El plan de apoyo conductual positivo en el primer ciclo de Educación Infantil

Este estudio pretende analizar los efectos que tiene el plan de apoyo conductual positivo sobre las habilidades adaptativas, el comportamiento y el desarrollo socioemocional del alumnado del primer ciclo de Educación Infantil. Se evaluó la primera variable utilizando el Sistema de Evaluación de la Conducta Adaptativa (ABAS-II) y las dos últimas, el Infant Toddler Social Emotional Assessment (ITSEA). Los resultados mostraron una disminución estadísticamente significativa del comportamiento externalizante (Z=-2,418, p=,016), la falta de regulación (Z=-2,767, p=,006) y otras conductas poco adaptativas (Z=-2,357, p=,018), así como un incremento estadísticamente significativo de la competencia (Z=-2,959, p=,003), la comunicación (Z=-3,576, p=,000), el desarrollo social (Z=-3,622, p=,000), el ocio (Z=-3,542, p=,000), el autocuidado (Z=-3,361, p=,000), la autodirección (Z=-3,575, p=,000) y la adaptación a la escuela (Z=-3,662, p=,000). Son resultados que muestran la importancia que tiene crear un entorno escolar accesible y la necesidad de apoyar intencionadamente el desarrollo de las habilidades adaptativas en esta etapa educativa

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

El plan de apoyo conductual positivo en el primer ciclo de Educación Infantil

Este estudio pretende analizar los efectos que tiene el plan de apoyo conductual positivo sobre las habilidades adaptativas, el comportamiento y el desarrollo socioemocional del alumnado del primer ciclo de Educación Infantil. Se evaluó la primera variable utilizando el Sistema de Evaluación de la Conducta Adaptativa (ABAS-II) y las dos últimas, el Infant Toddler Social Emotional Assessment (ITSEA). Los resultados mostraron una disminución estadísticamente significativa del comportamiento externalizante (Z=-2,418, p=,016), la falta de regulación (Z=-2,767, p=,006) y otras conductas poco adaptativas (Z=-2,357, p=,018), así como un incremento estadísticamente significativo de la competencia (Z=-2,959, p=,003), la comunicación (Z=-3,576, p=,000), el desarrollo social (Z=-3,622, p=,000), el ocio (Z=-3,542, p=,000), el autocuidado (Z=-3,361, p=,000), la autodirección (Z=-3,575, p=,000) y la adaptación a la escuela (Z=-3,662, p=,000). Son resultados que muestran la importancia que tiene crear un entorno escolar accesible y la necesidad de apoyar intencionadamente el desarrollo de las habilidades adaptativas en esta etapa educativa

Effect of C-reactive protein on Fcγ receptor II in cultured bovine endothelial cells

A B S T R A C T The major CRP (C-reactive protein) receptor on leucocytes has been identified as the low-affinity IgG receptor Fcγ receptor II (CD32). Our aim was to assess whether inflammation may modify the presence of the CD32 receptor in BAEC (bovine aortic endothelial cells). Confocal microscopy experiments showed a weak expression of the CD32 receptor in control BAEC that was slightly increased by 10 µg/ml CRP. Incubation of BAEC with TNF-α (tumour necrosis factor-α) did not modify the fluorescence signal of CD32. Addition of CRP to TNF-α-incubated BAEC enhanced the fluorescence signal of the CD32 receptors. The CD32 receptors showed a perinuclear cytoplasmic localization in BAEC. An alteration of the NO (nitric oxide)-dependent vasorelaxation has been defined as endothelial dysfunction. Endothelial dysfunction has been associated with the presence of superoxide anion and with a reduction in the expression of the eNOS (endothelial NO synthase). A concentration of CRP similar to that detected in patients with cardiovascular risk (10 µg/ ml) failed to modify the generation of superoxide anion stimulated by TNF-α. Western blot experiments showed that TNF-α decreased the expression of the eNOS protein, which was partially protected by treatment with 10 µg/ml CRP. The protective effect of 10 µg/ml CRP on eNOS expression in TNF-α-incubated BAEC was prevented by an antibody against CD32 receptors. In conclusion, the present results suggest that, although CRP has been associated with inflammation, CRP may protect the expression of eNOS protein against pro-inflammatory mediators such as TNF-α

Role of age and comorbidities in mortality of patients with infective endocarditis.

The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327  There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th