Evaluación de la expresión de Ciclina D1, COX-2, Actina y Ki-67 en queratoquiste odontogénico, quiste odontogénico ortoqueratizado y ameloblastoma de los maxilares y sus implicaciones diagnósticas y patogénicas

Se propone realizar un estudio analizando la influencia de los cinco marcadores moleculares (MIB-1, Ciclina D1, COX-2, Actina, Calretinina) seleccionados, en el diagnóstico y patogenia de QQO, QOO y de AB. Se intenta demostrar si estos marcadores podrían ayudar a predecir futuras recurrencias y su comportamiento agresivo. Podrían ayudar en el proceso de decisión terapéutica en estos pacientes y contribuir a mejorar su postoperatorio y calidad de vida. Se ha demostrado que los QQOs/QOOs son entidades clinico-patológicas diferentes y que el QQO estaría más próximo al comportamiento de una neoplasia y no al de una lesión quística

Evaluación de la expresión de marcadores moleculares en tumores queratoquísticos odontogénicos (TQQOS) vs queratoquistes odontogénicos (QQOs) de los maxilares y sus implicaciones pronósticas y/o terapéuticas

Valorar las diferencias en los niveles de expresión entre los siguientes marcadores moleculares: Ciclina D1, COX-2, Calretinina, MF y MIB 1 (Ki-67), entre casos diagnosticados como TQQOs vs QOOs para valorar si se podrían utilizar en el diagnóstico diferencial de estas lesiones, en el pronóstico y el tratamiento. - Objetivo específico 1 (OE1): Valorar las posibles diferencias existentes entre ambas lesiones en relación a las variables epidemiológicas de la muestra analizada. - Objetivo específico 2 (OE2): Evaluar las diferencias entre la tasa de recurrencias del TQQO vs QOO relacionándolas con el tratamiento que recibieron en cada caso. - Objetivo específico 3 (OE3): Establecer si existen diferencias estadísticamente significativas en la expresión de los marcadores celulares en TQQO vs QOO. - Objetivo específico 4 (OE4): Evaluar las posibles diferencias de expresión en ambos grupos de lesiones y su posible relación con el tratamiento realizado y su pronóstico

Oral cancer, HPV infection and evidence of sexual transmission

The incidence of oropharyngeal cancer and oral cancer is growing worldwide, both in young non-smokers and in young non-drinkers (smoking and drinking are considered the main risk factors). Epidemiologic studies suggest a strong association between the infection by human papillomavirus (HPV), especially types 16 and 18 (high oncological risk) which have already demonstrated their etiological role in anal tumours as well as in cervix cancer. There is clear epidemiologic evidence that both types of tumours relate to changes in sexual behaviour and that both are linked to sexual transmission of HPV. The number of oral and oropharyngeal cancer cases is rising nowadays, especially among young individuals with no typical toxic habits, such as tobacco and/or alcohol. In this review we set out to update the aspects related to the onset of oral cancer, its relationship with HPV infection and whether this association may be due to the sexual transmission of the virus

A Latin American survey on demographic aspects of hospitalized, decompensated cirrhotic patients and the resources for their management

Introduction & objectives: Liver cirrhosis is a major cause of mortality worldwide. Adequate diagnosis and treatment of decompensating events requires of both medical skills and updated technical resources. The objectives of this study were to search the demographic profile of hospitalized cirrhotic patients in a group of Latin American hospitals and the availability of expertise/facilities for the diagnosis and therapy of decompensation episodes. Methods: A cross sectional, multicenter survey of hospitalized cirrhotic patients. Results: 377 patients, (62% males; 58 ± 11 years) (BMI > 25, 57%; diabetes 32%) were hospitalized at 65 centers (63 urbans; 57 academically affiliated) in 13 countries on the survey date. Main admission causes were ascites, gastrointestinal bleeding, hepatic encephalopathy and spontaneous bacterial peritonitis/other infections. Most prevalent etiologies were alcohol-related (AR) (40%); non-alcoholic-steatohepatitis (NASH) (23%), hepatitis C virus infection (HCV) (7%) and autoimmune hepatitis (AIH) (6%). The most frequent concurrent etiologies were AR + NASH. Expertise and resources in every analyzed issue were highly available among participating centers, mostly accomplishing valid guidelines. However, availability of these facilities was significantly higher at institutions located in areas with population > 500,000 (n = 45) and in those having a higher complexity level (Gastrointestinal, Liver and Internal Medicine Departments at the same hospital (n = 22). Conclusions: The epidemiological etiologic profile in hospitalized, decompensated cirrhotic patients in Latin America is similar to main contemporary emergent agents worldwide. Medical and technical resources are highly available, mostly at great population urban areas and high complexity medical centers. Main diagnostic and therapeutic approaches accomplish current guidelines recommendations

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data