In the Shadow of the Patriarch: the John J. Crittenden Family in War and Peace

An Examination of Crittenden and Family In the Shadow of the Patriarch chronicles the tale of the Crittendens, the Kentucky family prominent during the antebellum and Civil War eras. The patriarch in question, John J. Crittenden, enjoyed a long career in Kentucky politics, servi...

16S rRNA gene-based profiling of the human infant gut microbiota is strongly influenced by sample processing and PCR primer choice

Acknowledgements The authors acknowledge the assistance of Grietje Holtrop (RINH-BioSS) with the statistical analysis of the data and the Wellcome Trust Sanger Institute’s 454 pyrosequencing team for generating 16S rRNA gene data. AWW, PS and JP received core funding support from the Wellcome Trust [grant number 098051]. AWW, JCM, HJF and KPS are funded by the Scottish Government (SG-RESAS).Peer reviewedPublisher PD

Using self-categorization theory to uncover the framing of the 2015 Rugby World Cup: a cross-cultural comparison of three nations’ newspapers

Research into the framing of sporting events has been extensively studied to uncover newspaper bias in the coverage of global sporting events. Through discourse, the media attempt to capture, build, and maintain audiences for the duration of sporting events through the use of multiple narratives and/or storylines. Little research has looked at the ways in which the same event is reported across different nations, and media representations of the Rugby World Cup have rarely featured in discussions of the framing of sport events. The present study highlights the different ways in which rugby union is portrayed across the three leading Southern Hemisphere nations in the sport. It also shows the prominence of nationalistic discourse across those nations and importance of self-categorizations in newspaper narratives.</jats:p

Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation

The NF-kappa B/Rel family of at least five transcription factor polypeptides is thought to function both as a developmental regulator in B cells and as a rapid response system in all cells. To examine this notion in more detail, we determined the protein contents of both the inducible and constitutive NF-kappa B/Rel activities in a pre-B-cell line, 70Z/3, and a mature B-cell line, WEHI 231. NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells. The constitutive and inducible complexes in WEHI 231 cells are mainly composed of p50 and Rel. The constitutive or induced activities are all sensitive to I kappa B-alpha, but this inhibitor is very short-lived in WEHI 231 cells, suggesting that the balance between synthesis and degradation of I kappa B-alpha determines whether a particular cell lineage has constitutive activity. A patterned expression of the NF-kappa B/Rel activator proteins emerges from an analysis of other B-lineage cell lines and splenic B cells: mainly p50 and p65 in pre-B (and non-B) cells, a predominance of Rel and p50 in mature B cells, and expression of p52 and RelB in plasmacytoma lines. This ordered pattern of regulators may reflect the requirement for expression of different genes during terminal B-cell differentiation because different combinations of NF-kappa B/Rel family members preferentially activate distinct kappa B sites in reporter constructs

The Education System in Mexico

Over the last three decades, a significant amount of research has sought to relate educational institutions, policies, practices and reforms to social structures and agencies. A number of models have been developed that have become the basis for attempting to understand the complex relation between education and society. At the same time, national and international bodies tasked with improving educational performances seem to be writing in a void, in that there is no rigorous theory guiding their work, and their documents exhibit few references to groups, institutions and forces that can impede or promote their programmes and projects. As a result, the recommendations these bodies provide to their clients display little to no comprehension of how and under what conditions the recommendations can be put into effect. The Education System in Mexico directly addresses this problem. By combining abstract insights with the practicalities of educational reforms, policies, practices and their social antecedents, it offers a long overdue reflection of the history, effects and significance of the Mexican educational system, as well as presenting a more cogent understanding of the relationship between educational institutions and social forces in Mexico and around the world

Chemistry in isolation: High CCH/HCO+ line ratio in the AMIGA galaxy CIG 638

Multi-molecule observations towards an increasing variety of galaxies have been showing that the relative molecular abundances are affected by the type of activity. However, these studies are biased towards bright active galaxies, which are typically in interaction. We study the molecular composition of one of the most isolated galaxies in the local Universe where the physical and chemical properties of their molecular clouds have been determined by intrinsic mechanisms. We present 3 mm broad band observations of the galaxy CIG 638, extracted from the AMIGA sample of isolated galaxies. The emission of the J=1-0 transitions of CCH, HCN, HCO+, and HNC are detected. Integrated intensity ratios between these line are compared with similar observations from the literature towards active galaxies including starburst galaxies (SB), active galactic nuclei (AGN), luminous infrared galaxies (LIRG), and GMCs in M33. A significantly high ratio of CCH with respect to HCN, HCO+, and HNC is found towards CIG 638 when compared with all other galaxies where these species have been detected. This points to either an overabundance of CCH or to a relative lack of dense molecular gas as supported by the low HCN/CO ratio, or both. The data suggest that the CIG 638 is naturally a less perturbed galaxy where a lower fraction of dense molecular gas, as well as a more even distribution could explain the measured ratios. In this scenario the dense gas tracers would be naturally dimmer, while the UV enhanced CCH, would be overproduced in a less shielded medium.Comment: Letter accepted for publication in A&

Observing the CMB at High-l using the VSA and AMI

We discuss two experiments - the Very Small Array (VSA) and the Arcminute MicroKelvin Imager (AMI) - and their prospects for observing the CMB at high angular multipoles. Whilst the VSA is primarily designed to observe primary anisotropies in the CMB, AMI is designed to image secondary anisotropies via the Sunyaev-Zel'dovich effect. The combined l-range of these two instruments is between l = 150 and ~10000.Comment: 8 pages, 13 figures. To be published in the proceedings of "The Cosmic Microwave Background and its Polarization", New Astronomy Reviews, (eds. S. Hanany and K.A. Olive

Physiological Responses to Acute Silver Exposure in the Freshwater Crayfish (\u3cem\u3eCambarus diogenes diogenes\u3c/em\u3e)—A Model Invertebrate?

Adult crayfish (Cambarus diogenes diogenes) exposed to 8.41 ± 0.17 μg silver/L (19.4% as Ag+) in moderately hard freshwater under flow-through conditions for 96 h exhibited ionoregulatory disturbance, elevated metabolic ammonia (Tamm) production and substantial silver accumulation in the gills, hemolymph, and hepatopancreas. The ionoregulatory disturbance included both a generally reduced unidirectional Na1 influx and an increased unidirectional Na+ efflux, leading to a substantial net loss of Na+ from the silver-exposed crayfish. The Na+ uptake in silver-exposed crayfish differed overall from controls, while the increased Na+ efflux recovered to control values 48 h into the 96 h of exposure. The general inhibition of Na+ uptake could be explained by a reduced sodium/potassium-adenosine triphosphatase (Na/K-ATPase) activity in terminally obtained gill samples from the silver exposed crayfish. The silver-induced effect on Na+ uptake and loss translated to reduced hemolymph Na+ concentrations but not significantly reduced hemolymph Cl- concentrations. Hemolymph Tamm and Tamm efflux both increased in silver-exposed crayfish, indicating an increased metabolic Tamm production. The present study demonstrates that the toxic mechanism of waterborne silver exposure in freshwater crayfish resembles that of freshwater teleost fish. The crayfish might therefore be a useful model system for extending current environmental regulatory strategies, currently based on teleost fish, to invertebrates