Le italiane e l’italiano: quattro studi su lingua e genere

Quattro studi su lingua e genere

Rehabilitation of Peripheral Neuropathies: From Lexical Analysis of the Literature to Identification of Clinical Protocols

Peripheral nervous system diseases are a complex and heterogenous group of diseases affecting the different nerves with various severity and impact on quality of life. The current literature does not provide a structured guide for the rehabilitation of these conditions. We performed a lexical literature evaluation based on graph theory to clarify this topic. We performed a search on PubMed and calculated the frequencies of the words indicating rehabilitation approaches, nerves, and diseases. We found the usefulness of exercises and different physical agents, like laser and ultrasound therapy and neuromuscular stimulation vibration therapy. Orthoses are useful for entrapment, trauma, and hereditary diseases. Correct knowledge and assessment of the neuropathies are fundamental for the therapeutic decision and to guide rehabilitation. Despite the usefulness shown by the different approaches to modulating pain, improving muscle strength and endurance, and ameliorating balance and the sensory system, further studies are needed to define the best-personalized protocols

Embracing change: nurturing equity, diversity, inclusivity and respect within the postgraduate community

Equity, diversity, inclusivity and respect (EDIR) are essential to the development of a welcoming, educational environment where all students can flourish. However, at the doctoral level there is a significant lack of formal EDIR training, which members of the postgraduate researcher (PGR) community find problematic. Inclusion of EDIR training at this level would be highly beneficial to the institution, students, staff and non-academic partners. Firstly, to train PGRs in the value and importance of EDIR would align with LJMU’s new vision and values. Student experience could be improved through the embracing and respecting of diversity and through the increased visibility and representation of under-represented and marginalised groups. Moreover, the introduction of EDIR training would contribute to research excellence with the view that current doctoral students are future academics and leaders. Therefore, instilling the importance of EDIR early in the academic journey will help in the development of responsible, global citizens. This is essential as it prepares our community to address societal problems, which is integral to achieving social sustainability. Demonstrably, EDIR should not be an afterthought. Instead, EDIR should be firmly embedded within the institutional culture to enable a non-judgemental platform for dialogue: a dialogue that involves individuals and communities in the decisions that impact them. Thus, work needs to be done to encourage societal change through advocating autonomy and enabling students to become active agents of change. To achieve this aim, a cross-faculty collaborative of students approached the doctoral academy with the ambition to improve EDIR practices. This has led to the co-creation of a new EDIR PGR workshop, which is in the preliminary stages of development. It is hoped that this workshop will be the beginning of a novel and exciting initiative that uses student voices to embrace change and shape our futures

Best methods and data to reconstruct paediatric lower limb bones for musculoskeletal modelling

In biomechanical simulations, generic linearly scaled musculoskeletal anatomies are commonly used to represent children, often neglecting or oversimplifying subject-specific features that may affect model estimates. Inappropriate bone sizing may influence joint angles due to erroneous joint centre identification. Alternatively, subject-specific image-based musculoskeletal models allow for more realistic representations of the skeletal system. To this end, statistical shape modelling (SSM) and morphing techniques may help to reconstruct bones rapidly and accurately. Specifically, the musculoskeletal atlas project (MAP) Client, which employs magnetic resonance imaging (MRI) and/or motion capture data to inform SSM and nonrigid morphing techniques, proved able to accurately reconstruct adult pelvis and femur bones. Nonetheless, to date, the above methods have never been applied to paediatric data. In this study, pelvis, femurs and tibiofibular bones of 18 typically developing children were reconstructed using the MAP Client. Ten different combinations of SSM and morphing techniques, i.e. pipelines, were developed. Generic bone geometries from the gait2392 OpenSim model were linearly scaled for comparisons. Jaccard index, root mean square distance error and Hausdorff distance were computed to quantify reconstruction accuracy. For the pelvis bone, colour maps were produced to identify areas prone to inaccuracies and hip joint centres (HJC) location was compared. Finally, per cent difference between MRI- and MAP-measured left-to-right HJC distances was computed. Pipelines informed by MRI data, alone or in combination with motion capture data, accurately reconstructed paediatric lower limb bones (i.e. Jaccard index > 0.8). Scaled OpenSim geometries provided the least accurate reconstructions. Principal component-based scaling methods produced size-dependent results, which were worse for smaller children.status: publishe

Safety profile of risankizumab in the treatment of psoriasis patients with concomitant hepatitis B or C infection: A multicentric retrospective cohort study of 49 patients

safety of risankizumab in patients with psoriasis and hepatitis B and

Ricordo di un maestro. Pietro Zerbi

Il volume raccoglie gli interventi presentati nel corso di una giornata di studio, svoltasi presso l'Università cattolica del Sacro Cuore a poco meno di un anno dalla morte del Professore, già preside della Facoltà di Lettere e Prorettore

Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients

Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS). We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1–IRF1, and C-X-C motif chemokine 10–CXCL10), belonging to the same pathway, was validated by RT-PCR in 26 patients and 21 controls. IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients. We confirmed this interaction and its functional effect by transfection experiments. Consistent findings indicate down-regulation of IRF1/CXCL10 axis, that may plausibly contribute to a pro-survival status of B cells in MS