Maestros en funciones

Este acto reflexivo merece iniciarse con la anécdota de Dyer (1992), la misma da cuenta de que un profesor le dice a sus compañeros que llevan más de 30 años dando clase, "¿Han estado ustedes realmente enseñando 30 años, o han estado enseñando un año 30 veces?" Reformulemos la cuestión: ¿La carpeta de nuestro trabajo áulico ha pasado a ser un invariante ―matemático con el transcurso de los años? ¿Cómo en diferentes grupos de alumnos de culturas institucionales disjuntas se exponen idénticas clases de matemática? La propuesta es tratar de intentar que cada hora de clase sea una función exclusiva de interacción entre alumnos y docentes, lo cual implica claro está, el desarrollo de un trabajo creativo en pos de cumplir con nuestra vocación. Si bien es cierto que cuando se habla de creatividad generalmente se piensa en las diversas expresiones del arte, y que pocas veces se ve a la matemática como un área creativa, el alcance de esta creatividad no se refiere solo al modo de utilizar los recursos sino también el tipo de actividades que han de proponerse. Rescatemos lo creativo de la matemática, alejemos esa idea de que el aprendizaje, para que se logre, tiene que ser desagradable, aburrido o formalísimo; no estamos hablando de incorporar ilustraciones absurdas en los textos para hacer creer que así es divertido aprender matemática, sino que se trata de otra cuestión mucho más profunda, queremos que cada alumno vaya construyendo su propio conocimiento

Tecnologías de la Información y la Comunicación para contextos educativos : Diseño y desarrollo de software específico. Metodologías, experiencias y aplicaciones

Se tiene como objetivo, en el marco de este subproyecto, realizar investigación en el área de Tecnología Informática aplicada a Educación. Esto involucra el diseño y desarrollo de herramientas informáticas que puedan tener un impacto desde el punto de vista educativo, así como también, la búsqueda de metodologías y estrategias didácticas que permitan tomar ventaja del uso de éstas en los procesos de enseñar y aprender. Se presentan en este trabajo, los objetivos, las líneas de investigación y los resultados referidos a este proyecto. En particular, se pondrá énfasis en los avances realizados durante el año 2009.Eje: Tecnología informática aplicada en educaciónRed de Universidades con Carreras en Informática (RedUNCI

Tecnologías de la Información y la Comunicación en ámbitos educativos: análisis de experiencias y resultados de su aplicación

Este subproyecto tiene como objetivo realizar investigación en áreas de Tecnología Informática aplicada a Educación. Se presentarán aquí los avances de éste respecto de los objetivos planteados y las líneas de investigación correspondientes.Como avances respecto del año 2011 se han obtenido títulos de Magister y de Especialización en Tecnología Informática Aplicada en Educación. Se han presentado propuestas de doctorado y se está trabajando con alumnos en varias tesinas de grado en temas vinculados al proyecto. De igual modo se han abordado diferentes experiencias de inclusión de tecnología en ámbitos educativos. Como resumen de lo realizado se abordaron los siguientes temas: - El desarrollo de metodologías para trabajo colaborativo usando TICs., - Avance en el desarrollo de las métricas e indicadores para medir la calidad de los procesos educativos mediados por tecnología. Análisis de las experiencias desarrolladas. - Análisis y desarrollo de materiales educativos multimediales e hipermediales. Análisis de ambientes educativos 3D. - Análisis e implementación de laboratorios virtuales y remotos. - Uso de la tecnología móvil integrada a entornos virtuales. - Investigación sobre entornos virtuales de enseñanza y aprendizaje y posibilidades que se generan a partir de su utilización. Se detallan las líneas de investigación y resultados obtenidos, en particular durante el año 2012.Eje: Tecnología Informática Aplicada en EducaciónRed de Universidades con Carreras en Informática (RedUNCI

Tecnologías de la Información y la Comunicación en ámbitos educativos

Se presentan en este trabajo los avances y resultados en relación al subproyecto antes mencionado. En particular, se focaliza el área de TIC aplicadas en el ámbito educativo. Dentro de esta área, se abordan procesos de investigación, desarrollo, innovación y transferencia a diferentes niveles de enseñanza. Este trabajo se nutre a partir de un equipo interdisciplinario, así como también de becarios y tesistas que abordan diferentes aristas en relación a la temática central del proyecto. Se estudian los paradigmas actuales en el diseño y desarrollo de materiales educativos, las oportunidades de los procesos colaborativos mediados por TIC, el impacto que pueden ofrecer estas tecnologías en escenarios de educación especial, los modelos existentes para evaluar calidad educativa, entre otros. Se detallan aquí los objetivos, las líneas de investigación y los resultados obtenidos, en particular durante el año 2011.Eje: Tecnología informática aplicada en educaciónRed de Universidades con Carreras en Informática (RedUNCI

Geohazard features of the north-western Sicily and Pantelleria

9 pages, 3 figures, supplemental material https://doi.org/10.1080/17445647.2024.2342931.-- Data availability statement: Department of Earth and Marine Science of the University of Palermo for institutional purposes, so their access will be available by contacting the reference people (attilio.sulliunipa.it) upon reasonable requestWe present maps of geohazard features identified across north-western Sicily and Pantelleria in the framework of the Magic project (MArine Geohazard along Italian Coasts), which involved Italian marine geological researchers in 2007-2013. These seafloor features were recognized using high-resolution bathymetry data and rely on the morphological expression of the seafloor and shallow sub-surface processes. The north-western Sicily is a complex continental margin, affected by morphodynamic, depositional, and tectonic processes. The Egadi offshore is controlled by fault escarpments and alternating retreating and progradational processes. Ustica and Pantelleria submerged edifices show the effect of volcanic activity. The Ustica seafloor is interested in volcanic, tectonic, and gravitational instability processes, while the Pantelleria offshore underwent erosive-depositional processes and the effect of bottom currents. Two levels of interpretation are represented: the physiographic domain at a scale of 1:250.000 and the morphological units and morpho-bathymetric elements at a 1:100.000 scaleThe Magic Project has been funded by the Italian Civil Protection Department. [...] With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

BACKGROUND: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. METHODS: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. FINDINGS: We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02-2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06-3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05-2·44; p=0·04) and Asp294His (2·15, 1·05-4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. INTERPRETATION: Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. FUNDING: SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831

Efeitos do uso de mangas de compressão gradual no desempenho muscular de homens treinados

Investigações têm demonstrado que o uso de roupas de compressão para membros inferiores pode melhorar a potência em saltos e a economia de corrida. Recentemente, o uso de roupas de compressão para os membros superiores tornou-se popular em desportos onde a força, resistência e potência muscular são requeridas. No entanto, os benefícios das roupas de compressão no desempenho muscular ainda precisam ser investigados. O objetivo do estudo foi investigar os efeitos de mangas de compressão na produção de força e no trabalho dos flexores do cotovelo. Participaram do estudo oito homens jovens e saudáveis com experiência em exercício resistido. Os testes foram conduzidos de forma aleatória com <em>design</em> contrabalanceado, sendo: 1) manga de compressão e 2) manga sem compressão (placebo). Foram avaliados o pico de torque (PT) e o trabalho total (TT) durante quatro séries de 10 repetições máximas dos flexores do cotovelo a 60°.s^-1 em dinamómetro isocinético. Verificou-se redução significativa do PT e TT entre as séries em ambas as condições. No entanto, não foram encontradas diferenças significativas entre compressão e placebo. Os resultados indicam que as mangas de compressão usadas por atletas e entusiastas não contribuem para aumento da força ou capacidade de realizar trabalho dos flexores do cotovelo

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Ferrari, Andrea/0000-0002-4724-0517; Pellegrini, Cristina/0000-0003-2168-8097; Migliano, Emilia/0000-0002-5316-8937; Maisonneuve, Patrick/0000-0002-5309-4704; Guida, Stefania/0000-0002-8221-6694; Pastorino, Lorenza/0000-0002-2575-8331; CARRERA, CRISTINA/0000-0003-1608-8820; Paillerets, Brigitte Bressac-de/0000-0003-0245-8608; Sekulovic, Lidija Kandolf/0000-0002-5221-5068; Caini, Saverio/0000-0002-2262-1102; Potrony, Miriam/0000-0003-2766-0765; Pizzichetta, Maria Antonietta/0000-0002-4201-8490; Little, Julian/0000-0001-5026-5531; Nagore, Eduardo/0000-0003-3433-8707; Polsky, David/0000-0001-9554-5289; Demenais, Florence/0000-0001-8361-0936; Nazzaro, Gianluca/0000-0001-8534-6497; gandini, sara/0000-0002-1348-4548; Cornelius, Lynn A/0000-0002-6329-2819; Palmieri, Giuseppe/0000-0002-4350-2276; Cotignola, Javier/0000-0003-4473-9854; Ghiorzo, Paola/0000-0002-3651-8173; Autier, Philippe/0000-0003-1538-5321; Bishop, Tim/0000-0002-8752-8785; Sera, Francesco/0000-0002-8890-6848; Newton-Bishop, Julia/0000-0001-9147-6802; Litchfield, Melisa/0000-0003-0002-7724WOS: 000464254100018PubMed: 30872112Background Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods in this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. Findings We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1.54, 95% CI 1.02-2.33), including when analysis was restricted to patients aged 18 years or younger (1.80, 1.06-3.07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1.60, 95% CI 1.05-2.44; p=0.04) and Asp294His (2.15, 1.05-4.40; p=0.04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. Interpretation Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. Copyright (c) 2019 Elsevier Ltd. All rights reserved.[AIRC-MFAG-11831]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086] Funding Source: NIH RePORTERSPD-Pilot/Project-Award-2015; AIRC-MFAG-11831

Foraminiferal record and high-resolution seismic stratigraphy of the Late Holocene succession of the submerged Ombrone River delta (Northern Tyrrhenian Sea, Italy)

Micropalaeontological data integrated with radiocarbon dates and seismic profiles allow for a reconstruction of the Late Holocene evolution of the Ombrone River delta area during the last 6.0 ka. Seven cores collected in three distinct sectors of the submerged Ombrone delta were studied: the delta front (cores NK7, NK8, BOK5 and BOK10) and prodelta slope (core NK4), which are primarily affected by river input, and the middle shelf (cores NK2 and NK3), which is progressively less influenced by riverine impact. Seismostratigraphic interpretation indicated that the majority of the cores intercepted the most recent deposits of the late Quaternary depositional sequence (unit A), whose base is dated at 2.8 ± 100 ka BP. The deepest and shallowest cores reveal a record of the ancient and the most recent evolution of the succession, respectively, although the most complete palaeoenvironmental evidence comes from the middle shelf (core NK2) and prodelta slope (core NK4). The oldest sedimentary phase is indicated by benthic foraminiferal assemblages and seismic profiles of the middle shelf core and correlates with the Late Transgressive Systems Tract (unit B). The following phase is attributed to the Highstand Systems Tract (unit A) and spans the last 3.0 ka. Hierarchical cluster analysis (HCA) (Q-mode) of the benthic foraminifera in the cores resulted in 10 foraminiferal assemblages that correspond to four distinct environments with various degrees of river influence. © 2013 Elsevier Ltd and INQUA

Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas

The association of clinical and dermoscopic features with BRAF mutational status has been poorly analysed in multiple primary melanomas (MPM)