Science in Orbit

This talk presents the excitement of doing science in space. It reviews some of the effects of the physical adaptations that the body undergoes to the lower gravity of space. It also discusses the role of the scientist in the space environment. It also discusses the potential uses of space development, particularly with the use of the space station

Where Do Consumers in Nairobi Purchase their Food and Why Does this Matter? The Need for Investment to Improve Kenya's "Traditional" Food Marketing System

Published by Tegemeo Institute for Agricultural Policy and Developmentfood security, food policy, Kenya, food marketing system, Food Consumption/Nutrition/Food Safety, Q18,

Nurses\u27 Alumnae Association Bulletin - Volume 2 Number 1

March of Activities Treasurer\u27s Report It\u27s a Date Loyalty Coming Events Jefferson News In Florida for Winter The A.N.A. Convention Greetings! Keeping Up the Fight Eight Hour Committee Nurses Wanted Class of 1926 Convention Notes Attention Members Pine Street News Class of 1915 Class of 1916 Fifth Anniversary Prize Winners - 1932 Class of 1940 Owners of Scrap Books Sick List - 1939 and 1940 A Program of Nursing Information Please Private Duty Section Excerpts from Alumnae Minutes Staff News Please Remember Personals Engagements Marriages Deaths Hospital News Ballot for Officers Recent Births Lest You Forget! Please Change My Addres

Starting and operating a farmers market : frequently asked questions (2009)

"11/2009.

Image Restoration in the Healthcare Industry: Merck’s Use of Communication Strategies in the Vioxx Case

This study analyzes Merck‟s responses to the crisis involving one if its products, Vioxx, an arthritis and pain-relief medication that was pulled from the market when a study found a higher rate of heart attacks and strokes in patients using the drug than those in a placebo. The study illustrates the use of communication theory and image restoration strategies by utilizing Benoit‟s (1995) Image Restoration Typology. The study uses a critical analysis methodology to examine the communication strategies employed by Merck in order to attempt to restore its image. The authors look at excerpts from media stories, carefully examine the language used by company representatives in response to the crisis, and categorize the corporate communications into various strategies as defined in the crisis communication literature. Corporate responses are critical in determining what amount of damage is done to the firm‟s image during a crisis

Introduction to Local Food Systems

The local production and marketing of food has reached a critical mass in the past few years. Increasingly, people are searching out food that not only is flavorful, healthy and safe but that also supports their local community. Farmers are working hard to meet that demand and are taking advantage of the economic opportunities community-based, or local, food systems provide. Many farmers, particularly mid-sized (often called ?farmers of the middle?) and small-scale producers, find that producing for and selling into a community-based food system is one of the only options left for them, as they lack the scale or financial resources to compete in a larger market. In recognition of the importance of local food systems, the U.S. Department of Agriculture developed the Know Your Farmer, Know Your Food initiative aimed at strengthening the relationships between farmers and consumers throughout the United States. This guide explores the concept of local food systems and provides resources to help farmers, consumers and communities develop food systems that provide for profitable, thriving farms and businesses; steward our natural resources; and strengthen community relationships in rural and urban Missouri.New 4/15/Web.Includes bibliographical reference

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.

BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface. We report the crystal structure of a protein complex containing Vpu and BST2 cytoplasmic domains and the core of the clathrin adaptor protein complex 1 (AP1). This, together with our biochemical and functional validations, reveals how Vpu hijacks the AP1-dependent membrane trafficking pathways to mistraffick BST2. Vpu mimics a canonical acidic dileucine-sorting motif to bind AP1 in the cytosol, while simultaneously interacting with BST2 in the membrane. These interactions enable Vpu to build on an intrinsic interaction between BST2 and AP1, presumably causing the observed retention of BST2 in juxtanuclear endosomes and stimulating its degradation in lysosomes. The ability of Vpu to hijack AP-dependent trafficking pathways suggests a potential common theme for Vpu-mediated downregulation of host proteins.DOI: http://dx.doi.org/10.7554/eLife.02362.001

A Woman for All Seasons: A Biography of Julia Catherine Stimson (1881-1948)

Little is known or written about one of nursing\u27s most enduring and productive leaders, Julia Catherine Stimson. The purpose of this investigation was to examine the life and character of Miss Stimson and to identify the many, diverse contributions which she made to the profession of nursing and to humanity. Additionally through an analysis of her leadership qualities, a profile of an effective nursing leader evolved. The historical method was used in this investigation. Data was collected for the study from the National Archives, the Center of Military History, the New York Hospital/Cornell Medical Center Archives, the New York Historical Society, the Yale University Archives, the Washington University Medical Archives, the Nursing Archives at Boston University, the Brearley School, Vassar College, Mount Holyoke College, the American National Red Cross and the Military Personnel Records Center. Articles in the professional and lay literature also provided rich data. Further biographical information was collected through interviews with individuals who were closely associated with Miss Stimson. Data analysis entailed organizing, integrating, and synthesizing the collected information into a logical sequence which was presented in the form of biography. Findings revealed that Miss Stimson was blessed with a superior ancestry, an ideal childhood, an excellent education, and an inherent drive to succeed. They further disclosed that she excelled in a multitude of roles. Nurse, social worker, soldier, educator, administrator, organizational activist, ethicist, economist, musician, writer, speaker, historian, prophet, humanitarian, patriot, and early feminist, Miss Stimson was a multi-faceted professional whose lengthy career was characterized by strong leadership and significant contributions. The study of Julia Stimson\u27s life from her early years through her Army career, to her tenure as president of the American Nurses\u27 Association has the potential to teach contemporary nurses much about effective leadership. Moreover, the investigation provides a model of a prolific life which modern nurses might emulate. It suggests that the preparation of detailed biographies of other successful nursing leaders might yield substantial benefits for the future

Identification of C. burnetii Type IV Secretion Substrates Required for Intracellular Replication and Coxiella-Containing Vacuole Formation

Coxiella burnetii is a Gram-negative intracellular pathogen that encodes a specialized type IVb secretion system (T4SS) which is essential for intracellular replication, Coxiella-containing vacuole (CCV) formation, modulation of apoptosis, and effector translocation. To identify T4SS candidate substrates, we used an enhanced bioinformatics guided approach. Expression of 234 T4SS candidate substrates as TEM1 β-lactamase fusions identified 53 substrates that were translocated in a Dot/Icm-dependent manner. Large scale screens aimed at identifying localization and function revealed that several of these substrates traffic to distinct subcellular compartments and interfere with crucial host processes. To determine if any of these T4SS substrates are necessary for intracellular replication, we isolated 20 clonal T4SS substrate mutants using the Himar1 transposon and transposase. Of these, 10 mutants exhibited defects in intracellular growth and CCV formation in HeLa and J774A.1 cells, but displayed normal growth in axenic culture. Given their confirmed role in intracellular replication and CCV formation, we named 5 of these substrates CirA-E (Coxiella effector for intracellular replication). To identify the pathways targeted by these crucial substrates, S. cerevisiae strains were co-transformed with pYEp13 yeast genomic library and the T4SS substrates. Using this approach we identified multiple members of the Rho family of GTPases as suppressors of Cbu0041 (CirA) toxicity. Overexpression in mammalian cells resulted in cell rounding, detachment, and reduced stress fibers. Collectively, these results indicate that C. burnetii encodes a large repertoire of T4SS substrates that play integral roles in host cell subversion and CCV formation

Indiana Probation Officer Professional Development Project: Interview Guide

This guide provides information on the design of a structured interview using behavioral based questions aligned to competencies recognized as essential to an Indiana probation officer. The guide discusses the steps involved in an interview process. It also presents a bank of behavior based questions interviewers may wish to use to evaluate candidates for Indiana Probation officer positions. It is organized scientifically to guide the hiring of the most qualified Indiana probation officers in a legally defensible manner. The intention is not to pose every question in this guide to probation officer candidates. Instead, interviewers from each Indiana County may choose the questions from each section that fits their needs.Indiana Office of Court Services (IOCS