350 research outputs found
Minimal length in quantum space and integrations of the line element in Noncommutative Geometry
We question the emergence of a minimal length in quantum spacetime, comparing
two notions that appeared at various points in the literature: on the one side,
the quantum length as the spectrum of an operator L in the Doplicher
Fredenhagen Roberts (DFR) quantum spacetime, as well as in the canonical
noncommutative spacetime; on the other side, Connes' spectral distance in
noncommutative geometry. Although on the Euclidean space the two notions merge
into the one of geodesic distance, they yield distinct results in the
noncommutative framework. In particular on the Moyal plane, the quantum length
is bounded above from zero while the spectral distance can take any real
positive value, including infinity. We show how to solve this discrepancy by
doubling the spectral triple. This leads us to introduce a modified quantum
length d'_L, which coincides exactly with the spectral distance d_D on the set
of states of optimal localization. On the set of eigenstates of the quantum
harmonic oscillator - together with their translations - d'_L and d_D coincide
asymptotically, both in the high energy and large translation limits. At small
energy, we interpret the discrepancy between d'_L and d_D as two distinct ways
of integrating the line element on a quantum space. This leads us to propose an
equation for a geodesic on the Moyal plane.Comment: 29 pages, 2 figures. Minor corrections to match the published versio
Diamonds's Temperature: Unruh effect for bounded trajectories and thermal time hypothesis
We study the Unruh effect for an observer with a finite lifetime, using the
thermal time hypothesis. The thermal time hypothesis maintains that: (i) time
is the physical quantity determined by the flow defined by a state over an
observable algebra, and (ii) when this flow is proportional to a geometric flow
in spacetime, temperature is the ratio between flow parameter and proper time.
An eternal accelerated Unruh observer has access to the local algebra
associated to a Rindler wedge. The flow defined by the Minkowski vacuum of a
field theory over this algebra is proportional to a flow in spacetime and the
associated temperature is the Unruh temperature. An observer with a finite
lifetime has access to the local observable algebra associated to a finite
spacetime region called a "diamond". The flow defined by the Minkowski vacuum
of a (four dimensional, conformally invariant) quantum field theory over this
algebra is also proportional to a flow in spacetime. The associated temperature
generalizes the Unruh temperature to finite lifetime observers.
Furthermore, this temperature does not vanish even in the limit in which the
acceleration is zero. The temperature associated to an inertial observer with
lifetime T, which we denote as "diamond's temperature", is 2hbar/(pi k_b
T).This temperature is related to the fact that a finite lifetime observer does
not have access to all the degrees of freedom of the quantum field theory.Comment: One reference correcte
Neurologic complications of acute hepatitis E virus infection.
To assess the prevalence and clinical features of neurologic involvement in patients with acute hepatitis E virus (HEV) infection in Southern Switzerland.
Among 1,940 consecutive patients investigated for acute hepatitis E, we identified 141 cases of acute of HEV infection (anti-HEV immunoglobulin M and immunoglobulin G both reactive and/or HEV RNA positive) between June 2014 and September 2017. Neurologic cases were followed up for 6 months. We compared patients with and without neurologic symptoms.
Neurologic symptoms occurred in 43 acute HEV cases (30.4%) and consisted of neuralgic amyotrophy (NA, n = 15, 10.6%) and myalgia (n = 28, 19.8%). All NA cases were immunocompetent. Men had higher odds (OR = 5.2, CI 1.12-24.0, p = 0.03) of developing NA after infection with HEV, and in 3 couples simultaneously infected with HEV, only men developed NA. Bilateral involvement of NA was predominant (2:1) and occurred only in men. Seven NA cases were viremic (all genotype 3), but HEV was undetectable in their CSF. In the acute phase of NA, 9 patients were treated with intravenous immunoglobulin and 4 with prednisone, reporting no side effects and improvement in pain and strength. Myalgia occurred both without (n = 16) or with (n = 12) concomitant elevated serum creatinine kinase. Seven cases with myalgia in the shoulder girdle did not have muscle weakness ("forme fruste" of NA).
Neurologic symptoms occurred in one-third of acute HEV infections and consisted of NA and myalgia. NA seems to occur more frequently in men infected by HEV and has a predominant (but not exclusive) bilateral involvement
Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity.
none15We analyzed 21 children with leukemia receiving haploidentical hematopoietic stem cell transplantation (haplo-HSCT) from killer immunoglobulin (Ig)-like receptors (KIR) ligand-mismatched donors. We showed that, in most transplantation patients, variable proportions of donor-derived alloreactive natural killer (NK) cells displaying anti-leukemia activity were generated and maintained even late after transplantation. This was assessed through analysis of donor KIR genotype, as well as through phenotypic and functional analyses of NK cells, both at the polyclonal and clonal level. Donor-derived KIR2DL1(+) NK cells isolated from the recipient displayed the expected capability of selectively killing C1/C1 target cells, including patient leukemia blasts. Differently, KIR2DL2/3(+) NK cells displayed poor alloreactivity against leukemia cells carrying human leukocyte antigen (HLA) alleles belonging to C2 group. Unexpectedly, this was due to recognition of C2 by KIR2DL2/3, as revealed by receptor blocking experiments and by binding assays of soluble KIR to HLA-C transfectants. Remarkably, however, C2/C2 leukemia blasts were killed by KIR2DL2/3(+) (or by NKG2A(+)) NK cells that coexpressed KIR2DS1. This could be explained by the ability of KIR2DS1 to directly recognize C2 on leukemia cells. A role of the KIR2DS2 activating receptor in leukemia cell lysis could not be demonstrated. Altogether, these results may have important clinical implications for the selection of optimal donors for haplo-HSCT.openPENDE D; MARCENARO S; FALCO M; MARTINI S; BERNARDO ME; MONTAGNA D; ROMEO E; COGNET C; MARTINETTI M; MACCARIO R; MINGARI MC; VIVIER E; MORETTA L; LOCATELLI F; MORETTA A.Pende, D; Marcenaro, S; Falco, M; Martini, S; Bernardo, Me; Montagna, Daniela; Romeo, E; Cognet, C; Martinetti, M; Maccario, R; Mingari, Mc; Vivier, E; Moretta, L; Locatelli, Franco; Moretta, A
Conceptual Unification of Gravity and Quanta
We present a model unifying general relativity and quantum mechanics. The
model is based on the (noncommutative) algebra \mbox{{\cal A}} on the groupoid
\Gamma = E \times G where E is the total space of the frame bundle over
spacetime, and G the Lorentz group. The differential geometry, based on
derivations of \mbox{{\cal A}}, is constructed. The eigenvalue equation for the
Einstein operator plays the role of the generalized Einstein's equation. The
algebra \mbox{{\cal A}}, when suitably represented in a bundle of Hilbert
spaces, is a von Neumann algebra \mathcal{M} of random operators representing
the quantum sector of the model. The Tomita-Takesaki theorem allows us to
define the dynamics of random operators which depends on the state \phi . The
same state defines the noncommutative probability measure (in the sense of
Voiculescu's free probability theory). Moreover, the state \phi satisfies the
Kubo-Martin-Schwinger (KMS) condition, and can be interpreted as describing a
generalized equilibrium state. By suitably averaging elements of the algebra
\mbox{{\cal A}}, one recovers the standard geometry of spacetime. We show that
any act of measurement, performed at a given spacetime point, makes the model
to collapse to the standard quantum mechanics (on the group G). As an example
we compute the noncommutative version of the closed Friedman world model.
Generalized eigenvalues of the Einstein operator produce the correct components
of the energy-momentum tensor. Dynamics of random operators does not ``feel''
singularities.Comment: 28 LaTex pages. Substantially enlarged version. Improved definition
of generalized Einstein's field equation
Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population
BACKGROUND: Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity is achieved through differences in gene content and allelic polymorphism. The number of KIR loci has been reported to vary among individuals, resulting in different KIR haplotypes. In this study we report the genotypic structure of KIRs in 217 unrelated healthy Italian individuals from 22 immunogenetics laboratories, located in the northern, central and southern regions of Italy. METHODS: Two hundred and seventeen DNA samples were studied by a low resolution PCR-SSP kit designed to identify all KIR genes. RESULTS: All 17 KIR genes were observed in the population with different frequencies than other Caucasian and non-Caucasian populations; framework genes KIR3DL3, KIR3DP1, KIR2DL4 and KIR3DL2 were present in all individuals. Sixty-five different profiles were found in this Italian population study. Haplotype A remains the most prevalent and genotype 1, with a frequency of 28.5%, is the most commonly observed in the Italian population. CONCLUSION: The Italian Caucasian population shows polymorphism of the KIR gene family like other Caucasian and non-Caucasian populations. Although 64 genotypes have been observed, genotype 1 remains the most frequent as already observed in other populations. Such knowledge of the KIR gene distribution in populations is very useful in the study of associations with diseases and in selection of donors for haploidentical bone marrow transplantation
Expected performance of the ASTRI-SST-2M telescope prototype
ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) is an
Italian flagship project pursued by INAF (Istituto Nazionale di Astrofisica)
strictly linked to the development of the Cherenkov Telescope Array, CTA.
Primary goal of the ASTRI program is the design and production of an end-to-end
prototype of a Small Size Telescope for the CTA sub-array devoted to the
highest gamma-ray energy region. The prototype, named ASTRI SST-2M, will be
tested on field in Italy during 2014. This telescope will be the first
Cherenkov telescope adopting the double reflection layout in a
Schwarzschild-Couder configuration with a tessellated primary mirror and a
monolithic secondary mirror. The collected light will be focused on a compact
and light-weight camera based on silicon photo-multipliers covering a 9.6 deg
full field of view. Detailed Monte Carlo simulations have been performed to
estimate the performance of the planned telescope. The results regarding its
energy threshold, sensitivity and angular resolution are shown and discussed.Comment: In Proceedings of the 33rd International Cosmic Ray Conference
(ICRC2013), Rio de Janeiro (Brazil). All CTA contributions at arXiv:1307.223
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