Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie-Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria

Sabatia Stagna. Il comprensorio del lago di Bracciano in età romana: atlante dei siti (parte terza)

Aggiornamento dell'Atlante dei Siti di età romana antica intorno al Lago di Bracciano (Progetto Sabatia Stagna - Univ. di Siena), che così porta il loro nr. complessivo a 21

Grosseto. Città etrusca di Roselle: indagini non invasive e saggi di scavo nel settore orientale

Il contributo illustra in dettaglio il resoconto dell'attività condotta sull'area del Parco Archeologico di Roselle nell'anno 201

ENUBET: A monitored neutrino beam for high precision cross section measurements

International audienceThe main source of systematic uncertainty on neutrino cross section measurements at the GeV scale is represented by the poor knowledge of the initial flux. The goal of cutting down this uncertainty to 1% can be achieved through the monitoring of charged leptons produced in association with neutrinos, by properly instrumenting the decay region of a conventional narrow-band neutrino beam. Large angle muons and positrons from kaons are measured by a sampling calorimeter on the decay tunnel walls (tagger), while muon stations after the hadron dump can be used to monitor the neutrino component from pion decays. This instrumentation can provide a full control on both the muon and electron neutrino fluxes at all energies. Furthermore, the narrow momentum width (<10%) of the beam provides a O(10%) measurement of the neutrino energy on an event by event basis, thanks to its correlation with the radial position of the interaction at the neutrino detector. The ENUBET project has been funded by the ERC in 2016 to prove the feasibility of such a monitored neutrino beam and is cast in the framework of the CERN neutrino platform (NP06) and the Physics Beyond Colliders initiative. In our contribution, we summarize the ENUBET design, physics performance and opportunities for its implementation in a timescale comparable with next long baseline neutrino experiments

Lepton reconstruction in the ENUBET tagger

The ENUBET project aims at demonstrating the feasibility of a monitored neutrino beam in which the measurement of associated charged leptons in the instrumented decay region of a conventional beam is used to constrain the neutrino flux to unprecedented precision ($\mathcal{O}$(1\%)). Large angle muons and positrons from kaon decays are detected on the decay tunnel walls equipped with a sampling calorimeter with longitudinal, radial and azimuthal segmentation. After a brief description of the ENUBET beamline and of the detectors employed in the lepton tagger, the analysis chain for the event reconstruction, the background suppression and the identification of positrons and muons will be described