infection is related to chronic gastritis, peptic ulcer andduodenal ulcer. Thus, identification and treatment of the infection has a considerable importance. The aimof this study was to compare three methods of polymerase chain reaction (PCR), culture and rapid ureasetest (RUT) in identification of Helicobactr pylori in gastric biopsy specimens.Material and Methods: 263 patients (157 woman and 106 man) who suffering from digestivecomplaints and referred to the endoscopy department of Hajar Hospital in Sharkord (2007, Iran) wereparticipated in the study. Three gastric biopsy samples were collected from each patient. Samples wereexamined by standard RUT and culture methods for diagnosis of H. pylori. PCR was used for diagnosisof ureC gene.Results: Out of 263 patients, 36.49%, 9.50%, 13.30%, 9.48% and 5.50% had criteria gastritis, gastriculcer, duodenal ulcer, esophagitis and gastric cancer, respectively. H.pylori infection was diagnosed in54.37%, 31.94% and 84.79% of the patients by RUT, culture and PCR method, respectively.Conclusion: Findings of this study indicated that PCR has a greater sensitivity rather than rapid ureasetest and culture methods for diagnosis of H.pylori

<b>Efficient sodium selenate-catalyzed synthesis of 3,4-dihydro-2(1<i>H</i>)-pyrimidinones and –thiones under solvent-free conditions</b>

Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1<i>H</i>)-ones or –thiones in excellent yields