Minority Protagonists in the Young Adult Historical Fiction Novel

In young adult literature, the reader finds most of the same genres as are available for adult fiction. One of the challenges that readers of young adult literature face is that, although some progress has been made to develop and feature minority characters and protagonists, minorities are still underrepresented in young adult literature. Although young adult historical fiction features more minority protagonists, this is ordinarily done because historical fiction lends itself as an educational tool, where history, geography, and social studies can be illuminated through the genre. As demographics in the United States continue to change and as minority groups have greater representation in the U. S., young adult literature should include more minority protagonists

Extensive Gene-Specific Translational Reprogramming in a Model of B Cell Differentiation and Abl-Dependent Transformation

To what extent might the regulation of translation contribute to differentiation programs, or to the molecular pathogenesis of cancer? Pre-B cells transformed with the viral oncogene v-Abl are suspended in an immortalized, cycling state that mimics leukemias with a BCR-ABL1 translocation, such as Chronic Myelogenous Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL). Inhibition of the oncogenic Abl kinase with imatinib reverses transformation, allowing progression to the next stage of B cell development. We employed a genome-wide polysome profiling assay called Gradient Encoding to investigate the extent and potential contribution of translational regulation to transformation and differentiation in v-Abl-transformed pre-B cells. Over half of the significantly translationally regulated genes did not change significantly at the level of mRNA abundance, revealing biology that might have been missed by measuring changes in transcript abundance alone. We found extensive, gene-specific changes in translation affecting genes with known roles in B cell signaling and differentiation, cancerous transformation, and cytoskeletal reorganization potentially affecting adhesion. These results highlight a major role for gene-specific translational regulation in remodeling the gene expression program in differentiation and malignant transformation

A many-analysts approach to the relation between religiosity and well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β=0.120). For the second research question, this was the case for 65% of the teams (median reported β=0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

A Many-analysts Approach to the Relation Between Religiosity and Well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N = 10, 535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β = 0.120). For the second research question, this was the case for 65% of the teams (median reported β = 0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

Proceedings of the Fourth Caldwell Conference, St. Catherines Island, Georgia, March 27-29, 2009.

391 p. : ill. (chiefly col.), maps (chiefly col.) ; 26 cm. "Issued March 23, 2011."This edited volume addresses the geoarchaeology of St. Catherines Island (Georgia). The field of geoarchaeology has typically been defined as either geology pursued within an archaeological framework or (sometimes the reverse) as archaeology framed with the help of geological methodology. Either way, the formalized objectives of geoarchaeology define a broad range of pursuits, from placing archaeological sites into relative and absolute temporal context through the application of stratigraphic principles and absolute dating techniques, to understanding the natural processes of site formation, to reconstructing the landscapes that existed around a site or group of sites at the time of occupation. The editors of this volume have generally followed the lead of G.R. Rapp and C.L. Hill (2006, Geoarchaeology : the earth-science approach to archaeological interpretation) by stressing the importance of multiple viewpoints and methodologies in applying geoscience techniques to evaluate the archaeological record. In the broadest sense, then, Geoarchaeology of St. Catherines Island applies multiple earth science concepts, techniques, or knowledge bases to the known archaeological record and the processes that created that record. This volume consists of 16 papers presenting the newest research on the stratigraphic and geomorphological evolution of the St. Catherines Island landscape. Of particular interest are presentations addressing the relative timing and nature of sedimentation, paleobiology, sea level change, stream capture, hydrology, and erosional patterning evident on St. Catherines Island (and to some degree the rest of the Georgia Bight). These papers were initially presented at the Fourth Caldwell Conference, cosponsored by the American Museum of Natural History and the St. Catherines Island Foundation, held on St. Catherines Island (Georgia), March 27-29, 2009. Table of contents: Why this archaeologist cares about geoarchaeology : some pasts and futures of St. Catherines Island / David Hurst Thomas -- Evolution of late Pleistocene-Holocene climates and environments of St. Catherines Island and the Georgia Bight / Fredrick J. Rich, Anthony Vega, and Frank J. Vento -- Geoarchaeological research at St. Catherines Island : defining the geological foundation / Gale A. Bishop, Brian K. Meyer, R. Kelly Vance, and Fredrick J. Rich -- Development of a late Pleistocene-Holocene genetic stratigraphic framework for St. Catherines Island : archaeological implications / Frank J. Vento and Patty A. Stahlman -- Ichnological diagnosis of ancient storm-washover fans, Yellow Banks Bluff, St. Catherines Island / Anthony J. Martin and Andrew K. Rindsberg -- Quaternary vegetation and depositional history of St. Catherines Island / Fredrick J. Rich and Robert K. Booth -- Recent shoreline erosion and vertical accretion patterns, St. Catherines Island / Donald B. Potter Jr. -- Role of storm events in beach ridge formation, St. Catherines Island / Harold B. Rollins, Kathi Beratan, and James E. Pottinger -- Drainage changes at Ossabaw, St. Catherines, and Sapelo sounds and their influence on island morphology and spit building on St. Catherines Island / Timothy M. Chowns -- Vibracores and vibracore transects : constraining the geological and cultural history of St. Catherines Island / Gale A. Bishop, David Hurst Thomas, Matthew C. Sanger, Brian K. Meyer, R. Kelly Vance, Robert K. Booth, Fredrick J. Rich, Donald B. Potter, and Timothy Keith-Lucas -- Application of ground penetrating radar to investigations of the stratigraphy, structure, and hydrology of St. Catherines Island / R. Kelly Vance, Gale A. Bishop, Fredrick J. Rich, Brian K. Meyer, and Eleanor J. Camann -- Postsettlement dispersal and dynamic repopulation of estuarine habitats by adult Mercenaria mercenaria, St. Catherines Island / Robert S. Prezant, Harold B. Rollins, and Ronald B. Toll -- The foundation for sea turtle geoarchaeology and zooarchaeology : morphology of recent and ancient sea turtle nests, St. Catherines Island, Georgia, and Cretaceous Fox Hills Sandstone, Elbert County, Colorado / Gale A. Bishop, Fredric L. Pirkle, Brian K. Meyer, and William A. Pirkle -- Sea turtle habitat deterioration on St. Catherines Island : defining the modern transgression / Gale A. Bishop and Brian K. Meyer -- Modeling indigenous hunting and harvesting of sea turtles and their eggs on the Georgia Coast / Gale A. Bishop, David Hurst Thomas, and Brian K. Meyer -- Geomorphology, sea level, and marine resources : St. Catherines Island / Harold B. Rollins and David Hurst Thomas -- Appendix 1. Noncultural radiocarbon record from St. Catherines Island : a compendium -- Appendix 2. Vibracore record from St. Catherines Island : a compendium.Conference sponsored by the American Museum of Natural History and the St. Catherines Island Foundation

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The impact of using an intraoperative goal directed fluid therapy protocol on clinical outcomes in patients undergoing total pancreatectomy and islet cell autotransplantation.

BACKGROUND: Patients undergoing total pancreatectomy and islet cell autotransplant (TPIAT) for treatment of pancreatitis are at risk for complications of over and under resuscitation. We hypothesized that using a goal directed fluid therapy (GDFT) protocol might impact clinical outcomes. MATERIALS AND METHODS: A consecutive series of adult patients undergoing TPIAT were managed intraoperatively using either standard fluid therapy (SFT, n = 44) or GDFT (n = 23) as part of a pilot study between January 2013 and May 2015. Patient characteristics, intraoperative, and postoperative data were recorded prospectively, then retrospectively analyzed for differences between the groups. RESULTS: The GDFT group had lower total fluid resuscitation (3,240 cc vs 5,173 cc, p \u3c 0.0001) and transfusion requirements (1.0 cc/kg vs 3.3 cc/kg, p = 0.050) compared to the SFT group. The pre to postop nadir hemoglobin change was significantly less for GDFT (4.2 vs 5.1 gm/dl, p = 0.021) despite less transfusion. CONCLUSIONS: Compared to SFT, using an intraoperative GDFT protocol in TPIAT patients was associated with significantly decreased intraoperative fluid resuscitation, blood transfusion and less postoperative dilutional anemia, without any difference in complications of underresuscitation. This pilot study suggests that GDFT is likely safe and further investigation is warranted

Hypothermia after CPR prolongs conduction times of somatosensory evoked potentials

To investigate the effect of mild hypothermia on conduction times and amplitudes of median nerve somatosensory evoked potentials (SEP) in patients after cardiopulmonary resuscitation (CPR). Patients treated with hypothermia after CPR who underwent SEP recording during hypothermia and after rewarming were selected from a prospectively collected database. Latencies and amplitudes of N9 (peripheral conduction time, PCT), N13, and N20 were measured. The central conduction time (CCT) was defined as peak-peak latency N13-N20. Recordings of 25 patients were assessed by a second observer to determine the intraclass correlation coefficient (ICC). A total of 115 patients were included. The mean body temperature at SEP during hypothermia was 33.1 °C (SD 0.8) and after rewarming 37.1 °C (SD 0.8). Mean latencies of N9, N13, and N20 and mean CCT were longer during hypothermia. There were no consistent differences in amplitudes. There was an almost perfect ICC for assessment of latencies and amplitudes. This study showed that PCT and CCT of median nerve SEP were prolonged during treatment with hypothermia after CPR compared with after rewarming. Amplitudes did not differ consistentl