Octal Bent Generalized Boolean Functions

In this paper we characterize (octal) bent generalized Boolean functions defined on \BBZ_2^n with values in \BBZ_8. Moreover, we propose several constructions of such generalized bent functions for both $n$ even and $n$ odd

Skin Admittance Measurement for Emotion Recognition: A Study over Frequency Sweep

The electrodermal activity (EDA) is a reliable physiological signal for monitoring the sympathetic nervous system. Several studies have demonstrated that EDA can be a source of effective markers for the assessment of emotional states in humans. There are two main methods for measuring EDA: endosomatic (internal electrical source) and exosomatic (external electrical source). Even though the exosomatic approach is the most widely used, differences between alternating current (AC) and direct current (DC) methods and their implication in the emotional assessment field have not yet been deeply investigated. This paper aims at investigating how the admittance contribution of EDA, studied at different frequency sources, affects the EDA statistical power in inferring on the subject?s arousing level (neutral or aroused). To this extent, 40 healthy subjects underwent visual affective elicitations, including neutral and arousing levels, while EDA was gathered through DC and AC sources from 0 to 1 kHz. Results concern the accuracy of an automatic, EDA feature-based arousal recognition system for each frequency source. We show how the frequency of the external electrical source affects the accuracy of arousal recognition. This suggests a role of skin susceptance in the study of affective stimuli through electrodermal response

Accelerating Monte Carlo simulations with an NVIDIA® graphics processor

Modern graphics cards, commonly used in desktop computers, have evolved beyond a simple interface between processor and display to incorporate sophisticated calculation engines that can be applied to general purpose computing. The Monte Carlo algorithm for modelling photon transport in turbid media has been implemented on an NVIDIA® 8800gt graphics card using the CUDA toolkit. The Monte Carlo method relies on following the trajectory of millions of photons through the sample, often taking hours or days to complete. The graphics-processor implementation, processing roughly 110 million scattering events per second, was found to run more than 70 times faster than a similar, single-threaded implementation on a 2.67 GHz desktop computer

Decomposing generalized bent and hyperbent functions

In this paper we introduce generalized hyperbent functions from $F_{2^n}$ to $Z_{2^k}$, and investigate decompositions of generalized (hyper)bent functions. We show that generalized (hyper)bent functions from $F_{2^n}$ to $Z_{2^k}$ consist of components which are generalized (hyper)bent functions from $F_{2^n}$ to $Z_{2^{k^\prime}}$ for some $k^\prime < k$. For odd $n$, we show that the Boolean functions associated to a generalized bent function form an affine space of semibent functions. This complements a recent result for even $n$, where the associated Boolean functions are bent.Comment: 24 page

An Appropriate English-learning Activity for Japanese University Students - A Case Study of Shinshu University Students -

Article信州大学教育学部紀要. 76: 63-71 (1992)departmental bulletin pape

Minutes of the General Assembly

Minutes of the General Assembl

Development of CRISPR screenable phenotypes for PCV2 in pig cells and detection of latent BVDV contamination in commercial FBS

Genome-wide CRISPR screening er et kraftig forskningsverktøy som gjør det mulig å undersøke virkningen av spesifikke gener i ulike biologiske prosesser, som for eksempel overlevelsesevne, fenotypeutvikling eller sykdomsprosesser. Ved å bruke CRISPR-teknologi for å slå ut eller modifisere gener, kan forskere identifisere potensielle mål for legemidler eller avdekke ny innsikt i cellulære mekanismer. Dette studiet er en del av et større prosjekt der hovedmålet er å oppdage genkandidater som gir griser resistens mot PCV2 ved bruk av Genome-wide CRISPR knockout screening (GeCKO) som er et verktøy for mer presis og effektiv avl. Studiet hadde som mål å utvikle en protokoll for dyrking av PCV2 i PK-15 celler og identifisere en passende cellelinje med detekterbare cytopatiske effekter ved infeksjon av PCV2. prosjektet. I tillegg ønsket vi å finne en BVDV-fri kilde til FBS for å forhindre kontaminasjon i MDBK-celler, en cellelinje som vil bli brukt i GeCKO screening. Evaluering av levedyktighet i PK-15 celler infisert med PCV2 viste tilstedeværelse av virusinduserte cytopatiske effekter, spesielt ved lavere celletetthet. Det er nødvendig med ytterligere optimalisering og oppskalering av den eksperimentelle prosedyren for å sikre reproduserbare og pålitelige resultater for GeCKO screeningapplikasjoner. Vi forsøkte å utvikle en screenbar fenotype basert på virusinduserte aktinforandringer, men disse eksperimentene var mislykkede og krever optimalisering av prosedyre. Vi avdekket betydelige forskjeller i cellevekst og levedyktighet i PK-15-celler infisert med PCV2 sammenlignet med mock infiserte celler, noe som indikerer den betydelige effekten av PCV2-infeksjon på cellulær helse. PCR og agarose gelelektroforese bekreftet tilstedeværelsen av PCV2 i infiserte PK-15 celler, og Real-Time PCR hadde vellykket amplifisering av PCV2 viralt DNA og viste suksessfull virusreplikasjon. BVDV kontaminasjon ble identifisert i den første analysen av MDBK celler dyrket med forskjellige FBS batcher. Påfølgende testing ved hjelp av en BVDV-fri MDBK cellelinje bekreftet FBS som kilden til kontaminasjon. En BVDV-fri batch av FBS ble innhentet og løste kontamineringsproblemet for fremtidig bruk i GeCKO screening. Forskningen i dette studiet bidrar til utvikling av CRISPR-verktøy for produksjonsdyr og legger grunnlaget for flere genredigeringsmuligheter, noe som potensielt kan føre til bedre dyrehelse og kostnadsbesparelser i avlsindustrien.Genome-wide CRISPR screening is a powerful research tool that enables scientists to investigate the roles of specific genes in various biological processes, such as cell survival, phenotype development, or disease pathways. By using CRISPR technology to knockout or modify genes on a genome-wide scale, researchers can identify potential drug targets or uncover novel insights into cellular mechanisms. This study is a part of a bigger project where the main goal is to discover gene candidates for PCV2 resistance in pigs using genome-wide CRISPR knockout screening (GeCKO) as a tool for more precise and efficient breeding. This study aims to develop a protocol for PCV2 cultivation in PK-15 cells and identify a suitable cell line with detectable cytopathic effects upon infection. In addition, the study sought to find a BVDV-free source of FBS to prevent contamination in MDBK cells, a cell line that will be used in GeCKO screening. The evaluation of cell viability in PCV2 infection experiments demonstrated the presence of viral-induced cytopathic effects, particularly at lower cell densities. However, further optimization and scaling up of the experimental procedure are needed to ensure reproducibility and reliability for GeCKO screening applications. We attempted to develop a screenable phenotype based on virus mediated actin remodeling, however these experiments were unsuccessful, and require optimization of the method. We revealed significant differences in cell growth and viability in PK-15 cells infected with PCV2 compared to mock infected cells, indicating the substantial impact of PCV2 infection on cellular health. PCR and agarose gel electrophoresis confirmed the presence of PCV2 in infected PK-15 cells, and Real-Time PCR demonstrated successful amplification of PCV2 viral DNA showing successful replication. BVDV contamination was identified in the initial testing of MDBK cells grown with different FBS batches. Subsequent testing using a BVDV-free MDBK cell line confirmed FBS as the source of contamination. A BVDV-free batch of FBS was obtained, resolving the contamination issue for future use in GeCKO screening. This research contributes to the development of CRISPR tools for production animals, paving the way for more gene-editing possibilities and potentially leading to better animal health and cost savings in the breeding industry