Halo occupation distribution modelling of green valley galaxies

We present a clustering analysis of near-ultraviolet (NUV)–optical colour selected luminosity bin samples of green valley galaxies. These galaxy samples are constructed by matching the Sloan Digital Sky Survey Data Release 7 with the latest Galaxy Evolution Explorer source catalogue which provides NUV photometry. We present cross-correlation function measurements and determine the halo occupation distribution of green valley galaxies using a new multiple tracer analysis technique. We extend the halo occupation formalism, which describes the relation between galaxies and halo mass in terms of the probability P(N, Mh) that a halo of given mass Mh contains N galaxies, to model the cross-correlation function between a galaxy sample of interest and multiple tracer populations simultaneously. This method can be applied to commonly used luminosity threshold samples as well as to colour and luminosity bin selected galaxy samples, and improves the accuracy of clustering analyses for sparse galaxy populations. We confirm the previously observed trend that red galaxies reside in more massive haloes and are more likely to be satellite galaxies than average galaxies of similar luminosity. While the change in central galaxy host mass as a function of colour is only weakly constrained, the satellite fraction and characteristic halo masses of green satellite galaxies are found to be intermediate between those of blue and red satellite galaxies

Towards Symbolic Model-Based Mutation Testing: Combining Reachability and Refinement Checking

Model-based mutation testing uses altered test models to derive test cases that are able to reveal whether a modelled fault has been implemented. This requires conformance checking between the original and the mutated model. This paper presents an approach for symbolic conformance checking of action systems, which are well-suited to specify reactive systems. We also consider nondeterminism in our models. Hence, we do not check for equivalence, but for refinement. We encode the transition relation as well as the conformance relation as a constraint satisfaction problem and use a constraint solver in our reachability and refinement checking algorithms. Explicit conformance checking techniques often face state space explosion. First experimental evaluations show that our approach has potential to outperform explicit conformance checkers.Comment: In Proceedings MBT 2012, arXiv:1202.582

The Sol-gel process for nano-technologies : new nanocomposites with interesting optical and mechanical properties

Various nanocomposite systems have been synthesized by sol-gel routes. For this reason, prefabricated nanoparticles (SiO2 sols or boehmite powder) have been dispersed after surface modification in sol-gel-derived organically modified or polymeric ligand matrices. In all cases, a significant effect on dispersibility by surface modification could be observed. After curing, the mechanical or optical properties depend strongly on the dispersion and surface modification. Using these results, composites to be used in chip coupling and as hard coatings on polycarbonate and CR 39 have been developed

Quantum dot/antibody conjugates for in vivo cytometric imaging in mice

Multiplexed, phenotypic, intravital cytometric imaging requires novel fluorophore conjugates that have an appropriate size for long circulation and diffusion and show virtually no nonspecific binding to cells/serum while binding to cells of interest with high specificity. In addition, these conjugates must be stable and maintain a high quantum yield in the in vivo environments. Here, we show that this can be achieved using compact (~15 nm in hydrodynamic diameter) and biocompatible quantum dot (QD) -Ab conjugates. We developed these conjugates by coupling whole mAbs to QDs coated with norbornene-displaying polyimidazole ligands using tetrazine–norbornene cycloaddition. Our QD immunoconstructs were used for in vivo single-cell labeling in bone marrow. The intravital imaging studies using a chronic calvarial bone window showed that our QD-Ab conjugates diffuse into the entire bone marrow and efficiently label single cells belonging to rare populations of hematopoietic stem and progenitor cells (Sca1[superscript +]c-Kit[superscript +] cells). This in vivo cytometric technique may be useful in a wide range of structural and functional imaging to study the interactions between cells and between a cell and its environment in intact and diseased tissues.National Institutes of Health (U.S.) (Grant U54-CA151884)National Institutes of Health (U.S.) (Grant P41-EB015871-26A1)Samsung Scholarship Foundation (Graduate Student Fellowship)Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (Grant W911NF-07-D-0004

Gut microbiota composition as a candidate risk factor for dimethyl fumarate-induced lymphopenia in multiple sclerosis

Mounting evidence points towards a pivotal role of gut microbiota in multiple sclerosis (MS) pathophysiology. Yet, whether disease-modifying treatments alter microbiota composition and whether microbiota shape treatment response and side-effects remain unclear. In this prospective observational pilot study, we assessed the effect of dimethyl fumarate (DMF) on gut microbiota and on host/microbial metabolomics in a cohort of 20 MS patients. Combining state-of-the-art microbial sequencing, metabolome mass spectrometry, and computational analysis, we identified longitudinal changes in gut microbiota composition under DMF-treatment and an increase in citric acid cycle metabolites. Notably, DMF-induced lymphopenia, a clinically relevant safety concern, was correlated with distinct baseline microbiome signatures in MS patients. We identified gastrointestinal microbiota as a key therapeutic target for metabolic properties of DMF. By characterizing gut microbial composition as a candidate risk factor for DMF-induced lymphopenia, we provide novel insights into the role of microbiota in mediating clinical side-effects

Halo Occupation Distribution Modeling of Green Valley Galaxies

We present a clustering analysis of near ultraviolet (NUV) - optical color selected luminosity bin samples of green valley galaxies. These galaxy samples are constructed by matching the Sloan Digital Sky Survey Data Release 7 with the latest Galaxy Evolution Explorer source catalog which provides NUV photometry. We present cross-correlation function measurements and determine the halo occupation distribution of these transitional galaxies using a new multiple tracer analysis technique. We extend the halo-occupation formalism to model the cross-correlation function between a galaxy sample of interest and multiple tracer populations simultaneously. This method can be applied to commonly used luminosity threshold samples as well as to color and luminosity bin selected galaxy samples, and improves the accuracy of clustering analyses for sparse galaxy populations. We confirm the previously observed trend that red galaxies reside in more massive halos and are more likely to be satellite galaxies than average galaxies of similar luminosity. While the change in central galaxy host mass as a function of color is only weakly constrained, the satellite fraction and characteristic halo masses of green satellite galaxies are found to be intermediate between those of blue and red satellite galaxies.Comment: matches MNRAS accepted version; minor revisions, results unchange