Region-of-interest based rate control scheme for high efficiency video coding

International audienceIn this paper, we propose a new rate control scheme designed for the newest high efficiency video coding (HEVC) standard, and aimed at enhancing the quality of regions of interest (ROI). Our approach allocates a higher bit rate to the region of interest while keeping the global bit rate close to the assigned target value. This algorithm is developed for a videoconferencing system, where the ROIs (typically, faces) are automatically detected and each coding unit is classified in a region of the interest map. This map is given as input to the rate control algorithm and the bit allocation is made accordingly. Experimental results show that the proposed scheme achieves accurate target bit rates and provides an improvement in the region of interest quality, both in objective metrics and based on subjective quality evaluation

ROI-BASED RATE CONTROL USING TILES FOR AN HEVC ENCODED VIDEO STREAM OVER A LOSSY NETWORK

International audienceThe growth in the use of high definition (HD) and above video resolutions streams has outstripped the rate at which network infrastructure has been deployed. Video streaming applications require appropriate rate control techniques that make use of the specific characteristics of the video content, such as the regions of interest (ROI). With the introduction of high efficiency video coding (HEVC) streams, we consider new coding features to make a novel ROI-based rate control (RC) algorithm. The proposed approach introduces tiling in a ROI-based rate control scheme. It aims at enhancing the quality of important regions (i.e. faces for a videoconferencing system) considering independently coded regions lying within an ROI and helps evaluating the ROI quality under poor channel conditions. Our work consists of two major steps. First, we designed a RC algorithm based on an independent processing of tiles of different regions. Second, we investigate the effect of ROI-and tile-based rate control algorithm on the decoded quality of the stream transmitted over a lossy channel

Spatial and seasonal variation in reproductive indices of the clupeids Limnothrissa miodon and Stolothrissa tanganicae in the Congolese waters of northern Lake Tanganyika

publishedVersio

DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity

International audienceDedicator of cytokinesis (DOCK) proteins play a central role in actin cytoskeleton regulation. This is highlighted by the DOCK2 and DOCK8 deficiencies leading to actinopathies and immune deficiencies. DOCK8 and DOCK11 activate CDC42, a RHO-GTPase involved in actin cytoskeleton dynamics, among many cellular functions. The role of DOCK11 in human immune disease has been long suspected but has never been described so far. We studied eight male patients, from seven unrelated families, with hemizygous DOCK11 missense variants leading to reduced DOCK11 expression. The patients were presenting with early-onset autoimmunity, including cytopenia, systemic lupus erythematosus, skin, and digestive manifestations. Patients’ platelets exhibited abnormal ultrastructural morphology and spreading as well as impaired CDC42 activity. In vitro activated T cells and B lymphoblastoid cell lines (B-LCL) of patients exhibited aberrant protrusions and abnormal migration speed in confined channels concomitant with altered actin polymerization during migration. A DOCK11 knock-down recapitulated these abnormal cellular phenotypes in monocytes-derived dendritic cells (MDDC) and primary activated T cells from healthy controls. Lastly, in line with the patients’ autoimmune manifestations, we also observed abnormal regulatory T cells (Tregs) phenotype with profoundly reduced FOXP3 and IKZF2 expression. Moreover, we found a reduced T cell proliferation and an impaired STAT5B phosphorylation upon IL2 stimulation of the patients’ lymphocytes. In conclusion, DOCK11 deficiency is a new X-linked immune-related actinopathy leading to impaired CDC42 activity and STAT5 activation, and associated with abnormal actin cytoskeleton remodeling as well as Tregs phenotype culminating in immune dysregulation and severe early-onset autoimmunity

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)