Strategies for Successfully Completing Online Professional Development

Recently, increasing demand for teacher professional development and significant advances in information and communication technologies has led to a proliferation of online professional development. In spite of online professional development's popularity and advantages, research indicates that there is a concern of considerably high dropout rates of online learners. Therefore, to reduce the dropout rates of the learners, this paper is designed to help teachers identify professional development opportunities that are tailored to their needs as well as successfully complete these learning experiences. To achieve the purpose of the study, the paper explores the considerations for evaluating the characteristics of online learners and online professional development. Using these evaluations, this paper provides practical strategies for helping elementary and secondary education teachers successfully complete online professional development without dropping out an online course

Production cow-calf responses from perennial forage-based and integrated beef-cropping systems

An experiment was conducted to measure production responses of an alternative cow-calf production system integrated into a cropping system without access to perennial forage compared to a traditional cow-calf system utilizing perennial forage. Multiparous, cross-bred beef cows (n = 160; average age = 6.2 ± 2.8 yr) were utilized in a randomized complete block experimental design and unstructured treatment design. Upon initiation, cows were blocked by age and stratified by source, assigned randomly to one of two production systems, each with four replicates (n = 20 cows/replicate). Once allotted to their treatment groups, cows remained in their experimental units for the duration of the experiment. Treatments were: 1) a traditional system consisting of April to May calving with smooth bromegrass pasture and grazed corn residue as forage resources (TRAD); 2) an alternative system consisting of July to August calving utilizing partial-drylot feeding, summer-planted oats, and corn residue grazing (ALT). There were no differences (P ≥ 0.27) in calving rates (91.8 vs. 86.7 ± 2.92%), pregnancy rates (89.3 vs. 89.9 ± 2.66%), and weaning rates (87.2 vs. 82.3 ± 3.29%) for TRAD vs. ALT, respectively. However, there was an increase (P = 0.04) in the rate of twin offspring in ALT (2.9 vs. 9.4 ± 2.36% for TRAD vs. ALT, respectively). One calf from the set of twins was selected randomly at birth to be removed from the experiment, so the production data are only from single calves. There was no difference (P = 0.47) in calf body weight at birth (40 vs. 39 ± 0.7 kg for TRAD vs. ALT, respectively). At weaning, calves in the ALT system were lighter (P \u3c 0.01) at the same day of age (184 vs. 229 ± 5.5 kg) compared to TRAD calves. Cows from the ALT system had fewer (P \u3c 0.01) kg weaned per cow exposed to bull (150 vs. 199 ± 7.2 kg) compared to TRAD cows. Apart from the twinning rate, no differences in reproductive performance were observed among systems. However, reduced weaning weights and kilogram of weaned calf per cow exposed may negatively impact revenue to the cow-calf enterprise of the ALT system

You Shall Not Pass: How Facial Variability and Feedback Affect the Detection of Low-prevalence Fake IDs

In many real-world settings, individuals rarely present another person’s ID, which increases the likelihood that a screener will fail to detect it. Three experiments examined how within-person variability (i.e., differences between two images of the same person) and feedback may have influenced criterion shifting, thought to be one of the sources of the low-prevalence effect (LPE). Participants made identity judgments of a target face and an ID under either high, medium, or low mismatch prevalence. Feedback appeared after every trial, only error trials, or no trials. Experiment 1 used two controlled images taken on the same day. Experiment 2 used two controlled images taken at least 6 months apart. Experiment 3 used one controlled and one ambient image taken at least 1 year apart. Importantly, receiver operating characteristic curves revealed that feedback and greater within-person variability exacerbated the LPE by affecting both criterion and discriminability. These results carry implications for many real-world settings, such as border crossings and airports, where identity screening plays a major role in securing public safety

Evaluation of growth performance, carcass characteristics, and methane and CO\u3csub\u3e2\u3c/sub\u3e emissions of growing and finishing cattle raised in extensive or partial-intensive cow-calf production systems

An experiment was conducted over 2 yr to measure performance and greenhouse gas (GHG) emissions of weaned calves from two cow-calf production systems. Crossbred steers and heifers (n = 270, initial body weight (BW) = 207 kg, SD = 35) were used in a randomized complete block design, with treatments applied to the cow-calf system. Treatments were: 1) a traditional system consisting of April to June calving with smooth bromegrass pasture and grazed corn residue as forage resources (TRAD); 2) an alternative system consisting of July to September calving utilizing partial-drylot feeding, summer-planted oats, and corn residue grazing (ALT). Calves from both production systems were weaned at the same age and grown (diet NEg = 1.05 Mcal kg–1) for approximately 117 d. The calves then transitioned to a high-grain finishing diet (year 1: NEg = 1.32 Mcal kg–1; year 2: NEg = 1.39 Mcal kg–1) and fed to a targeted 1.52 cm backfat. Growth performance in the grower phase resulted in greater (P \u3c 0.01) average daily gain (1.39 vs. 1.22 ± 0.02 kg), greater gain:feed (P \u3c 0.01; 0.157 vs. 0.137 ± 0.003) for ALT calves compared to TRAD calves, However, a lower initial BW (P \u3c 0.01; 185 vs. 229 ± 4.9 kg) resulted in a lower ending BW (P \u3c 0.01; 347 vs. 371 ± 2.9 kg) for ALT calves compared to TRAD calves in spite of improved growth performance. In the finisher phase, ALT calves gained less (1.52 vs. 1.81 ± 0.218 kg; P = 0.02), were less efficient (0.139 vs. 173 ± 0.0151; P = 0.01) but exhibited similar hot carcass weights (HCW) (388 vs. 381 ± 3.8 kg; P = 0.14) compared to TRAD calves. Each pen of calves was put into a large pen-scale chamber that continuously measured carbon dioxide (CO2 ) and methane (CH4 ) for 5 d during the grower and finisher phases. The average CH4 and CO2 production per unit of feed intake was used to calculate total GHG emissions over the entire grower and finisher phase. Overall, there were no differences (P ≥ 0.17) between treatments for CH4 per day and per kilogram dry matter intake (DMI). However, ALT calves tended to produce less (P ≤ 0.10) CO2 per day and per kilogram DMI than TRAD calves. Overall, methane emissions were greater in ALT calves (110.7 vs. 92.2 ± 8.3 g CH4 kg–1 HCW; P = 0.04) than TRAD calves. The ALT calves required 27 additional days on feed to market, which resulted in more total CH4 per animal across the entire feeding period (P = 0.02) than TRAD calves. Production systems that reduce days to market to achieve similar HCW may reduce GHG emissions

Short-term effects of experimental burning and thinning on soil respiration in an old-growth, mixed-conifer forest

To understand the roles of forest management practices in meeting the goals of forest sustainability and CO2 sequestration, we evaluated the effects of burning and thinning treatments on soil respiration and soil environments in an old-growth, mixed-conifer forest in California’s southern Sierra Nevada. Six experimental treatments with two levels of burning and three levels of thinning were implemented across three dominant patch types: closed canopy (CC), Ceanothus shrub (CECO), and open canopy (OC). We measured soil respiration rate (SRR), soil temperature (T10), moisture (Ms), and litter depth (LD), in the summers of 2000 and 2002. Soil total C and total N were measured in 2002. SRR was significantly different among the three patch types. In 2000, SRR was 0.75, 0.86, and 0.26 g CO2 m-2 hr-1 in CC, CECO, and OC, respectively. In 2002, SRR was 0.79, 0.97, and 0.44 g CO2 m-2 hr-1 in CC, CECO, and OC, respectively. The analysis of variance indicated that burning and thinning significantly affected soil respiration and soil environments. In particular, SRR significantly decreased in burned CECO patches but increased in unburned and thinned CECO. SRR in CC and OC did not significantly change. T10 and Ms increased, whereas LD and soil C decreased in treated patches. We also developed pre- and posttreatment exponential models to predict SRR using soil environmental variables. The effects of burning and thinning on soil CO2 efflux and soil environments imply that forest carbon pools would be reorganized with widespread application of these forest management practices.Keywords: Thinning, Soil moisture, Soil temperature, Prescribed burning, Mixed conifer, Soil respiratio

Variations in Implementation of Specifications Grading in STEM Courses

Specifications grading is an assessment strategy based on mastery learning, clear learning objectives, and frequent evaluations and feedback. Twelve instructors at a southeastern four-year public college implemented the specifications grading method across eight discrete courses in four STEM areas. In this modified assessment strategy, the students controlled their grades through multiple attempts, with limitations, on assessments of course objectives. The instructors designed and executed specifications grading in unique ways that aligned with their content areas, teaching beliefs, and individual teaching styles. Preliminary observations suggest that, regardless of subject area, specifications grading can be used as an alternative to traditional assessment methodologies in STEM courses, regardless of the content area. In general, three major variations of implementation arose from this initial trial. Major differences and commonalities among these types are discussed as they relate to the course subject area in which they are used. The results of this work add a unique set of assessment practices to the current body of knowledge in that other practitioners may gain insight on variations of the specifications grading method that may be practical and applicable in their own classrooms

Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors.

Background IMGN901 is a CD56-targeting antibody-drug conjugate designed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1 study investigated the safety, tolerability, pharmacokinetics, and preliminary activity of IMGN901 in patients with CD56-expressing solid tumors. Methods Patients were enrolled in cohorts of escalating IMGN901 doses, administered intravenously, on 3 consecutive days every 21 days. A dose-expansion phase accrued patients with small cell lung cancer (SCLC), Merkel cell carcinoma (MCC), or ovarian cancer. Results Fifty-two patients were treated at doses escalating from 4 to 94 mg/m(2)/day. The maximum tolerated dose (MTD) was determined to be 75 mg/m(2). Dose-limiting toxicities included fatigue, neuropathy, headache or meningitis-like symptoms, chest pain, dyspnea, and myalgias. In the dose-expansion phase (n = 45), seven patients received 75 mg/m(2) and 38 received 60 mg/m(2) for up to 21 cycles. The recommended phase 2 dose (RP2D) was established at 60 mg/m(2) during dose expansion. Overall, treatment-emergent adverse events (TEAEs) were experienced by 96.9 % of all patients, the majority of which were Grade 1 or 2. The most commonly reported Grade 3 or 4 TEAEs were hyponatremia and dyspnea (each 8.2 %). Responses included 1 complete response (CR), 1 clinical CR, and 1 unconfirmed partial response (PR) in MCC; and 1 unconfirmed PR in SCLC. Stable disease was seen for 25 % of all evaluable patients who received doses ≥60 mg/m(2). Conclusions The RP2D for IMGN901 of 60 mg/m(2) administered for 3 consecutive days every 3 weeks was associated with an acceptable tolerability profile. Objective responses were observed in patients with advanced CD56+ cancers

New highlights on stroma–epithelial interactions in breast cancer

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches

Comparison of Skeletal Effects of Ovariectomy Versus Chemically Induced Ovarian Failure in Mice

Bone loss associated with menopause leads to an increase in skeletal fragility and fracture risk. Relevant animal models can be useful for evaluating the impact of ovarian failure on bone loss. A chemically induced model of menopause in which mice gradually undergo ovarian failure yet retain residual ovarian tissue has been developed using the chemical 4-vinylcyclohexene diepoxide (VCD). This study was designed to compare skeletal effects of VCD-induced ovarian failure to those associated with ovariectomy (OVX). Young (28 day) C57Bl/6Hsd female mice were dosed daily with vehicle or VCD (160 mg/kg/d, IP) for 15 days (n = 6–7/group) and monitored by vaginal cytology for ovarian failure. At the mean age of VCD-induced ovarian failure (∼6 wk after onset of dosing), a different group of mice was ovariectomized (OVX, n = 8). Spine BMD (SpBMD) was measured by DXA for 3 mo after ovarian failure and OVX. Mice were killed ∼5 mo after ovarian failure or OVX, and bone architecture was evaluated by μCT ex vivo. In OVX mice, SpBMD was lower than controls 1 mo after OVX, whereas in VCD-treated mice, SpBMD was not lower than controls until 2.9 mo after ovarian failure (p < 0.05). Both VCD-induced ovarian failure and OVX led to pronounced deterioration of trabecular bone architecture, with slightly greater effects in OVX mice. At the femoral diaphysis, cortical bone area and thickness did not differ between VCD mice and controls but were decreased in OVX compared with both groups (p < 0.05). Circulating androstenedione levels were preserved in VCD-treated mice but reduced in OVX mice relative to controls (p < 0.001). These findings support that (1) VCD-induced ovarian failure leads to trabecular bone deterioration, (2) bone loss is attenuated by residual ovarian tissue, particularly in diaphyseal cortical bone, and (3) the VCD mouse model can be a relevant model for natural menopause in the study of associated bone disorders