Circular Bedforms Due to Pit Foraging of Greater Flamingo Phoenicopterus roseus in a Back-barrier Intertidal Habitat

The Greater Flamingo Phoenicopterus roseus is known as an ecosystem engineer, rearranging sediment in peculiar bedforms as a consequence of its filter-feeding behaviour. In recent decades, the populations of the Greater Flamingo have notably increased, and now the species is one of the most abundant waterbirds in Mediterranean wetlands. Owing to its range expansion, it inhabits and exploits new and suitable foraging sites detectable by foraging structures left on the sediment. There are few images of the foraging morphologies in the literature, possibly due to their ephemeral nature and difficulty in detecting them. In this manuscript, we present a very detailed UAV (Unmanned Aerial Vehicle) image of an aggregate of pit foraging structures of Greater Flamingo discovered on a back-barrier washover fan in the Marano and Grado Lagoon (Northern Adriatic, Italy)

ON-LINE CONSISTENCY TESTS FOR BAR DETECTORS

In order to detect gravitational wave signals with resonant bar detectors using Wiener–Kolmogorov (WK) filters, both a model for the power spectrum density (PSD) of the noise and a signal template should be provided. As the analysis is not meant to handle non-gaussian data, we have to discriminate (and constrain to) time periods where the noise follows a quasi-stationary gaussian model. Within these periods, candidate events are selected in the WK filter output, and their fundamental parameters (time of arrival and amplitude) are computed. A necessary and sufficient condition for the reliability of such estimates is the consistency of the signal shape with the template. This is done performing a goodness-of-the-fit test

Testing of optimal filters for gravitational wave signals: An experimental implementation

We have implemented likelihood testing of the performance of an optimal filter within the online analysis of AURIGA, a sub-Kelvin resonant-bar gravitational wave detector. We demonstrate the effectiveness of this technique in discriminating between impulsive mechanical excitations of the resonant-bar and other spurious excitations. This technique also ensures the accuracy of the estimated parameters such as the signal-to-noise ratio. The efficiency of the technique to deal with non-stationary noise and its application to data from a network of detectors are also discussed

Optimal management of constipation associated with irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common chronic functional disorder of the gastrointestinal tract, meanly characterized by recurrent abdominal pain or discomfort and altered bowel habit. It is a complex disorder involving biological, environmental, and psychosocial factors. The diagnosis is achieved according to the Rome III criteria provided that organic causes have been excluded. Although IBS does not constitute a life-threatening condition, it has a remarkable prevalence and profoundly reduces the quality of life with burdening socioeconomic costs. One of the principal concerns about IBS is the lack of effective therapeutic options. Up to 40% of patients are not satisfied with any available medications, especially those suffering from chronic constipation. A correct management of IBS with constipation should evolve through a global approach focused on the patient, starting with careful history taking in order to assess the presence of organic diseases that might trigger the disorder. Therefore, the second step is to examine lifestyle, dietary habits, and psychological status. On these bases, a step-up management of disease is recommended: from fiber and bulking agents, to osmotic laxative drugs, to new molecules like lubiprostone and linaclotide. Although new promising tools for relief of bowel-movement-related symptoms are being discovered, a dedicated doctor-patient relationship still seems to be the key for success

Initial operation of the International Gravitational Event Collaboration

The International Gravitational Event Collaboration, IGEC, is a coordinated effort by research groups operating gravitational wave detectors working towards the detection of millisecond bursts of gravitational waves. Here we report on the current IGEC resonant bar observatory, its data analysis procedures, the main properties of the first exchanged data set. Even though the available data set is not complete, in the years 1997 and 1998 up to four detectors were operating simultaneously. Preliminary results are mentioned.Comment: 8 pages, 2 figures, 3 tables; Proceeding of the GWDAW'99. Submitted to the International Journal of Modern Physic

Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

: Sickle cell disease and β-thalassemia affect the production of the adult β-hemoglobin chain. The clinical severity is lessened by mutations that cause fetal γ-globin expression in adult life (i.e., the hereditary persistence of fetal hemoglobin). Mutations clustering ~200 nucleotides upstream of the HBG transcriptional start sites either reduce binding of the LRF repressor or recruit the KLF1 activator. Here, we use base editing to generate a variety of mutations in the -200 region of the HBG promoters, including potent combinations of four to eight γ-globin-inducing mutations. Editing of patient hematopoietic stem/progenitor cells is safe, leads to fetal hemoglobin reactivation and rescues the pathological phenotype. Creation of a KLF1 activator binding site is the most potent strategy - even in long-term repopulating hematopoietic stem/progenitor cells. Compared with a Cas9-nuclease approach, base editing avoids the generation of insertions, deletions and large genomic rearrangements and results in higher γ-globin levels. Our results demonstrate that base editing of HBG promoters is a safe, universal strategy for treating β-hemoglobinopathies

Status report of the gravitational wave detector AURIGA

We present the status of the ultracryogenic gravitational wave detector AURIGA, which is taking data since may 1997 with an energy sensitivity in the mK range and bandwidth greater than 1 Hz. The typical detector output is summarized in daily reports which are important tools for detector diagnostic and for checking the vetoes of periods of unsatisfactory operation of the detector

Younger age at onset and sex predict celiac disease in children and adolescents with type 1 diabetes: an Italian multicenter study

OBJECTIVE— To estimate the prevalence of biopsy-confirmed celiac disease in Italian children and adolescents with type 1 diabetes and to assess whether age at onset of type 1 diabetes is independently associated with diagnosis of celiac disease. RESEARCH DESIGNANDMETHODS— The study group was a clinic-based cohort of children and adolescents with type 1 diabetes cared for in 25 Italian centers for childhood diabetes. Yearly screening for celiac disease was performed using IgA/IgG anti-gliadin and IgA anti-endomysium antibodies. RESULTS— Of the 4,322 children and adolescents (age 11.8 4.2 years) identified with type 1 diabetes, biopsy-confirmed celiac disease was diagnosed in 292 (prevalence 6.8%, 95% confidence interval [CI] 6.0 –7.6), with a higher risk seen in girls than in boys (odds ratio [OR] 1.93, 1.51–2.47). In 89% of these, diabetes was diagnosed before celiac disease. In logistic regression analyses, being younger at onset of diabetes, being female, and having a diagnosis of a thyroid disorder were independently associated with the risk of having diabetes and celiac disease. In comparison with subjects who were older than 9 years at onset of diabetes, subjects who were younger than 4 years at onset had an OR of 3.27 (2.20–4.85). CONCLUSIONS— We have provided evidence that 1) the prevalence of biopsy-confirmed celiac disease in children and adolescents with type 1 diabetes is high (6.8%); 2) the risk of having both diseases is threefold higher in children diagnosed with type 1 diabetes at age 4 years than in those age 9 years; and 3) girls have a higher risk of having both diseases than boys