Estudio de la espectroscopia y acción laser de los sistemas Nd3+:SBN e Yb3+SBN durante transiciones de fase

Tesis doctoral inédita. Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Física de Materiales. Fecha de lectura: 15-01-201

Micro-Raman characterization of Zn-diffused channel waveguides in Tm3+: LiNbO3

This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OE.18.005449. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under la

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMThe spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF3:Nd3+, SrF2:Nd3+, NaGdF4: Nd3+, NaYF4: Nd3+, KYF4: Nd3+, GdVO4: Nd3+, and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a "universal" optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymium-doped nanoparticle to be preferentially used in each caseThis project has been supported by the Spanish Ministerio de Economıa y Competitividad under Project No. MAT2013- 47395-C4-1-R. B. del Rosal thanks Universidad Autónoma de Madrid for an FPI grant. M. Misiak and A. Bednarkiewicz acknowledge the support from POIG.01.01.02-02-002/08 project financed by the European Regional Development Fund (Operational Programme Innovative Economy, 1.1.2). Yu. Orlovskii and A. Vanetsev acknowledge the support from the Centre of Excellence TK114 “Mesosystems: Theory and Applications”; TK117 “High-Technology Materials for Sustainable Development” and European Social Fund, Project No. #MTT50. Dragana Jovanovic and Miroslav Dramicanin acknowledge financial support of the Ministry of Education, Science and Technological development of the Republic of Serbia (Grant No. 45020). The authors are grateful to G. Drazic for TEM measurements of GdVO4 nanoparticles. The authors also thank the Brazilian agencies FAPEAL-Fundacao de Amparo a Pesquisa do Estado de Alagoas (Project No. PRONEX 2009-09-006), FINEP (Financiadora de Estudos e Projetos), CNPq (Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico) through Grant INCT NANO(BIO)SIMES, and D. Jaque (Pesquisador Visitante Especial (PVE)-CAPES) thanks CAPES (Coordenadoria de Aperfeic¸oamento de Pessoal de Ensino Superior) for the Project PVE No. A077/2013. K.U.K. is a Postdoctoral fellow of the Project PVE A077/2013. E. Navarro is funded by National Council for Science and Technology in Mexico CONACyT (Scholarship Ref. No. 207858/2014). Partial support from DGAPA-UNAM (Grant No. 109913) was gratefully acknowledged. A. S. and M. P. gratefully acknowledge Fondazione Cariverona (Verona, Italy) for financial support in the framework of the “Verona Nanomedicine Initiative

The role of tissue fluorescence in in vivo optical bioimaging

The following article appeared in Journal of Applied Physics 128.17 (2020): 171101 and may be found at https://doi.org/10.1063/5.0021854The technological advancements made in optics and semiconductors (e.g., cameras and laser diodes) working with infrared have brought interest in optical bioimaging back to the forefront of research investigating in vivo medical imaging techniques. The definition of the near-infrared transparency windows has turned optical imaging into more than just a method for topical imaging applications. Moreover, this has focused attention back to tissue fluorescence, emissions by tissues and organs that occur when excited by external illumination sources. Most endogenous fluorophores emit in the blue to green range of the electromagnetic spectrum and the resulting tissue fluorescence can be employed in studies from cells to tissue metabolism or avoided by shifting to the red if seen as unwanted autofluorescence. With the more recent move to infrared, it was discovered that autofluorescence is not limited to the visible but also strongly affects in vivo imaging in the infrared. In this Tutorial, we give an overview on tissue fluorescence and tissue interactions with excitation light as well as their effect on in vivo imaging. Furthermore, potential sources of tissue fluorescence in the near-infrared are identified and we describe approaches for successful biomedical imaging in the biological windows, taking into consideration infrared autofluorescence and summarizing techniques for avoiding it in in vivo imaging experimentsThis work was supported by the Spanish Ministry of Economy and Competitiveness under Project No. MAT2016-75362-C3-1-R, the Spanish Ministry of Sciences, Innovation and Universities under Project No. PID2019-106211RB-I00 (NANONERV), by the Instituto de Salud Carlos III (Nos. PI16/00812 and PI19/00565), and through the Comunidad Autónoma de Madrid (No. B2017/ BMD-3867RENIMCM), and co-financed by the European Structural and investment fund. Additional funding was provided by the European Union’s Horizon 2020 FET Open project NanoTBTech (Grant Agreement No. 801305), the Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal under Project No. IMP18_38(2018/0265), and also COST action CA17140. Y.S. acknowledges a scholarship from the China Scholarship Council (No.201806870023), E.X. is grateful for a Juan de la Cierva Formación scholarship (No. FJC2018-036734-I), and D.H.O. is thankful to the Instituto de Salud Carlos III for a Sara Borrell Fellowship (No. CD17/00210). The authors thank Dr. Blanca del Rosal for the helpful discussion and input on the manuscrip

Relación de la personalidad y los factores de internalización y externalización en niños

Dotzenes Jornades de Foment de la Investigació de la FCHS (Any 2006-2007)Existe abundante literatura acerca del papel de la personalidad normal como factor de predisposición o de protección para el desarrollo y modulación de diferentes trastornos psicológicos tanto en adultos como en la infancia (Krueger y Tackett, 2003; Shiner y Caspi, 2003). Achenbach propuso dos síndromes generales de conductas anormales: el factror Externalizante (caracterizado por trastornos de conducta, conducta antisocial, agresividad verbal y búsqueda de atención) y el factor Internalizante (caracterizado por ansiedad, depresión, quejas somáticas y problemas de relación). Con respecto a la personalidad normal, el modelo más utilizado es el modelo de los cinco factores de Costa y McCrae (1992, 1999), que propone las dimensiones de Neuroticismo, Extraversión, Apertura a la experiencia, Amabilidad y Responsabilidad. El objetivo del actual estudio es explorar las relaciones entre la personalidad normal, según el modelo de los cinco factores, y los síndromes psicopatológicos de primer y segundo orden, propuestas por Achenbach en una muestra de niños de 11 a 13 años. Los resultados muestran una relación entre conductas psicopatológicas en niños y ciertos rasgos de personalidad: el Neuroticismo se asoció con el factor Internalizante y baja Responsabilidad y baja Amabilidad con el Factor Externalizante

Bismuth selenide nanostructured clusters as optical coherence tomography contrast agents: beyond gold-based particles

Optical coherence tomography (OCT) is an imaging technique currently used in clinical practice to obtain optical biopsies of different biological tissues in a minimally invasive way. Among the contrast agents proposed to increase the efficacy of this imaging method, gold nanoshells (GNSs) are the best performing ones. However, their preparation is generally time-consuming, and they are intrinsically costly to produce. Herein, we propose a more affordable alternative to these contrast agents: Bi2Se3 nanostructured clusters with a desert rose-like morphology prepared via a microwave-assisted method. The structures are prepared in a matter of minutes, feature strong near-infrared extinction properties, and are biocompatible. They also boast a photon-to-heat conversion efficiency of close to 50%, making them good candidates as photothermal therapy agents. In vitro studies evidence the prowess of Bi2Se3 clusters as OCT contrast agents and prove that their performance is comparable to that of GNSsJ.Y. acknowledges the support from the China Scholarship Council (CSC file no. 201704910867). R.M. acknowledges the support of the European Commission through the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 797945 (LANTERNS). This work was supported by the Spanish Ministry of Economy and Competitiveness under projects MAT2017-83111R, MAT2017-85617-R, and PID2019- 106211RB-I00, by the Instituto de Salud Carlos III (PI16/ 00812), by the Comunidad Autonoma de Madrid (B2017/ ́ BMD-3867 RENIM-CM), and cofinanced by the European Structural and Investment Fun

Eosin Y-functionalized upconverting nanoparticles: nanophotosensitizers and deep tissue bioimaging agents for simultaneous therapeutic and diagnostic applications

Functionalized upconverting nanoparticles (UCNPs) are promising theragnostic nanomaterials for simultaneous therapeutic and diagnostic purposes. We present two types of non-toxic eosin Y (EY) nanoconjugates derived from UCNPs as novel nanophotosensitizers (nano-PS) and deep-tissue bioimaging agents employing light at 800 nm. This excitation wavelength ensures minimum cell damage, since the absorption of water is negligible, and increases tissue penetration, enhancing the specificity of the photodynamic treatment (PDT). These UCNPs are uniquely qualified to fulfil three important roles: as nanocarriers, as energy-transfer materials, and as contrast agents. First, the UCNPs enable the transport of EY across the cell membrane of living HeLa cells that would not be possible otherwise. This cellular internalization facilitates the use of such EY-functionalized UCNPs as nano-PS and allows the generation of reactive oxygen species (ROS) under 800 nm light inside the cell. This becomes possible due to the upconversion and energy transfer processes within the UCNPs, circumventing the excitation of EY by green light, which is incompatible with deep tissue applications. Moreover, the functionalized UCNPs present deep tissue NIR-II fluorescence under 808 nm excitation, thus demonstrating their potential as bioimaging agents in the NIR-II biological windo

Time resolved confocal luminescence investigations on Reverse Proton Exchange Nd:LiNbO3 channel waveguides

This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OE.15.008805. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under la

Core-shell rare-earth-doped nanostructures in biomedicine

The current status of the use of core-shell rare-earth-doped nanoparticles in biomedical applications is reviewed in detail. The different core-shell rare-earth-doped nanoparticles developed so far are described and the most relevant examples of their application in imaging, sensing, and therapy are summarized. In addition, the advantages and disadvantages they present are discussed. Finally, a critical opinion of their potential application in real life biomedicine is givenThis work has been partially supported by the Ministerio de Economía y Competitividad de España (MINECO) (MAT2016-75362-C3-1-R), by the Instituto de Salud Carlos III (PI16/ 00812), by the Comunidad Autónoma de Madrid (B2017/ BMD-3867RENIM-CM), by the European Comission (NanoTBTech), and co-financed by European Structural and Investment Fund. This work has also been partially supported by COST action CM1403. L. L. P. thanks the Universidad Autónoma de Madrid for the “Formación de personal investi-gador (FPI-UAM)” program. P. R. S. thanks MINECO and the Fondo Social Europeo (FSE) for the “Promoción del talento y su Empleabilidad en I+D+i” statal program (BES-2014-069410). D. H. O. is grateful to the Instituto de Salud Carlos III for a Sara Borrell Fellowship (CD17/00210