32 research outputs found

    WEARABLE ELECTRONICS FOR CLOTHES THE PURPOSE OF MONITORING THE POSITION WEARER OF THE APPAREL

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    50 s. :obr. +CD ROMTato bakalářská práce se zabývá studiem ''Smart'' materiálů a snímacích systémů. Je hlavně zaměřena na monitorování polohy nositele v reálném čase. Systém byl testován z pohledu různých lokalitách, tak vlivu stínění různých materiálů na výkon sledovací jednotky. K testování byli vybrány tři sledovací jednotky a jejich případné uplatnění u Horské služby, Hasického zboru nebo Horské služby

    Decrease Scrap Rate and Increase Productivity in Production of Chips

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    Import 04/07/2011Diplomová práce se zabývá snížením zmetkovitosti a zvýšením produktivity při výrobě čipů. Úvodem se věnuji teorii PTC a následně se zaměřuji na všechny výrobní procesy od popsání procesu, analýzy současného stavu, příčiny zmetkovitosti a následného zavedení nápravných opatření. Součástí diplomové práce je také zvýšení produktivity na výrobních usecích, které byly z hlediska nárůstu objednávek limitující. K vyhodnocení dat a prezentaci zjištěných údajů byl použit statistický program Minitab.Master thesis is dealing with decrease scrap rate and increasing of the productivity in production of chips. At the beginning of thesis there are basic informations about PTC and after it I’m focusing on production processes from the decription, analysis of actual situation, causes of scrap rate and implementation of the preventive actions. Part of the thesis is also increasing of the productivity in processes, which were because of increasing of orders limiting. To the evaluation of data and presentation of founded statements was used statistic program Minitab.345 - Katedra mechanické technologievýborn

    Aplikace nositelné elektroniky a senzorů do profesních oděvů a oděvů pro volný čas

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    Disertační práce se zabývá Aplikací nositelné elektroniky s možnostmi monitorování životních funkcí, mezi které patří krevní tlak, tepová frekvence, teplota pokožky, vlhkost pokožky nebo dechová frekvence. Tato disertační práce se zaměřuje právě na možnosti monitorování dechové frekvence a její následné vyhodnocení, a to za pomoci nositelné elektroniky aplikované do první vrstvy oděvu a následné zkoumání závislosti změny dechové frekvence s nastupující únavou organizmu.This dissertation deals with the application of wearable electronics with the ability to monitor vital signs including blood pressure, heart rate, skin temperature, skin moisture, and respiratory rate. This dissertation focuses specifically on the possibilities of breathing rate monitoring and its subsequent evaluation, using wearable electronics applied to the first layer of clothing and then investigating the relationship of breathing rate change with the onset of body fatigue

    The effect of cadmium-nickel interactions on superoxide production, cell viability and membrane potential (E<sub>M</sub>) in roots of two maize cultivars

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    Effects of CdCl2, NiCl2 or both on superoxide production, viability and membrane potential (EM) of root cells in meristematic (MZ) and differentiation (DZ) zones of two maize cultivars (cv. Premia and cv. Blitz) were studied. Plants were supplied with 10 and 100 μM concentrations of heavy metals (HM). The responses in the studied parameters to HM were concentration- and time-dependent, and were found only in the cells of MZ. The treatment of roots with Cd-stimulated massive superoxide production, although to different extent depending on the cultivar, root zone, and metal concentration. The stimulating effect of Ni on oxidative burst in Cd-treated maize roots was related to an increased Cd-induced superoxide production. The cell death appeared between 24 and 48 h and between 12 and 24 h of the 10 μM and 100 μM metal treatments, respectively. This was in accordance with Cd-induced ROS (superoxide) production and the EM decline in the corresponding time periods. Cell viability, EM changes and partially superoxide production indicate that the impact of the metals on the studied parameters declined in the order Cd+Ni > Cd > Ni and that cv. Blitz tends to respond more sensitively than cv. Premia

    Impact of nickel on grapevine (Vitis vinifera L.) root plasma membrane, ROS generation, and cell viability

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    The present study investigated the impact of nickel (Ni2+) on trans- membrane electrical potential (EM) and permeability properties of plasma membrane (PM) in epidermal cells of adventitious grapevine roots. The relationship between disturbances of membrane functionality and the production of superoxide anion, hydrogen peroxide and cell viability after the exposure of roots to Ni2+ was also studied. Treatments with 0.1–5 mmol L–1 NiCl2 induced a concentration-dependent transient PM depolarization, which was recovered to the initial resting potential within 50–70 min in the presence of Ni2+. Longer (up to 24 h) exposure of roots to 1 mmol L–1 of Ni2+ hyperpolarized the EM by approximately 17 mV. Application of the highest 5 mmol L–1 concentration of Ni2+ during longer treatments (up to 48 h) resulted in the increase of membrane permeability; however the EM, cell viability, and superoxide content remained unaffected. The increase in the formation of hydrogen peroxide was time- and concentration- dependent and maximum production was recorded after 180 min of Ni2+ treatment. We can conclude that oxidative stress resulting from an imbalance in the generation and/or removal of hydrogen peroxide in the root tissues of grapevine was the major cause of Ni2+ toxicity

    Formation of silica aggregates in sorghum root endodermis is predetermined by cell wall architecture and development

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    Background and Aims Deposition of silica in plant cell walls improves their mechanical properties and helps plants to withstand various stress conditions. Its mechanism is still not understood and silica-cell wall interactions are elusive. The objective of this study was to investigate the effect of silica deposition on the development and structure of sorghum root endodermis and to identify the cell wall components involved in silicification. MethodsSorghum bicolor seedlings were grown hydroponically with (Si+) or without (Si-) silicon supplementation. Primary roots were used to investigate the transcription of silicon transporters by quantitative RT-PCR. Silica aggregation was induced also under in vitro conditions in detached root segments. The development and architecture of endodermal cell walls were analysed by histochemistry, microscopy and Raman spectroscopy. Water retention capability was compared between silicified and non-silicified roots. Raman spectroscopy analyses of isolated silica aggregates were also carried out. Key Results Active uptake of silicic acid is provided at the root apex, where silicon transporters Lsi1 and Lsi2 are expressed. The locations of silica aggregation are established during the development of tertiary endodermal cell walls, even in the absence of silicon. Silica aggregation takes place in non-lignified spots in the endodermal cell walls, which progressively accumulate silicic acid, and its condensation initiates at arabinoxylan-ferulic acid complexes. Silicification does not support root water retention capability; however, it decreases root growth inhibition imposed by desiccation. Conclusion A model is proposed in which the formation of silica aggregates in sorghum roots is predetermined by a modified cell wall architecture and takes place as governed by endodermal development. The interaction with silica is provided by arabinoxylan-ferulic acid complexes and interferes with further deposition of lignin. Due to contrasting hydrophobicity, silicification and lignification do not represent functionally equivalent modifications of plant cell walls

    2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes

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    Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

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    BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

    Increasing of surface grinding productivity

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    Import 02/08/2007Prezenční346 - Katedra obrábění a montáž
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