The True North Arena: Downtown Revitalization and Decision-Making in Winnipeg

Online resource: 15 pp.; digital file.In 2001, Winnipeg’s City Council approved the demolition of the 96 year-old Eaton’s building to make way for a new sports arena in the heart of the city’s downtown. In spite of a growing body of research showing that sports facilities do not act as generators of economic activity in failing downtown centres, the project was touted as a catalyst for downtown revitalization. A group of citizens organized to stop the arena deal, and instead put forth an alternate, mixed-use proposal for the Eaton’s site known as Eaton Square. This paper examines both the Eaton Square and True North arena concepts in light of the City of Winnipeg’s own long-term policy goals, as well as findings in the scholarly literature, in order to evaluate which of these proposals would have been more likely to have a beneficial and rejuvenating effect on the downtown. The paper concludes that Winnipeg had little to gain by building the arena downtown, and in light of this finding, asks why City Council would have chosen to make what appears to be the wrong decision. Two trends in the city’s political history offer a clue: Historically, Winnipeg decision-makers have been dominated by a corporate elite, and citizen involvement in the political processes concerning controversial development projects (such as the True North Arena) has often been suppressed

New Deal Ruins: Race Economic Justice, and Public Housing Policy

Book review by Martine August of New Deal Ruins: Race Economic Justice, and Public Housing Policy written by Edward Goetz

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene coding for the IL-23 receptor and spondyloarthritis. This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with disease activity parameters. Methods Paired synovial fluid (SF), serum and synovial biopsies were obtained from 30 non-PsA (psoriatic arthritis) spondyloarthritis, 22 PsA and 22 rheumatoid arthritis (RA) patients. IL-17, IL-23 and CCL20 were measured by ELISA in the SF and serum of patients and correlated with systemic and local parameters of disease activity. Results Concentrations of CCL20, a major Th17-attracting chemokine, tended to be higher in the joints of RA than in spondyloarthritis patients. Interestingly, levels of CCL20 were markedly higher in SF as opposed to serum. In addition, there was a remarkable association between the expression of the Th17 cytokine system and the presence of intimal lining layer hyperplasia in RA. Also in the serum, there was a tendency for higher IL-23 levels in RA, which correlated strongly with disease activity parameters. Conclusions Th17-related cytokines are expressed in joints of spondyloarthritis as well as RA patients. IL-23 levels, however, correlate with disease activity parameters in RA only. These results point towards a differential regulation of the Th17 cytokine system in spondyloarthritis compared with RA

Reimagining geographies of public finance

The study of public finance—the role of government in the economy—has faded in geography as attention to private finance has grown. Disrupting the tendency to fetishize private financial power, this article proposes an expanded conception of public finance that emphasizes its role in shaping geographies of inequality. We conceptualize the relationship between public and private finance as a dynamic interface characterized today by asymmetrical power relations, path-dependent policy solutions, the depoliticization of markets, and uneven distributional effects. A reimagined theory and praxis of public finance can contribute to building abolitionist futures, and geographers are well positioned to advance this project

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Speculating Social Housing: Mixed-Iicome Public Housing Redevelopment in Toronto's Regent Park and Don Mount Court

This dissertation develops a multi-dimensional critique of the globally popular "socially mixed" public housing redevelopment approach, drawing on tenant experiences in Toronto's Regent Park and Don Mount Court communities. Socially mixed redevelopment involves the demolition of modernist public housing and its replacement with mixed-income, mixed-use communities; usually redesigned in a neo-traditional style and achieved via public-private partnership. This dissertation addresses three research questions and goals. First, it examines the impacts of redevelopment on tenants, who benefit from much-needed investment but endure hardship associated with relocation, gentrification, and displacement. Second, it critically examines core theoretical and planning ideas (`deconcentration' and `social mix') that serve to justify mixed-income redevelopment. These discourses rest on problematic core assumptions, and promote policies that - as I discover in a meta-analysis of nearly 200 empirical studies - do not deliver on their promises. Third, this research offers a political-economic critique of the significance and future impacts of redevelopment, placing tenant experiences in the context of local, state, and global economic restructuring. Redevelopment is presented as an example of what I call "speculative social welfare," a new and increasingly popular approach for financing former welfare state provisions in the context of global neoliberalism. Speculative social welfare replaces state expenditure with profits derived from gentrification and real estate speculation, relies on the market to allocate former welfare state provisions, entails reduced investment, and intensifies existing patterns of socio-spatial polarization. This research is based on qualitative methods, including in-depth interviews, ethnographic participant observation, and textual analysis. My analysis of redevelopment in Toronto reveals that financial motivations drive policy, trumping loftier planning, design, and equity-oriented goals. From pre-move tenant interviews, I develop a counter-narrative that challenges stigmatizing pro-revitalization rhetoric, and highlights `real' problems in Regent Park that redevelopment is ill-suited to address. Post-move interviews reveal that `old' problems are being reproduced in the mixed community, and highlight the negative political and social impacts of gentrification and displacement. My analysis of Don Mount Court points to the paradoxical outcomes of "New Urbanist" design, and challenges the `myth' of the benevolent middle class in a landscape marked by deeply uneven power relations.Ph.D.2018-06-13 00:00:0

Impact of thrice-weekly cotrimoxazole prophylaxis on creatinine and potassium plasma levels in kidney transplant recipients.

Cotrimoxazole (CTX) 800/160 mg daily or thrice-weekly is recommended as prophylaxis of Pneumocystis jirovecii pneumonia in kidney transplant recipients. Cotrimoxazole 800/160 daily elevates plasma creatinine and potassium levels but whether the thrice-weekly regimen does so is unknown. Medical records of 225 kidney transplant recipients at Cliniques Universitaires Saint-Luc were analyzed retrospectively. All received thrice-weekly CTX 800/160 for 6 months after transplantation. Monthly laboratory results, co-medications, and tacrolimus trough levels were compared. Standard statistical tests were used. One month after CTX stop, creatinine level decreased by 0.11 mg/dl (8%, p = 0.029). This contrasts with its stability in previous and subsequent months. No co-medication change accounted for this decrease. The decrease averaged 0.17 mg/dl (p < 0.01) in the highest initial creatinine tertile. The higher the initial creatinine level, the greater the decrease after CTX stop (p < 0.001), and urea levels remained stable after CTX stop. Potassium levels decreased by 0.09 mmol/L (p = 0.021) one month after CTX stop, and decreased by 0.23 mmol/L (p < 0.01) in the highest initial potassium level tertile. Our study pinpoints the impact of CTX 800/160 thrice-weekly on creatinine and potassium levels in kidney transplant recipients. This should be considered when interpreting the evolution of plasma creatinine over time, especially in patients with graft dysfunction. Thus, creatinine levels of cohorts with 6 months versus lifelong CTX require different interpretations

Varia

This issue of Lengas provides selected research papers related to Occitan, Catalan and minority languages. Aquel numèro de Lengas presenta divèrses articles de recèrca sus l'occitan, lo catalan e las lengas minoritàrias. Ce numéro de Lengas présente différents articles de recherche sur l'occitan, le catalan et les langues minoritaires