Evaluation of criteria for allocating intelligent transport system check sites

The article analyzes a recent stage of the road network structure in the Slovak republic and suggests development trends in building highways and lower class roads. The route network structure, its qualitative parameters, negotiability and loading condition intensity change seasonally. These aspects have a cardinal influence on the loading condition development of route network, which consequently influences the necessity of allocation and sequence of means of transport check devices building

The two dimensional XY model at the transition temperature: A high precision Monte Carlo study

We study the classical XY (plane rotator) model at the Kosterlitz-Thouless phase transition. We simulate the model using the single cluster algorithm on square lattices of a linear size up to L=2048.We derive the finite size behaviour of the second moment correlation length over the lattice size xi_{2nd}/L at the transition temperature. This new prediction and the analogous one for the helicity modulus are confronted with our Monte Carlo data. This way beta_{KT}=1.1199 is confirmed as inverse transition temperature. Finally we address the puzzle of logarithmic corrections of the magnetic susceptibility chi at the transition temperature.Comment: Monte Carlo results for xi/L in table 1 and 2 corrected. Due to a programming error,these numbers were wrong by about a factor 1+1/L^2. Correspondingly the fits with L_min=64 and 128 given in table 5 and 6 are changed by little.The central results of the paper are not affected. Wrong sign in eq.(52) corrected. Appendix extende

Direct determination of vibrational density of states change on ligand binding to a protein

The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined by the density of states change, is found to contribute significantly to the binding equilibrium

Report on the Workshop on Personal Knowledge Graphs (PKG 2021) at AKBC 2021

The term personal knowledge graph (PKG) has been broadly used to refer to structured representation of information about a given user, primarily in the form of entities that are personally related to the user. The potential of personal knowledge graphs as a means of managing and organizing personal data, as well as a source of background knowledge for personalizing downstream services, has recently gained increasing attention from researchers in multiple fields, including that of Information Retrieval, Natural Language Processing, and the Semantic Web. The goal of the PKG’21 workshop was to create a forum for researchers and practitioners from diverse areas to present and discuss methods, tools, techniques, and experiences related to the construction and use of personal knowledge graphs, identify open questions, and create a shared research agenda. It successfully brought about a diverse workshop program, comprising an invited keynote, paper presentations, and breakout discussions, as a half-day event at the 3rd Automated Knowledge Base Construction (AKBC’21) conference. The workshop demonstrated that while the concept and research field of personal knowledge graphs is still in its early stages, there are many promising avenues of future development and research that already, and independently, have attracted the interest of several different communities.publishedVersio

The effects of Kv1.3 and IKCa1 channel inhibition on cytokine production and calcium influx of T lymphocytes in rheumatoid arthritis and ankylosing spondylitis

Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined calcium influx kinetics and its sensitivity to Kv1.3 and IKCa1 channel inhibition following PHA activation in CD4, Th1, Th2 and CD8 cells as well as monocytes. The application of TRAM resulted in a lower production of TNF-a and IL1-RA in all three study groups. Inhibition by TRAM had contrary effects on the production of IL-1b and IL-5: While their production was increased by PBMCs of RA patients, this effect was not observed in HD and AS PBMCs. While treatment with MGTX resulted in a similar decrease in calcium influx in the CD4 and Th2 subsets across all study groups, TRAM treatment had opposite effects on RA and HD samples: It decreased calcium influx in the Th2 and CD8 subsets in RA, while only Th1 cells were affected in HDs. The effects of IKCa1 channel inhibition are controversial in samples of RA and AS patients, since it shifts the inflammatory balance into the pro-inflammatory direction

WHAT WAY DETERMINE THE CORRECT ALLOCATION AND LAYOUT FOR THE NEEDS OF PARKING FREIGHT DESIGN IN CONCRETE REGION

In terms of building a network parking strategies for freight transport may be considered two variants: a building (completing) car parks on abandoned of border crossings, respectively building a whole new network of parks. Creating a network of parks for freight is in the interest of the Slovak Republic as well as the European Union. The subsequent optimization is dependent on the quality of road infrastructure and the traffic intensity in the monitored sections. It is therefore important selection of suitable candidates, administrators and their subsequent assessment of the appropriateness and services provided in selected locations. Identification of parking in the SR enables to choose the effective solution for intelligent networking and secure parking

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.

Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual phosphorylation events within the multisite phosphorylation process have never been thoroughly studied. In Saccharomyces cerevisiae, the initiation of S phase is thought to be governed by complexes of Cdk1 and Cln cyclins that phosphorylate six or more sites on the Clb5-Cdk1 inhibitor Sic1, directing it to SCF-mediated destruction. The resulting Sic1-free Clb5-Cdk1 complex triggers S phase. Here, we demonstrate that Sic1 destruction depends on a more complex process in which both Cln2-Cdk1 and Clb5-Cdk1 act in processive multiphosphorylation cascades leading to the phosphorylation of a small number of specific phosphodegrons. The routes of these phosphorylation cascades are shaped by precisely oriented docking interactions mediated by cyclin-specific docking motifs in Sic1 and by Cks1, the phospho-adaptor subunit of Cdk1. Our results indicate that Clb5-Cdk1-dependent phosphorylation generates positive feedback that is required for switch-like Sic1 destruction. Our evidence for a docking network within clusters of phosphorylation sites uncovers a new level of complexity in Cdk1-dependent regulation of cell cycle transitions, and has general implications for the regulation of cellular processes by multisite phosphorylation

An Ecosystem for Personal Knowledge Graphs: A Survey and Research Roadmap

This paper presents an ecosystem for personal knowledge graphs (PKG), commonly defined as resources of structured information about entities related to an individual, their attributes, and the relations between them. PKGs are a key enabler of secure and sophisticated personal data management and personalized services. However, there are challenges that need to be addressed before PKGs can achieve widespread adoption. One of the fundamental challenges is the very definition of what constitutes a PKG, as there are multiple interpretations of the term. We propose our own definition of a PKG, emphasizing the aspects of (1) data ownership by a single individual and (2) the delivery of personalized services as the primary purpose. We further argue that a holistic view of PKGs is needed to unlock their full potential, and propose a unified framework for PKGs, where the PKG is a part of a larger ecosystem with clear interfaces towards data services and data sources. A comprehensive survey and synthesis of existing work is conducted, with a mapping of the surveyed work into the proposed unified ecosystem. Finally, we identify open challenges and research opportunities for the ecosystem as a whole, as well as for the specific aspects of PKGs, which include population, representation and management, and utilization

Finite Temperature Correlation Functions in Integrable QFT

Finite temperature correlation functions in integrable quantum field theories are formulated only in terms of the usual, temperature-independent form factors, and certain thermodynamic filling fractions which are determined from the thermodynamic Bethe ansatz. Explicit expressions are given for the one and two-point functions.Comment: 25 pages, 3 figures. In Latex. Uses Revte

Lucene4IR: Developing information retrieval evaluation resources using Lucene

The workshop and hackathon on developing Information Retrieval Evaluation Resources using Lucene (L4IR) was held on the 8th and 9th of September, 2016 at the University of Strathclyde in Glasgow, UK and funded by the ESF Elias Network. The event featured three main elements: (i) a series of keynote and invited talks on industry, teaching and evaluation; (ii) planning, coding and hacking where a number of groups created modules and infrastructure to use Lucene to undertake TREC based evaluations; and (iii) a number of breakout groups discussing challenges, opportunities and problems in bridging the divide between academia and industry, and how we can use Lucene for teaching and learning Information Retrieval (IR). The event was composed of a mix and blend of academics, experts and students wanting to learn, share and create evaluation resources for the community. The hacking was intense and the discussions lively creating the basis of many useful tools but also raising numerous issues. It was clear that by adopting and contributing to most widely used and supported Open Source IR toolkit, there were many benefits for academics, students, researchers, developers and practitioners - providing a basis for stronger evaluation practices, increased reproducibility, more efficient knowledge transfer, greater collaboration between academia and industry, and shared teaching and training resources