Awareness on Digital Drugs Abuse and its Applied Prevention among Healthcare Practitioners in KSA

Digital drugs abuse, also known as I-dosing, has recently emerged as a danger to Middle Eastern teen­agers through different media channels. This study aimed to investigate the level of knowledge of digital drug abuse among health practioners in KSA, explore their attitude towards it and describe the possible pre­ventive policies if any, and their experience of any medicolegal implemented awareness strategies to combat this phenomenon.  A cross-sectional survey was used to gather data. An open-ended questionnaire with two parts contain­ing open-ended questions was developed, validated, pretested, and randomly distributed to 200 voluntary participating health care practitioners of both sexes (n = 200) attending a continuous medical education seminar in May 2015 held in Madinah. Ethical approval and an informed written consent was obtained. Participants were males (65%) and females (35%) with different professional degrees. The knowledge of I-dosing of digital drugs was 30%. The source of this knowledge was through media (96%) and through receiving inquiries concerning this topic (71.9%). Only 14.7% of participants knew the mechanism of action of digital drugs. However, 65% of the participants thought digital drugs are real threats. From the participants, 16.9% were approached by an awareness program concerning this issue. This study concluded the urgent need for an awareness program directed at medical practitioners and communities in KSA.   Keywords: Forensic Science, Digital Drug, I-Dosing, Teenage, Abuse, Prevention, Healthcare Practitioners

Awareness on Digital Drugs Abuse and its Applied Prevention Among Healthcare Practitioners in KSA

Digital drugs abuse, also known as I-dosing, has recently emerged as a danger to Middle Eastern teen­agers through different media channels. This study aimed to investigate the level of knowledge of digital drug abuse among health practioners in KSA, explore their attitude towards it and describe the possible pre­ventive policies if any, and their experience of any medicolegal implemented awareness strategies to combat this phenomenon.  A cross-sectional survey was used to gather data. An open-ended questionnaire with two parts contain­ing open-ended questions was developed, validated, pretested, and randomly distributed to 200 voluntary participating health care practitioners of both sexes (n = 200) attending a continuous medical education seminar in May 2015 held in Madinah. Ethical approval and an informed written consent was obtained. Participants were males (65%) and females (35%) with different professional degrees. The knowledge of I-dosing of digital drugs was 30%. The source of this knowledge was through media (96%) and through receiving inquiries concerning this topic (71.9%). Only 14.7% of participants knew the mechanism of action of digital drugs. However, 65% of the participants thought digital drugs are real threats. From the participants, 16.9% were approached by an awareness program concerning this issue. This study concluded the urgent need for an awareness program directed at medical practitioners and communities in KSA.   Keywords: Forensic Science, Digital Drug, I-Dosing, Teenage, Abuse, Prevention, Healthcare Practitioners

Increased tissue leptin hormone level and mast cell count in skin tags: A possible role of adipoimmune in the growth of benign skin growths

Background: Skin tags (ST) are common tumors. They mainly consist of loose fibrous tissue and occur on the neck and major flexures as small, soft, pedunculated protrusions. Decrease in endocrine, hormone level and other factors are thought to play a role in the evolution of ST. Leptin is an adipocyte-derived hormone that acts as a major regulatory hormone for food intake and energy homeostasis. Leptin deficiency or resistance can result in profound obesity and diabetes in humans. A role of mast cell in the pathogenesis of ST is well recognized. Aims: To investigate the role of leptin in the pathogenesis of ST and to clarify whether there is a correlation between mast cell count and leptin level in ST. Methods: Forty-five skin biopsies were taken from 15 patients with ST. From each patient, a biopsy of a large ST (length >4 mm), a small ST (length <2 mm) and a normal skin biopsy (as a control) were taken. The samples were processed for leptin level. Skin biopsies were stained with hematoxylin and eosin and toluidine blue-uranyl nitrate metachromatic method for mast cell count was used. Results: There was a significant increased level of leptin in the ST compared to the normal skin. It was highly significant in small ST than in big ST (P = 0.0001) and it was highly significant in small and big ST compared to controls, P = 0.0001 and P = 0.001, respectively. There was a significant increase in mast cell count in the ST, which did not correlate with the increased levels of leptin. Conclusion: This is the first report to demonstrate that tissue leptin may play a role in the pathogenesis of ST. The significant increase in the levels of leptin and mast cell count in ST may indicate a possible role of adipoimmune in the benign skin growths

PON1 Inter-individual Enzymatic activity variation as a predictor of OPC toxicity in agricultural workers presented to PCCASU, Egypt

Organophosphate compounds result in numerous toxicities because of their widespread usage and easy accessibility especially in the developing world’s agricultural communities. PON1 activity towards OPCs shows inter individual variations. Isoforms of the enzyme differing in their PON1 activity result from amino acid substitutions at positions 192 which is glutamine (Q) to arginine (R) and at 55 which is leucine (L) to methionine (M) thus rendering the identifi cation of individuals’ PON1 all enzymes of value in treatment of patients suffering from OP intoxication The aim of this work is to study the infl uence of genetic variation of PON1 gene on paraoxonase enzyme activity in cases of acute organ phosphorus compound poisoning. These compounds exert their toxicity primarily through inhibiting acetyl cholinesterase (AChE) enzyme. This study was carried out at the Poison Control Center (PCC) of Ain Shams University Hospitals, Cairo, Egypt. Paraoxonase enzyme activity: It was determined according to the method of Furlong et al. (1988). Paraoxonase genotyping: Genomic DNA was isolated from peripheral white blood cells by an automated isolation method using the MagNA Pure LC Total Nucleic Acid Isolation Kit. From this study it is obvious that PON1 coding could be a predictor of individual sensitivity to OPC especially among risk groups as agricultural workers and workers in OP factories.</p

Silver Nanoparticle Synthesis by <i>Rumex vesicarius</i> Extract and Its Applicability against Foodborne Pathogens

The consumption of foods polluted with different foodborne pathogens such as fungus, viruses, and bacteria is considered a serious cause of foodborne disease in both humans and animals. Multidrug-resistant foodborne pathogens (MRFP) cause morbidity, death, and substantial economic loss, as well as prolonged hospitalization. This study reports on the use of aqueous Rumex leaf extract (ARLE) in the synthesis of silver nanoparticles (ARLE-AgNPs) with versatile biological activities. The synthesized ARLE-AgNPs had spherical shapes with smooth surfaces and an average hydrodynamic size of 27 nm. ARLE-AgNPs inhibited the growth of Escherichia coli ATCC25721, Pseudomonas aeruginosa ATCC27843, Streptococcus gordonii ATCC49716, Enterococcus faecalis ATCC700813, and Staphylococcus aureus ATCC4342. The ARLE-AgNPs were more active against Escherichia coli ATCC25721 than other harmful bacterial strains (26 ± 3 mm). The zone of inhibition for antibacterial activity ranged between 18 ± 3 mm and 26 ± 3 mm in diameter. The nanoparticles’ MIC values varied from 5.19 µg/mL to 61 µg/mL, while their MBC values ranged from 46 µg/mL to 119 µg/mL. The nanoparticles that were created had antioxidant potential. The cytotoxic activity was tested using normal fibroblast cell lines (L-929), and the enhanced IC50 value (764.3 ± 3.9 g/mL) demonstrated good biological compatibility. These nanoparticles could be evolved into new antibacterial compounds for MRFP prevention

Global Incidence and Risk Factors Associated With Postoperative Urinary Retention Following Elective Inguinal Hernia Repair

Importance Postoperative urinary retention (POUR) is a well-recognized complication of inguinal hernia repair (IHR). A variable incidence of POUR has previously been reported in this context, and contradictory evidence surrounds potential risk factors.Objective To ascertain the incidence of, explore risk factors for, and determine the health service outcomes of POUR following elective IHR.Design, Setting, and Participants The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) study, an international, prospective cohort study, recruited participants between March 1 and October 31, 2021. This study was conducted across 209 centers in 32 countries in a consecutive sample of adult patients undergoing elective IHR.Exposure Open or minimally invasive IHR by any surgical technique, under local, neuraxial regional, or general anesthesia.Main Outcomes and Measures The primary outcome was the incidence of POUR following elective IHR. Secondary outcomes were perioperative risk factors, management, clinical consequences, and health service outcomes of POUR. A preoperative International Prostate Symptom Score was measured in male patients.Results In total, 4151 patients (3882 male and 269 female; median [IQR] age, 56 [43-68] years) were studied. Inguinal hernia repair was commenced via an open surgical approach in 82.2% of patients (n = 3414) and minimally invasive surgery in 17.8% (n = 737). The primary form of anesthesia was general in 40.9% of patients (n = 1696), neuraxial regional in 45.8% (n = 1902), and local in 10.7% (n = 446). Postoperative urinary retention occurred in 5.8% of male patients (n = 224), 2.97% of female patients (n = 8), and 9.5% (119 of 1252) of male patients aged 65 years or older. Risk factors for POUR after adjusted analyses included increasing age, anticholinergic medication, history of urinary retention, constipation, out-of-hours surgery, involvement of urinary bladder within the hernia, temporary intraoperative urethral catheterization, and increasing operative duration. Postoperative urinary retention was the primary reason for 27.8% of unplanned day-case surgery admissions (n = 74) and 51.8% of 30-day readmissions (n = 72).Conclusions The findings of this cohort study suggest that 1 in 17 male patients, 1 in 11 male patients aged 65 years or older, and 1 in 34 female patients may develop POUR following IHR. These findings could inform preoperative patient counseling. In addition, awareness of modifiable risk factors may help to identify patients at increased risk of POUR who may benefit from perioperative risk mitigation strategies

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population