Posterior Subtalar Dislocation

A subtalar dislocation of the foot is an uncommon injury, and cases of posterior subtalar dislocation are even rarer. This injury is characterized by a simultaneous dislocation of talocalcaneal and talonavicular joints while tibiotalar and calcaneocuboid articulations remain intact. Subtalar dislocation is commonly accompanied by fractures of the malleoli, talus, or fifth metatarsal and by a rotational component of the subtalar joint. Subtalar dislocation can occur in any direction and produces significant deformity. This article presents a case of pure posterior subtalar dislocation in an 80-year-old man who presented with pain and deformity in his left ankle following a motorcycle accident. Radiographs demonstrated dislocation of both the talonavicular and talocalcaneal joints. The calcaneus was displaced posteriorly without medial or lateral displacement. No rotational component of the calcaneus was noted, suggesting the trauma was in pure hyperplantar flexion. We hypothesize that pure hyperplantar flexion could lead to a progressive subtalar ligament weakening that may result in a complete ligament rupture if the plantar flexion force is prolonged. This could be observed in the presence of good bone quality and if the force is applied distally at the navicular bone

The collapse of the Morandi bridge in Genoa on 14 august 2018: A collective traumatic event and its emotional impact linked to the place and loss of a symbol

The collapse of the Morandi bridge in Italy, which took place in the summer of 2018, has had enormous emotional, economic, and social consequences for the inhabitants of the area, which are felt throughout the world. As seen in the literature, collective traumatic events increase the experience of insecurity and paranoia, thus increasing the perception of vulnerability. The present work aims to bring out the emotions most experienced by the participants connected to the traumatic event in question, paying attention to the possible solutions to be proposed to local stakeholders from a sustainability perspective, this way favouring community empowerment. The research, carried out with the photovoice technique, involved 30 young adults residing in areas near the event. The results illustrate how the participants experienced mainly feelings of emptiness, vulnerability, and fear as well as anger, despair, and mistrust of the institutions. It was also stressed that the economic and structural hardships hit the inhabitants hard. There have been many concrete solutions identified by the participants: creating a support network, supporting the local economy, and keeping the memory alive. The research and application implications underline the importance of using photovoice within community interventions, a tool that facilitates awareness and active citizenship

From Geophysics to Microgeophysics for Engineering and Cultural Heritage

The methodologies of microgeophysics have been derived from the geophysical ones, for the sake of solving specific diagnostic and/or monitoring problems regarding civil engineering and cultural heritage studies. Generally, the investigations are carried out using different 2D and 3D tomographic approaches as well as different energy sources: sonic and ultrasonic waves, electromagnetic (inductive and impulsive) sources, electric potential fields, and infrared emission. Many efforts have been made to modify instruments and procedures in order to improve the resolution of the surveys as well as to significantly reduce the time of the measurements without any loss of information. This last point has been achieved by using multichannel systems. Finally, some applications are presented, and the results seem to be very promising and promote this new branch of geophysics. Therefore, these methodologies can be used even more to diagnose, monitor, and safeguard not only engineering buildings and/or large structures, but also ancient monuments and cultural artifacts, such as pottery, statues, and so forth

Investigación sobre un pasteurizador de túnel para las aceitunas de mesa “Nocellara del Belice” procesadas mediante el “Método Castelvetrano”

The influence of pasteurization temperature and time of treatment on the flesh firmness and the evolution of microbial communities was studied for table olives Cv. Nocellara del Belice, packed in glass jars and processed with a tunnel pasteurizer. The experiment was first carried out on the laboratory level in order to select the optimal combination of pasteurization time/temperature so as to obtain the proper balance between the consistency of the pulp and the microbiological quality of the final product. Pasteurization at industrial scale was then carried out in a tunnel pasteurizer applying the treatment at 75 °C for 8 min in the thermal center of the jars. Besides flesh firmness and microbial evolutions, the pH, total titratable acidity (TTA) and color were evaluated for the table olives during storage at 6, 12 and 15 months from packing. The table olives showed a high stability and acceptable flesh firmness for the entire period under observation. Specifically, olive pulp texture decreased during the storage period, but the softening was most evident in the deeper layers of the pulp. The results indicated that the storage period should not exceed 6 months. Although the hygiene is preserved, after this period the firmness might not be acceptable to consumers.En el presente trabajo se estudió la influencia de la temperatura y del tiempo de pasteurización en la firmeza de la pulpa y la evolución de las comunidades microbianas para la aceituna de mesa “Nocellara del Belice” procesadas con un pasteurizador de túnel. El experimento se llevó a cabo preliminarmente a nivel de laboratorio con el fin de seleccionar la combinación óptima de tiempo/temperatura de pasteurización para obtener el compromiso adecuado entre la consistencia de la pulpa y la calidad microbiológica del producto final. A continuación se llevó a cabo la pasteurización en escala industrial dentro de un pasteurizador de túnel aplicando el tratamiento a 75 ° C durante 8 minutos. Fueron evaluados pH, acidez total titulable (ATT) y el color para las aceitunas de mesa durante el almacenamiento a los 6, 12 y 15 meses de envasado. Las aceitunas de mesa mostraron una alta estabilidad y una firmeza de pulpa aceptable para todo el período de observación; en particular, la textura de pulpa disminuyó durante el período de almacenamiento, pero el ablandamiento fue más evidente en las capas más profundas de la pulpa. Los resultados indicaron que el período de almacenamiento no debe ser superior a 6 meses

Geophysical Constraints to Reconstructing the Geometry of a Shallow Groundwater Body in Caronia (Sicily)

The characterization of a groundwater body involves the construction of a conceptual model that constitutes the base knowledge for monitoring programs, hydrogeological risk assessment, and correct management of water resources. In particular, a detailed geological and geophysical approach was applied to define the alluvial Caronia Groundwater Body (CGWB) and to reconstruct a hydrogeological flow model. The analysis of the CGWB, located in north-eastern Sicily, was initially approached through a reanalysis of previous stratigraphic (boreholes) and geophysical (vertical electrical soundings and seismic refraction profiles) data, subsequently integrated by new seismic acquisitions, such as Multichannel Analysis of Surface Waves (MASW) and horizontal-to-vertical seismic ratio (HVSR). The analysis and reinterpretation of geoelectrical data allowed the construction of a preliminary 3D resistivity model. This initial modeling was subsequently integrated by a geophysical data campaign in order to define the depth of the bottom of the shallow CGWB and the thickness of alluvial deposits. Finally, a preliminary mathematical model flow was generated in order to reconstruct the dynamics of underground water. The results show that integration of multidisciplinary data represent an indispensable tool for the characterization of complex physical systems

Radiomics in cervical and endometrial cancer

Radiomics is an emerging field of research that aims to find associations between quantitative information extracted from imaging examinations and clinical data to support the best clinical decision. In the last few years, some papers have been evaluating the role of radiomics in gynecological malignancies, mainly focusing on ovarian cancer. Nonetheless, cervical cancer is the most frequent gynecological malignancy in developing countries and endometrial cancer is the most common in western countries, The purpose of this narrative review is to give an overview of the latest published papers evaluating the role of radiomics in cervical and endometrial cancer, mostly evaluating association with tumor prognostic factors, with response to therapy and with prediction of recurrence and distant metastasis

In silico identification of small molecules as new cdc25 inhibitors through the correlation between chemosensitivity and protein expression pattern

The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed ligand-structure-based approach and taking advantage of the correlation between the chemosensitivity of selected structures and the protein expression pattern of the proposed target. In the first step of the in silico protocol, a set of molecules acting as Cdc25 inhibitors were identified through a new ligand-based protocol and the evaluation of a large database of molecular structures. Subsequently, induced-fit docking (IFD) studies allowed us to further reduce the number of compounds biologically screened. In vitro antiproliferative and enzymatic inhibition assays on the selected compounds led to the identification of new structurally heterogeneous inhibitors of Cdc25 proteins. Among them, J3955, the most active inhibitor, showed concentration-dependent antiproliferative activity against HepG2 cells, with GI50 in the low micromolar range. When J3955 was tested in cell-cycle perturbation experiments, it caused mitotic failure by G2/M-phase cell-cycle arrest. Finally, Western blotting analysis showed an increment of phosphorylated Cdk1 levels in cells exposed to J3955, indicating its specific influence in cellular pathways involving Cdc25 proteins

Experimental Study of the Pygmy Dipole Resonance in the 68Ni Nucleus

It is known that the low-energy E1 strength, known as the Pygmy Dipole Resonance (PDR), can be excited by both isovector and isoscalar probes. In this work, we report on the results of an experiment, carried out at the LNS-INFN in Catania, with the aim to study the Pygmy Dipole Resonance induced in the 68Ni nucleus through the interaction with a 12C isoscalar target. The CHIMERA multidetector and the FARCOS array were used to detect, respectively, γ rays and charged particles. Details on the experimental set-up, data analysis and results are reported