8,757 research outputs found
Exceptional Outgroup Stereotypes and White Racial Inequality Attitudes toward Asian Americans
Stereotypes of outgroups help create social identificational boundaries for ingroups. When the ingroup is dominant, members employ individualist sentiments to justify their status. In this study, we build on advances in social psychological research that account for multiple outgroup stereotypes. We argue the Asian American model minority stereotype is analogous to the âcold but competentâ position of perceptions toward Asians in Fiskeâs stereotype content model. Asian Americans are perceived to be exceptional to other minority groups, and we hypothesize that perceived competence is associated with individualist sentiments directed at Blacks and Latinos. Using data from the National Longitudinal Study of Freshmen, we find support for our hypotheses but find that perceived coldness has no relationship to individualist sentiments. We discuss the implications and directions for further research
Relevance of Fc Gamma Receptor Polymorphisms in Cancer Therapy With Monoclonal Antibodies
Therapeutic monoclonal antibodies (mAbs), including immune checkpoint inhibitors (ICIs), are an important breakthrough for the treatment of cancer and have dramatically changed clinical outcomes in a wide variety of tumours. However, clinical response varies among patients receiving mAb-based treatment, so it is necessary to search for predictive biomarkers of response to identify the patients who will derive the greatest therapeutic benefit. The interaction of mAbs with Fc gamma receptors (Fc gamma R) expressed by innate immune cells is essential for antibody-dependent cellular cytotoxicity (ADCC) and this binding is often critical for their in vivo efficacy. Fc gamma RIIa (H131R) and Fc gamma RIIIa (V158F) polymorphisms have been reported to correlate with response to therapeutic mAbs. These polymorphisms play a major role in the affinity of mAb receptors and, therefore, can exert a profound impact on antitumor response in these therapies. Furthermore, recent reports have revealed potential mechanisms of ICIs to modulate myeloid subset composition within the tumour microenvironment through Fc gamma R-binding, optimizing their anti-tumour activity. The purpose of this review is to highlight the clinical contribution of Fc gamma R polymorphisms to predict response to mAbs in cancer patients
Cost-Utility Analysis of a Medication Review with Follow-Up Service for Older Adults with Polypharmacy in Community Pharmacies in Spain: The conSIGUE Program
© 2015, Springer International Publishing Switzerland. Background: The concept of pharmaceutical care is operationalized through pharmaceutical professional services, which are patient-oriented to optimize their pharmacotherapy and to improve clinical outcomes. Objective: The objective of this study was to estimate the incremental cost-effectiveness ratio (ICER) of a medication review with follow-up (MRF) service for older adults with polypharmacy in Spanish community pharmacies against the alternative of having their medication dispensed normally. Methods: The study was designed as a cluster randomized controlled trial, and was carried out over a time horizon of 6 months. The target population was older adults with polypharmacy, defined as individuals taking five or more medicines per day. The study was conducted in 178 community pharmacies in Spain. Cost-utility analysis adopted a health service perspective. Costs were in euros at 2014 prices and the effectiveness of the intervention was estimated as quality-adjusted life-years (QALYs). In order to analyze the uncertainty of ICER results, we performed a non-parametric bootstrapping with 5000 replications. Results: A total of 1403 older adults, aged between 65 and 94 years, were enrolled in the study: 688 in the intervention group (IG) and 715 in the control group (CG). By the end of the follow-up, both groups had reduced the mean number of prescribed medications they took, although this reduction was greater in the IG (0.28 ± 1.25 drugs; p < 0.001) than in the CG (0.07 ± 0.95 drugs; p = 0.063). Older adults in the IG saw their quality of life improved by 0.0528 ± 0.20 (p < 0.001). In contrast, the CG experienced a slight reduction in their quality of life: 0.0022 ± 0.24 (p = 0.815). The mean total cost was âŹ977.57 ± 1455.88 for the IG and âŹ1173.44 ± 3671.65 for the CG. In order to estimate the ICER, we used the costs adjusted for baseline medications and QALYs adjusted for baseline utility score, resulting in a mean incremental total cost of ââŹ250.51 ± 148.61 (95 % CI â541.79 to 40.76) and a mean incremental QALY of 0.0156 ± 0.004 (95 % CI 0.008â0.023). Regarding the results from the cost-utility analysis, the MRF service emerged as the dominant strategy. Conclusion: The MRF service is an effective intervention for optimizing prescribed medication and improving quality of life in older adults with polypharmacy in community pharmacies. The results from the cost-utility analysis suggest that the MRF service is cost effective
On the dynamics of WKB wave functions whose phase are weak KAM solutions of H-J equation
In the framework of toroidal Pseudodifferential operators on the flat torus
we begin by proving the closure under
composition for the class of Weyl operators with
simbols . Subsequently, we
consider when where and we exhibit the toroidal version of the
equation for the Wigner transform of the solution of the Schr\"odinger
equation. Moreover, we prove the convergence (in a weak sense) of the Wigner
transform of the solution of the Schr\"odinger equation to the solution of the
Liouville equation on written in the measure sense.
These results are applied to the study of some WKB type wave functions in the
Sobolev space with phase functions in the class
of Lipschitz continuous weak KAM solutions (of positive and negative type) of
the Hamilton-Jacobi equation for with , and to the study of the
backward and forward time propagation of the related Wigner measures supported
on the graph of
Drag force in a strongly coupled anisotropic plasma
We calculate the drag force experienced by an infinitely massive quark
propagating at constant velocity through an anisotropic, strongly coupled N=4
plasma by means of its gravity dual. We find that the gluon cloud trailing
behind the quark is generally misaligned with the quark velocity, and that the
latter is also misaligned with the force. The drag coefficient can be
larger or smaller than the corresponding isotropic value depending on the
velocity and the direction of motion. In the ultra-relativistic limit we find
that generically . We discuss the conditions under which this
behaviour may extend to more general situations.Comment: 25 pages, 13 figures; v2: minor changes, added reference
DNA-based population density estimation of black bear at northern Mexico: A preliminary study
The analysis of deoxyribonucleic acid (DNA) microsatellites from hair samples obtained by the non-invasive method of traps was used to estimate the population density of black bears (Ursus americanus eremicus) in a mountain located at the county of Lampazos, Nuevo Leon, Mexico. The genotyping of bears was performed by multiplex polymerase chain reaction (PCR) using an average of two hairs for each animal. Samples were obtained with barbed wire placed at the traps, which contained food as bait. Multiplex PCR was performed with the GenomiPhiTM, G.E. kit and genotyping with an automated DNA sequencing machine (ABI 310 System). Allelic frequency, heterozygosis and exclusion probability of seven DNA microsatellites were calculated and analyzed with computer programs to determine the population density. Three of the microsatellites had a heterozygosis higher than 0.7 and the population density was calculated in at least 1 bear/km2.Keywords: Black bear, Ursus americanus, population size, DNA microsatellite, MexicoAfrican Journal of Biotechnology Vol. 12(2), pp. 103-10
The , , and mesons in a double pole QCD Sum Rule
We use the method of double pole QCD sum rule which is basically a fit with
two exponentials of the correlation function, where we can extract the masses
and decay constants of mesons as a function of the Borel mass. We apply this
method to study the mesons: , , and
. We also present predictions for the toponiuns masses
of m(1S)=357 GeV and m(2S)=374 GeV.Comment: 14 pages, 11 figures in Braz J Phys (2016
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