9,232 research outputs found
Current perspectives of the signaling pathways directing neural crest induction.
The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body. Over the past two decades, an incredible amount of research has given us a reasonable understanding of how these cells are generated. Neural crest induction involves the combinatorial input of multiple signaling pathways and transcription factors, and is thought to occur in two phases from gastrulation to neurulation. In the first phase, FGF and Wnt signaling induce NC progenitors at the border of the neural plate, activating the expression of members of the Msx, Pax, and Zic families, among others. In the second phase, BMP, Wnt, and Notch signaling maintain these progenitors and bring about the expression of definitive NC markers including Snail2, FoxD3, and Sox9/10. In recent years, additional signaling molecules and modulators of these pathways have been uncovered, creating an increasingly complex regulatory network. In this work, we provide a comprehensive review of the major signaling pathways that participate in neural crest induction, with a focus on recent developments and current perspectives. We provide a simplified model of early neural crest development and stress similarities and differences between four major model organisms: Xenopus, chick, zebrafish, and mouse
X-ray spectral variability of seven LINER nuclei with XMM-Newton and Chandra data
One of the most important features in active galactic nuclei (AGN) is the
variability of their emission. Variability has been discovered at X-ray, UV,
and radio frequencies on time scales from hours to years. Among the AGN family
and according to theoretical studies, Low-Ionization Nuclear Emission Line
Region (LINER) nuclei would be variable objects on long time scales. Our
purpose is to investigate spectral X-ray variability in LINERs and to
understand the nature of these kinds of objects, as well as their accretion
mechanism. Chandra and XMM-Newton public archives were used to compile X-ray
spectra of seven LINER nuclei at different epochs with time scales of years. To
search for variability we fit all the spectra from the same object with a set
of models, in order to identify the parameters responsible for the variability
pattern. We also analyzed the light curves in order to search for short time
scale (from hours to days) variability. Whenever possible, UV variability was
also studied. We found spectral variability in four objects, with variations
mostly related to hard energies (2-10 keV). These variations are due to changes
in the soft excess, and/or changes in the absorber, and/or intrinsic variations
of the source. Another two galaxies seem not to vary. Short time scale
variations during individual observations were not found. Our analysis confirms
the previously reported anticorrelation between the X-ray spectral index and
the Eddington ratio, and also the correlation between the X-ray to UV flux
ratio and the Eddington ratio. These results support an Advection Dominated
Accretion Flow (ADAF) as the accretion mechanism in LINERs.Comment: 35 pages, 53 figures, recently accepted pape
X-ray spectral variability of Seyfert 2 galaxies
Variability across the electromagnetic spectrum is a property of AGN that can
help constraining the physical properties of these galaxies. This is the third
of a serie of papers with the aim of studying the X-ray variability of
different families of AGN. The main purpose of this work is to investigate the
variability pattern in a sample of optically selected type 2 Seyfert galaxies.
We use the 26 Seyferts in the Veron-Cetty and Veron catalogue with data
available from Chandra and/or XMM-Newton public archives at different epochs,
with timescales ranging from a few hours to years. All the spectra of the same
source are simultaneously fitted and we let different parameters to vary in the
model. Whenever possible, short-term variations and/or long-term UV flux
variations are studied. We divide the sample in Compton-thick, Compton-thin,
and changing-look candidates. Short-term variability at X-rays is not found.
From the 25 analyzed sources, 11 show long-term variations; eight (out of 11)
are Compton-thin, one (out of 12) is Compton-thick, and the two changing-look
candidates are also variable. The main driver for the X-ray changes is related
to the nuclear power (nine cases), while variations at soft energies or related
with absorbers at hard X-rays are less common, and in many cases these
variations are accompained with variations of the nuclear continuum. At UV
frequencies nuclear variations are nor found. We report for the first time two
changing-look candidates, MARK273 and NGC7319. A constant reflection component
located far away from the nucleus plus a variable nuclear continuum are able to
explain most of our results; the Compton-thick candidates are dominated by
reflection, which supresses their continuum making them seem fainter, and not
showing variations, while the Compton-thin and changing-look candidates show
variations.Comment: Accepted for publication in A&
X-ray spectral variability of LINERs selected from the Palomar sample
Variability is a general property of active galactic nuclei (AGN). At X-rays,
the way in which these changes occur is not yet clear. In the particular case
of low ionisation nuclear emission line region (LINER) nuclei, variations on
months/years timescales have been found for some objects, but the main driver
of these changes is still an open question. The main purpose of this work is to
investigate the X-ray variability in LINERs, including the main driver of such
variations, and to search for eventual differences between type 1 and 2
objects. We use the 18 LINERs in the Palomar sample with data retrieved from
Chandra and/or XMM-Newton archives corresponding to observations gathered at
different epochs. All the spectra for the same object are simultaneously fitted
in order to study long term variations. The nature of the variability patterns
are studied allowing different parameters to vary during the spectral fit.
Whenever possible, short term variations from the analysis of the light curves
and UV variability are studied.Comment: 49 pages, accepted. arXiv admin note: text overlap with
arXiv:1305.222
Abundant Z-cyanomethanimine in the interstellar medium: paving the way to the synthesis of adenine
We report the first detection in the interstellar medium of the Z-isomer of
cyanomethanimine (HNCHCN), an HCN dimer proposed as precursor of adenine. We
identified six transitions of Z-cyanomethanimine, along with five transitions
of E-cyanomethanimine, using IRAM 30m observations towards the Galactic Center
quiescent molecular cloud G+0.693. The Z-isomer has a column density of
(2.00.6)10 cm and an abundance of
1.510. The relative abundance ratio between the isomers is
[Z/E]6. This value cannot be explained by the two chemical formation
routes previously proposed (gas-phase and grain surface), which predicts
abundances ratios between 0.9 and 1.5. The observed [Z/E] ratio is in good
agreement with thermodynamic equilibrium at the gas kinetic temperature
(130210 K). Since isomerization is not possible in the ISM, the two species
may be formed at high temperature. New chemical models, including surface
chemistry on dust grains and gas-phase reactions, should be explored to explain
our findings. Whatever the formation mechanism, the high abundance of Z-HNCHCN
shows that precursors of adenine are efficiently formed in the ISM.Comment: Accepted in Monthly Notices of the Royal Astronomical Society Letter
Complex organic molecules in the Galactic Centre: the N-bearing family
We present an unbiased spectral line survey toward the Galactic Centre (GC)
quiescent giant molecular cloud (QGMC), G+0.693 using the GBT and IRAM 30
telescopes. Our study highlights an extremely rich organic inventory of
abundant amounts of nitrogen (N)-bearing species in a source without signatures
of star formation. We report the detection of 17 N-bearing species in this
source, of which 8 are complex organic molecules (COMs). A comparison of the
derived abundances relative to H is made across various galactic and
extragalactic environments. We conclude that the unique chemistry in this
source is likely to be dominated by low-velocity shocks with X-rays/cosmic rays
also playing an important role in the chemistry. Like previous findings
obtained for O-bearing molecules, our results for N-bearing species suggest a
more efficient hydrogenation of these species on dust grains in G+0.693 than in
hot cores in the Galactic disk, as a consequence of the low dust temperatures
coupled with energetic processing by X-ray/cosmic ray radiation in the GC.Comment: 24 pages, 23 figures, 7 tables, accepted for publication in MNRA
Hysteresis and Fractional Matching in Thin Nb Films with Rectangular Arrays of Nanoscaled Magnetic Dots
We have investigated the periodic pinning of magnetic flux quanta in thin Nb
films with rectangular arrays of magnetic dots. In this type of pinning
geometry, a change in the periodicity and shape of the minima in the
magnetoresistance occurs for magnetic fields exceeding a certain threshold
value. This has been explained recently in terms of a reconfiguration
transition of the vortex lattice due to an increasing vortex-vortex interaction
with increasing magnetic field. In this picture the dominating elastic energy
at high fields forces the vortex lattice to form a square symmetry rather than
being commensurate to the rectangular geometry of the pinning array. In this
paper we present a comparative study of rectangular arrays with Ni-dots,
Co-dots and holes. In the magnetic dot arrays, we found a strong fractional
matching effect up to the second order matching field. In contrast, no clear
fractional matching is seen after the reconfiguration. Additionally, we
discovered the existence of hysteresis in the magnetoresistance in the
crossover between the low and the high field regime. We found evidence that
this effect is correlated to the reconfiguration phenomenon rather than to the
magnetic state of the dots. The temperature and angular dependences of the
effect have been measured and possible models are discussed to explain this
behavior.Comment: 1 Table, 5 Figure
Order in driven vortex lattices in superconducting Nb films with nanostructured pinning potentials
Driven vortex lattices have been studied in a material with strong pinning,
such as Nb films. Samples in which natural random pinning coexists with
artificial ordered arrays of defects (submicrometric Ni dots) have been
fabricated with different geometries (square, triangular and rectangular).
Three different dynamic regimes are found: for low vortex velocities, there is
a plastic regime in which random defects frustrate the effect of the ordered
array; then, for vortex velocities in the range 1-100 m/s, there is a sudden
increase in the interaction between the vortex lattice and the ordered dot
array, independent on the geometry. This effect is associated to the onset of
quasi long range order in the vortex lattice leading to an increase in the
overlap between the vortex lattice and the magnetic dots array. Finally, at
larger velocities the ordered array-vortex lattice interaction is suppresed
again, in agreement with the behavior found in numerical simulations.Comment: 8 text pages + 4 figure
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