Paternal Determinants in Preeclampsia

Preeclampsia is a condition associated with high rates of maternal-fetal morbidity and mortality. It usually occurs in 3–10% of nulliparous women and 18% of previously affected women. Different lines of evidence have demonstrated the role of the father in the onset of preeclampsia. The placenta is the cornerstone of preeclampsia and poses important paternal genetic determinants; in fact, the existence of a “paternal antigen” has been proposed. Nulliparity is a well-known risk factor. Change of partner to a woman without history of preeclampsia increases the risk; however, this change decreases in women with history of the condition. High interval between pregnancies, short sexual intercourse before pregnancy, and conception by intracytoplasmic sperm injection suggest a limited exposure to the so-called paternal antigen. A man who was born from a mother with preeclampsia also increases the risk to his partner. Not only maternal but also paternal obesity is a risk factor for preeclampsia. Fetal HLA-G variants from the father increased the immune incompatibility with the mother and are also significantly associated with preeclampsia in multigravida pregnancies. An analysis of a group of Swedish pregnant women showed that the risk for preeclampsia is attributable to paternal factors in 13% of cases, which could be related to genetic interactions with maternal genetic factors. This review aimed to evaluate the evidences of the father’s contribution to the onset of preeclampsia and determine the importance of including them in future studies

CYP2D6 polymorphism and its clinical implications

Artículo de Investigació

Effects of ozone exposure on the oxidative capacity for drug biotransformation in Wistar rats

Artículo de Investigació

Farmacoepidemiologia de psicoformccos empleados en 10 proctico pediotrico en el Servicio de Psiquiotrio Infantil del Hospital General de Durango, Mexico

Artículo de Investigació

Vascular Dysfunction in Mother and Offspring During Preeclampsia: Contributions from Latin-American Countries

Pregnancy is a physiologically stressful condition that generates a series of functional adaptations by the cardiovascular system. The impact of pregnancy on this system persists from conception beyond birth. Recent evidence suggests that vascular changes associated with pregnancy complications, such as preeclampsia, affect the function of the maternal and offspring vascular systems, after delivery and into adult life. Since the vascular system contributes to systemic homeostasis, defective development or function of blood vessels predisposesboth mother and infant to future risk for chronic disease. These alterations in later life range from fertility problems to alterations in the central nervous system or immune system, among others. It is important to note that rates of morbi-mortality due to pregnancy complications including preeclampsia, as well as cardiovascular diseases have a higher incidence in Latin American countries than in more developed countries. Nonetheless, there is a lack both in the amount and impact of research conducted in Latin America. An impact, althoughsmaller, can be seen when research in vascular disorders related to problems during pregnancy is analyzed. Therefore, in this review, information about preeclampsia and endothelial dysfunction generated from researchgroups based in Latin American countries will be highlighted. We relate the need, as present in many other countries in the world, for increased effective regional and international collaboration to generate new dataspecific to our region on this topic.Fil: Giachini, Fernanda Regina. Universidade Federal de Mato Grosso Do Sul. Centro de Ciencias Biológicas E Da Saude; BrasilFil: Galaviz Hernandez, Carlos. Instituto Politécnico Nacional; MéxicoFil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Viana, Marta. Universidad CEU San Pablo; EspañaFil: Cadavid, Angela. Universidad de Antioquia; ColombiaFil: Asturizaga, Patricia. Hospital Materno-infantil de la Caja Nacional de Salud; BoliviaFil: Teran, Enrique. Universidad San Francisco de Quito; EcuadorFil: Clapes, Sonia. Universidad de Ciencias Médicas de la Habana; CubaFil: Alcala, Martin. Universidad CEU San Pablo; EspañaFil: Bueno, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Calderón Domínguez, María. Universidad CEU San Pablo; EspañaFil: Ramos, María P.. Universidad CEU San Pablo; EspañaFil: Lima, Victor Vitorino. Universidad Federal de Mato Grosso; BrasilFil: Sosa Macias, Martha. Instituto Politécnico Nacional; MéxicoFil: Martinez, Nora Alicia. Universidad de Antioquia; ColombiaFil: Roberts, James M.. University of Pittsburgh; Estados UnidosFil: Escudero, Carlos. Universidad del Bio Bio; Chil