5,325 research outputs found
A QCD sum rule calculation of the decay width
To understand the nature of the , recently observed in the mass
spectrum of the system by the D0 Collaboration, we have
investigated, in a previous work, a scalar tetraquark (diquak-antidiquark)
structure for it, within the two-point QCD sum rules method. The result found
for its mass agrees well with the experimental value. Encouraged by this
finding we now extend our calculations to obtain the decay width of
to using the three-point QCD sum rule. We obtain a value of
(20.4\pm8.7)\MeV, which, on comparing with the experimental value of
21.9\pm6.4 (\mbox{sta})^{+5.0}_{-2.5}(\mbox{syst}) \MeV/c^2, reinforces the
scalar four quark nature of .Comment: Minor modifications made. Some new discussions and references adde
IMMUNEPOTENT CRP enhances cyclophosphamide-induced cytotoxicity through a caspase independent but ROS dependent mechanism in triple negative-breast cancer cells
Background: Breast cancer (BC) is one of the leading causes of cancer death worldwide. Cyclophosphamide (CYP) remains a mainstay in cancer therapy mainly in the triple negative breast cancer subtype (TNBC) in spite of harmful adverse effects and cell death-resistances. To face this, combination of chemotherapies and immunotherapies has been proposed. IMMUNEPOTENT CRP (ICRP) is an immunotherapy that has cytotoxic effects in several cancer cells without affecting peripheral blood mononuclear cells (PBMC) and CD3+ cells, beside improving clinical parameters of chemotherapy-treated patients. The aim of this study was to evaluate the mechanism of cytotoxicity induced by ICRP in combination with CYP (ICRP+CYP) in TNBC cells and their effect in healthy cells.
Methods: For this purpose, human and murine breast adenocarcinoma, MDA-MB-231 and 4T1 cells, beside PBMC were treated for 24 hours with ICRP, CYP or ICRP+CYP in different combination ratios for the assessment of cell death. Flow cytometry was used to determine biochemical characteristics of cell death.
Results: ANN/PI assays showed that ICRP+CYP induce cell cycle arrest in TNBC cells and potentiated cell death characterized by loss of mitochondrial membrane potential, reactive oxygen species (ROS) production and caspases activation. In addition, ICRP+CYP-cell death is ROS-dependent and caspases-independent in MDA-MB-231 and 4T1 cells. On the other hand, ICRP did not affect CYP-cytotoxicity in PBMC.
Conclusions: For all the above, we can propose that the combination of ICRP with CYP is an effective combination therapy, promoting their use even in tumoral cells with defects on proteins implicated in the apoptotic pathway
Glow discharge mixture of Ar/He
Glow discharge mixture of Ar/He at a pressure of 266.66 Pa is experimentally investigated by opticalemission spectroscopy and double Langmuir probe at various mixture compositions. The species observedwere He I and Ar I. The electron temperature was found to be less than 10 eV, and the ion densityin the order of 1010 cm-3
Radiative corrections to the Dalitz plot of K_{l3}^\pm decays
We calculate the model-independent radiative corrections to the Dalitz plot
of K_{l3}^\pm decays to order (\alpha/\pi)(q/M_1), where q is the momentum
transfer and M_1 is the mass of the kaon. The final results are presented,
first, with the triple integration over the variables of the bremsstrahlung
photon ready to be performed numerically and, second, in an analytical form.
These two forms are useful to crosscheck on one another and with other
calculations. This paper is organized to make it accessible and reliable in the
analysis of the Dalitz plot of precision experiments and is not compromised to
fixing the form factors at predetermined values. It is assumed that the real
photons are kinematically discriminated. Otherwise, our results have a general
model-independent applicability.Comment: RevTex4, 38 pages, 5 figures, 5 tables; some typos corrected;
discussion extended to compare with other result
Design of a rib impactor equipment
The human ribs must be analyzed as long and as curved bones, due to their physiology. For the development of an experimental equipment that simulate the application of loads, over the rib in the moment of a frontal collision in an automobile with seat belt, it was applied a methodology that constituted in the identification of needs and the variables which led the design of 3D model, from this it was used the technique of fused deposition modeling for the development of the equipment pieces. The supports that hold the rib ends were design with two and three degrees of freedom that allows the simulation of rib movement with the spine and the breastbone in the breathing. For the simulation of the seat belt, it was determined to applied two loads over the front part of the rib from the sagittal and lateral plane respectively, for this it was made a displacement through a lineal actuator with a speed of 4mm/s. The outcomes shown a design of an equipment able to obtain the load parameters required to generate fractures in rib specimens. The equipment may be used for the study of specimens with nearby geometries to the rib taken as a reference
The exergy costs of electrical power, cooling, and waste heat from a hybrid system based on a solid oxide fuel cell and an absorption refrigeration system
This paper applies the Exergy Cost Theory (ECT) to a hybrid system based on a 500 kWe solid oxide fuel cell (SOFC) stack and on a vapor-absorption refrigeration (VAR) system. To achieve this, a model comprised of chemical, electrochemical, thermodynamic, and thermoeconomic equations is developed using the software, Engineering Equation Solver (EES). The model is validated against previous works. This approach enables the unit exergy costs (electricity, cooling, and residues) to be computed by a productive structure defined by components, resources, products, and residues. Most importantly, it allows us to know the contribution of the environment and of the residues to the unit exergy cost of the product of the components. Finally, the simulation of different scenarios makes it possible to analyze the impact of stack current density, fuel use, temperature across the stack, and anode gas recirculation on the unit exergy costs of electrical power, cooling, and residues
Note: "Lock-in accelerometry" to follow sink dynamics in shaken granular matter
Understanding the penetration dynamics of intruders in granular beds is
relevant not only for fundamental Physics, but also for geophysical processes
and construction on sediments or granular soils in areas potentially affected
by earthquakes. While the penetration of intruders in two dimensional (2D)
laboratory granular beds can be followed using video recording, it is useless
in three dimensional (3D) beds of non-transparent materials such as common
sand. Here we propose a method to quantify the sink dynamics of an intruder
into laterally shaken granular beds based on the temporal correlations between
the signals from a reference accelerometer fixed to the shaken granular bed,
and a probe accelerometer deployed inside the intruder. Due to its analogy with
the working principle of a lock in amplifier, we call this technique Lock in
accelerometry (LIA). During Earthquakes, some soils can lose their ability to
sustain shear and deform, causing subsidence and sometimes substantial building
damage due to deformation or tumblin
Alternative symplectic structures for SO(3,1) and SO(4) four-dimensional BF theories
The most general action, quadratic in the B fields as well as in the
curvature F, having SO(3,1) or SO(4) as the internal gauge group for a
four-dimensional BF theory is presented and its symplectic geometry is
displayed. It is shown that the space of solutions to the equations of motion
for the BF theory can be endowed with symplectic structures alternative to the
usual one. The analysis also includes topological terms and cosmological
constant. The implications of this fact for gravity are briefly discussed.Comment: 13 pages, LaTeX file, no figure
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