Masters of Paradise: Organized Crime and the Internal Revenue Service in the Bahamas

Review of the book by Alan A. Bloc

Thomas Hobbes and Political Theory

This volume explores, from a variety of perspectives, the political theory of the man who is arguably the greatest English political thinker. It is the first substantial collection of new, critical essays on Thomas Hobbes by leading scholars in over a decade. Hobbes’s writings stirred debate in his own lifetime, for two centuries thereafter, and continue to do so in ours. They emerged in a period of intense political turmoil—a time of civil war and regicide, of puritanical rule and royal restoration. “They were motivated,” Dietz argues, “by concrete political problems and a practical concern, namely, to secure political order, absolute sovereignty, and civil peace.” The contributors emphasize and answer a series of expressly political questions that, to date, have not been fully addressed in the Hobbes literature. They contend that Hobbes’s writings are not mere static artifacts of a particular historical milieu, but rather rich sources of a variety of interpretations and criticisms that spur discussion and debate in their turn. Description Mary G. Dietz is John Evans Professor of Political Science at Northwestern University. She is the author of Turning Operations: Feminism, Arendt, and Politics and Between the Human and the Divine: The Political Thought of Simone Weil. With a New Preface by the Author. This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.https://digitalcommons.pittstate.edu/kansas_open_books/1016/thumbnail.jp

A history of the theatre in Louisville.

A child is considered by some psychologists to pass through on its way to manhood the stages through which the race has passed on its way to civilization. If this is true of a single man, might it not equally be true of a community of men? Have not most settlements, in greater or a less degree, passed through the stages of development common to the growth of all cities until they have reached the standards of their day? A company of civilized men and women going forth to make a settlement in a new place, upon their arrival at their destination, are first of all concerned with the bare necessities of living. They must have food, clothing, and shelter. When these are found and in a measure made certain of, the community is ready for something more. Men are so formed by nature that besides bodily comfort they need mental recreation. In the rather primitive community, which lacks the advantages of books and culture, men are prone to come together and provide amusement for each other. When their own amusement no longer satisfies, they make use of strangers who come into their little world and try to persuade other strangers to come to them. Gradually, then, when more and more outsiders begin to come, the people feel a responsibility for their settlement, and a structure will be built to house these travelers who bring thought and pleasure from the world outside. Such might be considered the development of many cities in America, especially those cities west of the Alleghany mountains. It was life for which they were eager life from which in a measure these people who came west had voluntarily shut themselves away – yet for which they longer. And in that longing they were no different from every other man who goes to the theatre. The average spectator – disappointed, for the moment, by his individual experience of living at large – attends the theatre in the hope of quickening his consciousness of life. He wants the play to happen not so much upon the stage as in himself. He goes to the theatre – quite literally – to enjoy himself; that is to say, - his own contributive response of emotion and of thought. The play must happen to him; or else by his judgment the play must be dismissed as a failure. – Life is what the public seeks in going to the theatre; and the appearance, or else the illusion, of life is what it welcomes and rewards in those who exert themselves behind the footlights. (Clayton Hamilton – Seen on the Stage – Pages 7 and 9.

Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.

BackgroundThe long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. The influence of environmental chemicals on breast cancer risk may be greater during several windows of susceptibility (WOS) in a woman's life, including prenatal development, puberty, pregnancy, and the menopausal transition. These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. Breast cancer research focused on these breast cancer WOS will accelerate understanding of disease etiology and prevention.Main textDespite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland's structure and function, most human studies of environmental chemicals are not focused on specific WOS. This article reviews studies conducted over the past few decades that have specifically addressed the effect of environmental chemicals and metals on breast cancer risk during at least one of these WOS. In addition to summarizing the broader evidence-base specific to WOS, we include discussion of the NIH-funded Breast Cancer and the Environment Research Program (BCERP) which included population-based and basic science research focused on specific WOS to evaluate associations between breast cancer risk and particular classes of endocrine-disrupting chemicals-including polycyclic aromatic hydrocarbons, perfluorinated compounds, polybrominated diphenyl ethers, and phenols-and metals. We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers.ConclusionsAn integrative model of breast cancer research is needed to determine the impact and mechanisms of action of endocrine disruptors at different WOS. By focusing on environmental chemical exposure during specific WOS, scientists and their community partners may identify when prevention efforts are likely to be most effective

International Media Assistance

As an introduction to this special issue this article deals firstly with defining and clarifying terms and concepts which are used in the context of international media assistance. Secondly, the themes of the different articles in this collection are enumerated: these are broadly the how to of media assistance, evaluation and the ongoing debate about proving impact of media assistance project; negotiating the tensions between the state and the media and finally, the fundamental question of why and to what purpose is assistance to the media sector given in the first place. The first two of these themes are developed in slightly more depth. The piece is rounded off with some further reflections on the history both of the idea of media assistance and of the way it has been practiced in recent decades. It finally looks at the ways research in this field may develop in the future

Scientific mindfulness: a foundation for future themes in international business

We conceptualize new ways to qualify what themes should dominate the future IB research agenda by examining three questions: Whom should we ask? What should we ask and which selection criteria should we apply? What are the contextual forces? We propose scientific mindfulness as the way forward for generating themes in IB research

Metastatic disease to the breast: the Washington University experience

<p>Abstract</p> <p>Background</p> <p>Metastases to the breast occur rarely, but may be increasing in incidence as patients live longer with malignant diseases. The aim of this study is to characterize metastatic disease to the breast and to describe the management and prognosis of patients who present with this diagnosis.</p> <p>Methods</p> <p>A retrospective review of our institution's pathology and breast cancer databases was performed in order to identify patients with breast malignancies that were not of primary breast origin. Chart review provided additional information about the patients' primary malignancies and course of illness.</p> <p>Results</p> <p>Between 1991 and 2006, eighteen patients with metastatic disease to the breast of non-hematologic origin were identified and all had charts available for review. Among the 18 patients with disease metastatic to the breast, tissues of origin included 3 ovarian, 6 melanoma, 3 medullary thyroid, 3 pulmonary neuroendocrine, 1 pulmonary small cell, 1 oral squamous cell, and 1 renal cell. Overall mean survival after diagnosis of metastatic disease to the breast was 22.4 months. Treatment of metastases varied and included combinations of observation, surgery, radiation, and chemotherapy. Five patients (27.8%) required a change in management of their breast disease for local control.</p> <p>Conclusion</p> <p>Due to the variable course of patients with metastatic disease, a multi-disciplinary approach is necessary for each patient with disease metastatic to the breast to determine optimal treatment. Based on our review, many patients survive for long periods of time and local treatment of metastases to the breast may be beneficial in these patients to prevent local complications.</p

Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139073/1/jah31693.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139073/2/jah31693_am.pd

Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of in vitro amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma

BACKGROUND: Dendritic cells (DCs) have been used as vaccines in clinical trials of immunotherapy of cancer and other diseases. Nonetheless, progress towards the use of DCs in the clinic has been slow due in part to the absence of standard methods for DC preparation and exposure to disease-associated antigens. Because different ex vivo exposure methods can affect DC phenotype and function differently, we studied whether electroporation-mediated transfection (electrotransfection) of myeloid DCs with in vitro expanded RNA isolated from tumor tissue might be feasible as a standard physical method in the preparation of clinical-grade DC vaccines. METHODS: We prepared immature DCs (IDCs) from CD14(+ )cells isolated from leukapheresis products and extracted total RNA from freshly resected melanoma tissue. We reversely transcribed the RNA while attaching a T7 promoter to the products that we subsequently amplified by PCR. We transcribed the amplified cDNA in vitro and introduced the expanded RNA into IDCs by electroporation followed by DC maturation and cryopreservation. Isolated and expanded mRNA was analyzed for the presence of melanoma-associated tumor antigens gp100, tyrosinase or MART1. To test product safety, we injected five million DCs subcutaneously at three-week intervals for up to four injections into six patients suffering from stage IV malignant melanoma. RESULTS: Three preparations contained all three transcripts, one isolate contained tyrosinase and gp100 and one contained none. Electrotransfection of DCs did not affect viability and phenotype of fresh mature DCs. However, post-thaw viability was lower (69 ± 12 percent) in comparison to non-electroporated cells (82 ± 12 percent; p = 0.001). No patient exhibited grade 3 or 4 toxicity upon DC injections. CONCLUSION: Standardized preparation of viable clinical-grade DCs transfected with tumor-derived and in vitro amplified mRNA is feasible and their administration is safe