4 research outputs found
Current insights into the molecular systems pharmacology of lncRNA-miRNA regulatory interactions and implications in cancer translational medicine
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2016
- Field of study
Recommended from our members
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
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- Abedalthagafi M
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- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)
Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.
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- Sena-Ruiz F
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- Suresh S
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- Tan Y
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- Tarantino M
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- Zigiotto D
- Zijlmans Jl
- Zimmerman D
- Ziprin P
- Zope S
- Zuhair M
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
AIM:
Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.
METHODS:
This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.
RESULTS:
This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients.
CONCLUSIONS:
In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
- Author
- Aarts E
- Abbas Z
- Abburu S
- Abd Ghaffar Mk
- Abdelgalil R
- Abdelhadi M
- Abdikadir Hr
- Abdulmajid A
- Abdulrahman N
- Abid A
- Abid H
- Abrisqueta Carrion J
- Abuhussein N
- Abul Mh
- Acar S
- Acherman Yiz
- Acquaah F
- Acres M
- Adams R
- Adams Rd
- Adebayo Aa
- Adeleja I
- Adiyaman C
- Adjei H
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- Afzal Z
- Agalar C
- Agarwal V
- Agrawal M
- Ahern N
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- Ahmed N
- Ahmed S
- Ahn Js
- Aidoo-Micah Ge
- Aildasani L
- Aithie Jm
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- Akcaoglu T
- Akdogan A
- Akhtar S
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- Aksoy K
- Aktas Mk
- Aktekin H
- Al-Mousawi A
- Al-Nasser A
- Al-Nasser Z
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- Albayrak D
- Alberdi San Roman I
- Alberti Delgado P
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- Hudson-Phillips S
- Hughes Ba
- Hughes F
- Hughes Rk
- Hulley K
- Hung G
- Hurný M
- Hurst Pc
- Huseynova S
- Husnoo Sb
- Hussain N
- Hussain O
- Hutchings I
- Huzmeli E
- Ibrahim A
- Ibrahim I
- Ilbak A
- Inci Et
- Ingham R
- Ingram E
- Innocenti P
- Iorga R
- Iqbal A
- Iqbal S
- Isaac A
- Isler Vc
- Iyer S
- Jackson Hr
- Jackson S
- Jacob L
- Jafree Dj
- Jaitley A
- Jalota P
- Jamal N
- Janssen Tl
- Jaroš J
- Jathanna N
- Jawad As
- Jayakody N
- Jenkin Sl
- Jenvey C
- Jewell Pd
- Jeyabraba S
- Jhala H
- Jimenez Escovar F
- Jimenez-Gomez Lm
- Jimenez-Segovia M
- Jiménez-Morillas P
- Jiménez-Viñas C
- Jindal A
- Johnston A
- Johnston J
- Johnstone M
- Jones Cs
- Jong N
- Jordan Hem
- Joshi D
- Joshi Kr
- Joyce Hl
- Joyner C
- Jubainville Cl
- Jull P
- Jurgens J
- Kabariti R
- Kadicheeni M
- Kahar A
- Kakil E
- Kalra N
- Kamarajah Sk
- Kanabar S
- Kane T
- Kankam Hkn
- Kara B
- Kara C
- Kara E
- Karabacak U
- Karabulut E
- Karahan B
- Karia M
- Karia P
- Karsan Rb
- Karunakaran P
- Karásek D
- Kasap S
- Kasar P
- Kaushal A
- Kaya A
- Kayacan S
- Kayaci Durak M
- Kazmi Z
- Keane Cp
- Keane N
- Keane P
- Kee Jy
- Keeling Re
- Keelty N
- Keevil H
- Kelesoglu Y
- Kelly M
- Kelly Me
- Kelly N
- Kennedy Ed
- Kennedy Hr
- Kerai A
- Kerimova N
- Kerin Mj
- Kerr Al
- Keyif Mf
- Khaing Ph
- Khajuria A
- Khalid H
- Khan A
- Khan I
- Khan M
- Khan S
- Khan T
- Khan U
- Khangura J
- Khanijau R
- Khatri C
- Khattak M
- Khetarpal Aa
- Khokhar Ha
- Khonat Z
- Khonsari P
- Kiely A
- Kiff R
- Kilic E
- Kilinc C
- Kim Jw
- Kim S
- Kimani L
- King M
- Kip M
- Kishore A
- Kisyov I
- Kitt H
- Kleine E
- Klinkert M
- Kloppenberg Fwh
- Knight Cl
- Kobal Bb
- Koc Ge
- Kocapinar S
- Kocer Md
- Koksal G
- Koksal S
- Kong C
- Kong Cy
- Konsten J
- Kopac O
- Koppe M
- Kosasih Sr
- Koshy Rm
- Kotecha D
- Koumpa F
- Kow K
- Koysombat K
- Koç F
- Koç M
- Kreibich A
- Kretzmer L
- Kucukdiler E
- Kuiper J
- Kuiper Sz
- Kullac S
- Kumar An
- Kumaran G
- Kurklu O
- Kurt A
- Kuzey A
- Kwan Ml
- Kwang P
- Laguna Román S
- Lakhani M
- Lakhani Sm
- Lakshmipathy G
- Lalor P
- Lamont J
- Langenhoff B
- Lankage Cm
- Lap Cr
- Larotonda C
- Laterza V
- Latras-Cortés I
- Laurino A
- Lavery J
- Lazenby D
- Leafe O
- Ledsam A
- Lee Ahy
- Lee J
- Lee S
- Lees Dm
- Lek C
- Leong S
- Leslie Ke
- Leung W
- Leventoglu S
- Lewis T
- Li Hi Shing S
- Li Mm
- Li N
- Licari L
- Liew W
- Liew Y
- Lim Ae
- Lim D
- Lim E
- Lim J
- Lim K
- Lim S
- Lim Sj
- Linton A
- Liu C
- Liu S
- Livesey A
- Lo Secco G
- Lo T
- Lockey Jw
- Logan Ae
- Loke W
- Long F
- Long K
- Longstaff L
- Loo J
- Looijen Rc
- Lopes S
- Lopez Garcia Mc
- Lopez G
- Lotfallah A
- Lou Cn
- Loughran D
- Loveday J
- Low Jyl
- Lowe R
- Lu Q
- Lua Boon Xuan J
- Lucas de Carvalho J
- Luehrman A
- Luhishi A
- Lujan Mompean Ja
- Luk Cy
- Lunawat S
- Lwin Kn
- Lykoudis Pm
- Lynch As
- Lynne S
- Lyons A
- Lyons R
- López-Mármol R
- López-Vendrell L
- Löwensteyn Yn
- Maamari R
- Maan Ds
- Macaskill A
- Macdonald A
- Macdonald J
- Machačová A
- Mackin S
- Maclennan D
- Magnoli M
- Mah J
- Mahboob S
- Mahesh S
- Maheswaran Y
- Mahmood J
- Majid S
- Major C
- Malaj M
- Malak M
- Malik A
- Mallick S
- Malys Mk
- Manson R
- Mansoor S
- Manvydas V
- Maple N
- Marchal St
- Marchese N
- Marcos Rodrigo A
- Mariani F
- Markham Rm
- Marsden M
- Marsh A
- Marsh L
- Marshall Dc
- Marti Gelonch L
- Martin Morales E
- Martin Al
- Martin R
- Martinez Diaz Jm
- Martinez Rios Ce
- Martorana M
- Martí Fernández Rm
- Martínez Chillarón E
- Maru D
- Mason Jd
- Masood M
- Mastan A
- Mastandrea Bonaviri Gn
- Mate-Mate P
- Matheson J
- Matthams J
- Matthews Bw
- Matthews Jh
- Mauro D
- Maxwell-Armstrong C
- Mayes Jw
- Mazan K
- Mazumdar E
- Mcaleer E
- Mcaleer S
- Mcallister R
- Mcauley D
- Mcbride A
- Mccabe G
- Mccance E
- Mccann M
- Mcclymont Lf
- Mccormack Dr
- Mccrann C
- Mcdowell M
- Mcenhill Pm
- Mcfarlane H
- Mcgalliard Rj
- Mcgarrigle C
- Mcgarvie S
- Mcgenity C
- Mcgowan C
- Mcgrath A
- Mcgregor Rj
- Mcintyre Cj
- Mckean E
- Mckelvey Ll
- Mckerr Cn
- Mckevitt Kl
- Mclaughin C
- Mclean Rc
- Mclure Sw
- Mcmenamin M
- Mcmullan R
- Mcnamee L
- Mcrobbie Hd
- Medina-Fernández Fj
- Meek J
- Mehdi A
- Mehta Jk
- Meijerink Wjhj
- Menduni N
- Menon A
- Mensink G
- Mericliler M
- Mermer S
- Messina F
- Mestres Petit N
- Metcalf P
- Mian A
- Milana F
- Milazzo Lf
- Millan M
- Mills Ed
- Mills H
- Mills M
- Milne S
- Minhas M
- Mirallas Viñas O
- Miranda Bh
- Mirdavoudi V
- Mirza M
- Mishra A
- Mistry Bd
- Mistry S
- Mitchell H
- Mitha N
- Mithrakumar P
- Mitrasinovic S
- Mittapalli D
- Mitxelena Elosegi L
- Mizan Sr
- Mogan Yp
- Mohamed Us
- Mohamud M
- Mohan K
- Mohan M
- Mohite A
- Momoh Z
- Montanelli P
- Montuori M
- Monzonis Hernandez X
- Moody N
- Moon Rdc
- Moradzadeh J
- Moran D
- Morandi V
- Moratilla Lapeña L
- Morgan C
- Morgan F
- Morino M
- Morley R
- Moroni P
- Morris F
- Morris S
- Morrison Cj
- Morrison P
- Mortimer A
- Morton D
- Mosterd Cm
- Mugurtay Ys
- Mulder Im
- Muller S
- Mural-Krishnan S
- Muriel P
- Murkin C
- Muro M
- Murphy L
- Murray Se
- Murtaza A
- Murtaza Mi
- Mushtaq J
- Mustafa S
- Musters Gd
- Mutlu B
- Mutlu D
- Myers L
- Naccari P
- Naccari Pm
- Nachiappan R
- Nadanakumaran K
- Naqib S
- Narain A
- Naran P
- Narang Y
- Narayan P
- Narramore R
- Narwani V
- Navayogaarajah V
- Naveed H
- Nayee H
- Neary A
- Nehikhare I
- Nelaj S
- Nelli T
- Neo Yn
- Neophytou C
- Nepogodiev D
- Nesargikar Pn
- Ng Ayl
- Ng Gs
- Ng Jck
- Ng Jq
- Ng K
- Ng L
- Ng S
- Ngaage M
- Nicholls K
- Nixon G
- Noone Tm
- Norris Jm
- North As
- Norton J
- Nota Clma
- Notarnicola M
- Ntala C
- O'Bryan M
- O'Byrne L
- O'Carroll O
- O'Connell C
- O'Connor A
- O'Connor S
- O'Dwyer M
- O'Flynn Ld
- O'Kane A
- O'Loughlin Ra
- O'Neill Em
- O'Neill S
- O'Reilly D
- O'Sullivan Da
- O'Sullivan H
- O'Sullivan K
- Oakley T
- Obute Rd
- Odeleye A
- Ogunleye O
- Olivier J
- Omar A
- Omara S
- Omer Hm
- Onar D
- Oncel M
- Ong Kk
- Onsal U
- Oostendorp Se
- Oremule B
- Orhalmi J
- Orhan K
- Osei-Kuffour D
- Osman S
- Oudman Ts
- Oun H
- Owasil R
- Owczarek S
- Ozbalci Gs
- Ozben V
- Ozgencil B
- Ozmen Bb
- Ozsipahi Ac
- Padilla Valverde D
- Paine Hr
- Pal S
- Palanivail N
- Palkhi E
- Pallara E
- Palmer C
- Palmieri A
- Palmisano S
- Palos Campos Mc
- Palyzová H
- Pandey A
- Pandey G
- Pando Ruiz B
- Pang G
- Pantalone Mr
- Paolo G
- Papandrea M
- Papazachariou Sk
- Parajo A
- Paraoan V
- Parimli H
- Parinisi Z
- Park Jh
- Parker J
- Parker O
- Parkin J
- Parmar E
- Parsons S
- Parthiban S
- Pasquali S
- Pasqualoni M
- Pastor-Riquelme P
- Pata F
- Patel B
- Patel Ba
- Patel By
- Patel Jb
- Patel K
- Patel M
- Patel N
- Patel P
- Patel S
- Patel T
- Patel V
- Pattapola V
- Patturelli M
- Paul J
- Pearce J
- Pearse Rj
- Peck Fs
- Pehlivan M
- Peinado Iribar B
- Pektas Am
- Pellino G
- Perera M
- Perez Arias H
- Perez Costoya C
- Perez Febles M
- Perez Jl
- Perez-Gandara B
- Pericleous A
- Peroos S
- Perrotta G
- Persiani R
- Pesser N
- Peters M
- Petra H
- Petrarca M
- Petrov G
- Pezas Tp
- Pezzuto R
- Phan Pn
- Phillips C
- Picciariello A
- Pickard J
- Pietrabissa A
- Pike G
- Pineño-Flores C
- Pinkney Td
- Pinto R
- Piquet A
- Piraliyev E
- Piran G
- Pistola I
- Pitts-Tucker T
- Pizzolato A
- Pla Seró S
- Player C
- Plomer-Sanchez M
- Poacher A
- Poelman M
- Polat F
- Polat Zp
- Ponweera A
- Poo Sx
- Pope S
- Portugal Porras V
- Posada M
- Posteki G
- Poyato Nuñez Fj
- Prabhudesai A
- Prado Perez R
- Prakash E
- Preece R
- Prest-Smith J
- Priani P
- Priestland R
- Prieto-Nieto Mi
- Pronk A
- Protti Ruiz Gp
- Prys-Jones O
- Ptacek Ib
- Puan L
- Puccioni C
- Pujol-Cano N
- Pulpito S
- Punj R
- Punjabi N
- Pös M
- Qamar Ma
- Quill S
- Quinn K
- Qureshi A
- Qureshi S
- Qureshi U
- Rabinthiran S
- Radotra A
- Rafiq Nm
- Raghuvir V
- Raghvani T
- Rahmee Cns
- Raimondi P
- Raina V
- Rajan N
- Raji K
- Rakhimov I
- Raman Kp
- Ramana A
- Ramjeeawon N
- Ramnarine A
- Rampal R
- Rampulla V
- Ramsay N
- Ramtoola T
- Randisi B
- Rangan T
- Rangedara A
- Raphael M
- Rashid M
- Rashid S
- Rasiah Mg
- Ratnakumaran R
- Rattan G
- Ratu Sg
- Raurich-Leandro J
- Raut P
- Reakes T
- Realis Luc A
- Redgrave Na
- Redmond A
- Reed A
- Reeder C
- Reehal Rs
- Rees C
- Rees S
- Reeves T
- Reggiani L
- Reid Kg
- Reid Nb
- Reid R
- Rejayee M
- Remedios J
- Remore Lm
- Reynolds J
- Rhema Ia
- Ribbink Me
- Ridgway P
- Rinkoff S
- Ripa M
- Riva L
- Riva M
- Rizzi A
- Rob T
- Roberts Aw
- Roberts C
- Roberts Ej
- Roberts Hf
- Robertson Dt
- Robertson Kl
- Robertson V
- Robinson C
- Robinson M
- Robson J
- Rocco I
- Roche D
- Rocke As
- Rodrigues Silva K
- Rodriguez Garcia R
- Rogers Je
- Rogers S
- Rojoa D
- Romano F
- Romeo F
- Romero-Simó M
- Rookes Cw
- Roquet Puigneró E
- Rosati G
- Rosati R
- Rosen O'Sullivan H
- Ross H
- Ross T
- Rossi E
- Rothwell L
- Roura J
- Roy Csd
- Rubbini M
- Rubio-Perez I
- Ruiz Montesinos I
- Ruiz Em
- Russell G
- Ryan M
- Saat Mi
- Sabine Lm
- Sacco R
- Sagar R
- Saglam Za
- Sagmeister M
- Sahathevan A
- Sahin A
- Sait Ms
- Sajjad U
- Sakman G
- Salam Gj
- Salamone G
- Salazar-García C
- Sale T
- Salem M
- Salih Ae
- Salman M
- Salmon D
- Sam Zh
- Sammarco G
- Sampietro G
- San Martín Bragado M
- Sanchez Cambronero M
- Sanchez A
- Sanchez-Guillen L
- Sanders Ja
- Sandhu Kk
- Sandhu S
- Sandison L
- Sangal P
- Santocchi P
- Sanz Ortega G
- Sapci I
- Saraceno F
- Sari V
- Sartori A
- Sarvanandan T
- Sarwar S
- Sasapu K
- Satterthwaite L
- Schasfoort Ra
- Schiphorst A
- Schizas A
- Schmidt Pa
- Schofield E
- Schok T
- Schulz Tm
- Schulzová M
- Scotcher Se
- Seager E
- Sebaoui S
- Secilmis E
- Sedee Wja
- Seedat M
- Segall E
- Segura-Sampedro Jj
- Sellathurai J
- Selvachandran H
- Selvaggi F
- Selvaggi L
- Semana Ad
- Semiz A
- Semnani Sa
- Semple E
- Sen Ay
- Sena-Ruiz F
- Senay Bb
- Seneviratne N
- Sengul N
- Sensi B
- Senturk E
- Sethi Rk
- Sette M
- Seyhan U
- Seyrek N
- Sgroi G
- Sgrò A
- Shafi Ama
- Shafiq Nm
- Shah A
- Shah Jp
- Shah R
- Shah S
- Shaheen H
- Shahid S
- Shahidi S
- Shakweh E
- Shamsul Badrin Ak
- Shanahan D
- Sharifpour M
- Sharma Khatiwada A
- Shatkar V
- Shaunak R
- Sheikh Imi
- Sheldon A
- Shepherd P
- Shepherd R
- Sherif Ma
- Sherliker Gxj
- Sheth S
- Shoa M
- Shufflebotham H
- Shuker Ba
- Shukla A
- Shumon S
- Shurovi B
- Shurovi Bn
- Shuttleworth Rh
- Sica G
- Siddiqui M
- Siddiqui Zh
- Sii S
- Sim D
- Sim Nk
- Sim P
- Simioni A
- Simon Frapolli V
- Simpson A
- Simpson R
- Singagireson S
- Singh B
- Singh K
- Singh R
- Singh S
- Sinha A
- Sinha Y
- Sirakaya M
- Sitta O
- Sivrikaya T
- Skalamera I
- Slade R
- Slieker Fjb
- Smart Nj
- Smeets Hj
- Smet M
- Smith Acd
- Smith Ag
- Smith Dne
- Smith N
- Smolák P
- Sng S
- Soldevila-Verdeguer C
- Soo Yh
- Soon Wc
- Sorah T
- Soria Aledo V
- Sotona O
- Soylemez Zobb
- Sozuer Em
- Spence O
- Spencer T
- Spijkerman R
- Springford Lr
- Sproule L
- Sreh A
- Srikantharajah M
- Sritharan P
- Staderini F
- Stanger Sa
- Stanley Gh
- Stanley S
- Stassen Lps
- Stather Pw
- Steccanella F
- Stechman M
- Steel M
- Stein J
- Stellingwerf Me
- Steup Wh
- Stevens S
- Stewart Ge
- Stezaker S
- Stijns Rch
- Stoddart Mt
- Stokes S
- Stone Ej
- Stott Gd
- Strange E
- Street An
- Subasi A
- Sukkari M
- Sukumar S
- Suleman Yn
- Sullivan Jal
- Sun E
- Sundar-Singh M
- Suppa A
- Suresh Rs
- Suresh S
- Syeed Ja
- Sykes Mc
- Szczap A
- Sánchez Estébanez E
- Sánchez-Blasco L
- Tagariello F
- Tahir M
- Tahmina A
- Tai A
- Talukdar Ss
- Tan D
- Tan Esm
- Tan Et
- Tan R
- Tan S
- Tan Y
- Tan Yh
- Tansoker I
- Tarantino M
- Targa S
- Taskin O
- Taskin Rb
- Tavuz Ai
- Tay Ay
- Tayeh S
- Taylor F
- Taşçı Y
- Tear Ak
- Teh Jw
- Teixeira da Silva M
- Tejero Pintor Fj
- Telfer R
- Temiz C
- Teng V
- Teoh Pj
- Ter Bruggen Ffja
- Ter Horst L
- Ter Weele K
- Thacoor A
- Thakker Ce
- Thakur H
- Tharakan Rg
- Tharmachandirar T
- Theodoreson Md
- Theodoropoulou K
- Thethi R
- Thevathasan Aa
- Thirumal V
- Thomas D
- Thomas G
- Thomas-Davies M
- Thompson Jd
- Thompson Od
- Tiedt L
- Tilston Tw
- Tippins F
- Tirnaksiz Mb
- Toale C
- Tognolo L
- Toh C
- Tomas K
- Toner E
- Tongo F
- Tonkins M
- Toorenvliet Br
- Topal U
- Topalan K
- Topham C
- Torlot Ge
- Torrance Hd
- Tosun V
- Toto Of
- Trail M
- Traynor Bp
- Trecarten S
- Trimble A
- Trist Aj
- Troia A
- Trompetto M
- Truma A
- Truss A
- Tsui Ay
- Tulum H
- Tung L
- Turaga S
- Turati L
- Turkmen M
- Turley H
- Turnbull Ja
- Turner Ejh
- Turner J
- Turner L
- Turner M
- Turpan M
- Tutam Dn
- Ucar E
- Uctepe F
- Uittenbogaart M
- Ulkucu A
- Ulusahin M
- Unal Ag
- Ungcharoen N
- Uppal E
- Urquhart A
- Uzun B
- Uzun O
- Uzun S
- Uzunoglu Ec
- Vable T
- Valderrama Pérez A
- Valli A
- Vallve-Bernal M
- Van Bruggen D
- van Dalen Ashm
- van de Ven Awh
- van der Harst E
- van der Hoeven Ac
- Van der Lubbe M
- van der Pool Aem
- van der Zee C
- Van Dijck Wpm
- van Elst Tr
- van Engelenburg T
- van Geloven A
- Van Grevenstein Wmu
- Van Heumen Tm
- van Leeuwen Bl
- van Rijckevorsel Vajim
- van Steensel L
- Van Tol Rr
- van Verschuer Vmt
- van Wijnbergen Jwm
- Vanmali P
- Varley R
- Varma D
- Varma N
- Varma Rk
- Varo Muñoz A
- Vasko P
- Vasquez G
- Vaughan R
- Vazquez-Gonzalez I
- Veenker Cgh
- Vela Polanco Ff
- Vendramin E
- Venn M
- Ventre Cm
- Venturini S
- Verardi L
- Verboeket B
- Verma K
- Verma S
- Vermaas M
- Vernon Ok
- Villarejo Campos P
- Vinci A
- Vithanage Na
- Vivekanantham S
- Vives-Rodriguez E
- Viñas-Salas J
- Vries Jjm
- Wadanamby S
- Waldron Rm
- Walford Ra
- Wali A
- Wall C
- Walsh Sl
- Wan Jc
- Wang A
- Wang S
- Ward Ae
- Ward N
- Ward T
- Warren N
- Warwick Hl
- Watson N
- Watson Rp
- Weaver R
- Webb E
- Weinberg D
- Wells M
- Weston C
- Wetherall N
- Whacha C
- Whatling Ea
- Whewell H
- White A
- White Cj
- White U
- Whitehurst K
- Whitham Rdj
- Whittingham H
- Wiersema R
- Wiezer R
- Wijesekera M
- Wijffels N
- Wijnhoven Bpl
- Wild Jrl
- Wilkinson D
- Willems L
- Willems Yr
- Williams M
- Williams Mr
- Williams P
- Williams Rp
- Wills J
- Wilson H
- Wilson Hcp
- Wilson R
- Wilson T
- Wiltshire Jj
- Winarski A
- Wing Vc
- Wingfield Lr
- Winslow F
- Woin E
- Wong C
- Wong E
- Wong V
- Wood Ad
- Woodcock N
- Woodward H
- Woon E
- Wright A
- Wright Ev
- Wye J
- Wylam D
- Wylie J
- Wynell-Mayow Wm
- Xiao C
- Xu Gx
- Xylas D
- Yalcin Y
- Yaman S
- Yan A
- Yang T
- Yasar C
- Yates Ja
- Yauw S
- Yavuz G
- Yazkan Z
- Yekenkurul E
- Yener A
- Yeoh Tsl
- Yetiskin E
- Yıgman S
- Yildirim N
- Yildirim R
- Yildiz S
- Yildiz Ss
- Yildiz T
- Yilmaz I
- Yilmaz M
- Yilmaz S
- Yilmaz T
- Yim N
- Yoganathan S
- Yong Cs
- Yong N
- Yoruk I
- Yousif A
- Yow L
- Yuen R
- Yuksek B
- Yuksek Ma
- Yuksel A
- Yurdaor Ss
- Yurekli Am
- Zaidi R
- Zegeye Mi
- Zengin T
- Zhang Aa
- Zhao J
- Ziff O
- Zigiotto D
- Zijlmans Jl
- Zimmerman D
- Ziprin P
- Zope S
- Zuhair M
- Örhalmi J
- Özkan Bb
- Šimáčková B
- Široká M
- Žebrák R
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien\u2013Dindo Grades III\u2013V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49\u20132.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46\u20130.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease