Development of canine rehabilitation and aquatic therapy

Information from research with animal models of immobilization and early motion following joint surgery drove human orthopedic surgeons to require physical therapy in their patients. This provided the basis for the physical therapy profession to be formed several decades ago. The same benefits of motion following joint surgery have not yet been explored in veterinary patients, as the first juvenile steps toward postoperative treatment have only been undertaken in the past few years. Few peer-reviewed manuscripts on rehabilitation in animals exist, and recommendations for the design and implementation of rehabilitation programs are nonexistent. This manuscript should serve as one of the first examples of how to establish a rehabilitation program for the dog. This is not an endpoint but rather the beginning. This serves to document the protocols and design of the Iowa State University, Veterinary Teaching Hospital, Canine Rehabilitation Center. This manuscript includes the design and implementation of this program, including but not limited to safety issues, water quality issues, patient care issues, and protocol recommendations. It also includes two of the first scientific reports submitted to peer-reviewed veterinary literature. The first, an evaluation of limb function comparing rehabilitation and traditional exercise-restriction after surgery for ruptured cranial cruciate ligaments, was accepted for publication by the Journal of the American Veterinary Medical Association. The other, a kinematic comparison of terrestrial and aquatic rehabilitation, has been submitted for publication. These scientific reports and this manuscript promote the use of aquatic rehabilitation for canine patients following a variety of orthopedic surgeries

Le débat au sein de la CSN sur l’organisation de la santé mentale

Les auteurs essaient de rendre compte, dans cet article, des enjeux de la politique en santé mentale en voie d'élaboration au sein de la C.S.N., et des débats que cela suscite dans cette centrale syndicale. Dans un premier temps, ils décrivent l'implication et le rôle des syndicats dans l'évolution de la psychiatrie au Québec au cours des dernières années. Ensuite, ils retracent les principaux événements qui ont mené aux interventions gouvernementales actuelles dans certaines institutions. Ils font par après le constat des faits suivants: l'ampleur des maladies mentales, la diversité des clientèles psychiatriques, la désinstitutionnalisation, la finalité des hôpitaux psychiatriques et les ressources alternatives. Ils finissent en exposant le point de vue de la C.S.N. sur diverses questions: la prévention, la réinsertion sociale, le travail, la désinstitutionnalisation et la réforme des hôpitaux psychiatriques.The authors attempt in this article, to account for the political stakes in mental health which are in process of elaboration, among the C.S.N., and the discussions they generate in this national union. They describe firstly the implication of the unions in Quebec during recent years. Secondly, they outline the main events that led to actual government interventions in certain institutions. Then they establish the following facts: the extent of mental sickness, the desinstitutionalisation, the finality of psychiatric hospitals and the alternative resources. Lastly, they disclose the C.S.N.'s point of view on various questions: prevention, social réintégration, work, desinstitutionalisation and psychiatric hospitals' reform

Enhancing foreign language learning through the integration of computer technology

This thesis demonstrates the effectiveness of using computer technology and the Internet to enhance classroom teaching. A variety of computer and internet based projects that complement lessons initiated by the classroom teacher provide real life situations for additional practice, reinforcement, motivation and greater student achievement

Supporting the construction of a professional identity

Titre de l'écran-titre (visionné le 22 avril 2009).Description et bilan d'une démarche d'orientation scolaire sur trois sessions entreprise au Cégep de Baie-Comeau dans le but d'aider les étudiants inscrits en sciences humaines à préciser leur choix universitaire et vocationnel; rappel des grands principes de l'école orientante

A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels

We recently reported the identification of a de novo single nucleotide variant in exon 9 of CACNA1C associated with prolonged repolarization interval. Recombinant expression of the glycine to arginine variant at position 419 produced a gain in the function of the L-type CaV1.2 channel with increased peak current density and activation gating but without signif- icant decrease in the inactivation kinetics. We herein reveal that these properties are replicated by overexpressing calmodulin (CaM) with CaV1.2 WT and are reversed by expo- sure to the CaM antagonist W-13. Phosphomimetic (T79D or S81D), but not phosphoresistant (T79A or S81A), CaM surro- gates reproduced the impact of CaM WT on the function of CaV1.2 WT. The increased channel activity of CaV1.2 WT following overexpression of CaM was found to arise in part from enhanced cell surface expression. In contrast, the prop- erties of the variant remained unaffected by any of these treatments. CaV1.2 substituted with the α-helix breaking pro- line residue were more reluctant to open than CaV1.2 WT but were upregulated by phosphomimetic CaM surrogates. Our results indicate that (1) CaM and its phosphomimetic analogs promote a gain in the function of CaV1.2 and (2) the structural properties of the first intracellular linker of CaV1.2 contribute to its CaM-induced modulation. We conclude that the CAC- NA1C clinical variant mimics the increased activity associated with the upregulation of CaV1.2 by Ca2+–CaM, thus main- taining a majority of channels in a constitutively active mode that could ultimately promote ventricular arrhythmias

Molecular and biochemical characterization of steroid sulfotransferases from Brassica napus and Arabidopsis thaliana

We describe the characterization of four genes designated BNST1 to - 4 encoding steroid sulfotransferases from Brassica napus . Recombinant BNST3 catalyzes the sulfonation of brassinosteroids and of mammalian estrogenic steroids. The enzyme is stereospecific for 24-epibrassinosteroids, with a substrate preference for 24-epicathasterone, a metabolic precursor of 24-epibrassinolide. The bean second internode bioassay was used to demonstrate that enzymatic sulfonation of 24-epibrassinolide abolishes its biological activity. This mechanism of hormone inactivation is similar to the modulation of estrogen biological activity observed in mammals. The sulfonation of an intermediate in the biosynthesis of 24-epibrassinolide may prevent the formation of biologically active end products. BNST genes are inducible by salicylic acid, a signal molecule in the defense response, suggesting that plants respond to pathogen infection by modulating steroid-dependent growth and developmental processes. BNST genes along with alcohol dehydrogenase ( ADH ) and xyloglucan endotransglycosylases ( XET ) genes are also inducible by ethanol. BNST4 displays the fastest response among BNST genes, with peak mRNA levels within one hour after treatment. Plants respond to low oxygen stress by a switch to ethanolic fermentation and the induction of anaerobic proteins, including ADH and XET. BNST proteins are induced under low oxygen stress, suggesting that endogenous ethanol may act as a chemical signal regulating gene expression. The localization of BNST2 and - 3 expression was studied in transgenic A. thaliana expressing promoter fusions with the Ý-glucoronidase reporter gene. Expression was observed at the apex of leaf organs, including cotyledons, rosette and cauline leaves. Expression was also observed in the transition zone of seedlings. The tissue distribution of expression is compatible with a function of the sulfotransferases in brassinosteroid inactivation. We tested this hypothesis in transgenic A. thaliana expressing BNST3 under the control of the constitutive CaMV35S promoter. No effect of the transgene was observed on plant growth and development, and the response of transgenic lines to exogenous 24-epiteasterone or 24-epibrassinolide was similar to that of the wild-type. Alternative experimental approaches will be required in order to determine the function of the sulfotransferases. The results of preliminary experiments performed in order to purify endogenous substrates of the BNST enzymes are discussed

Autour de Pierre Falardeau : found footage et réemploi d'images dans le cinéma politique

Ce mémoire portera sur le réemploi d’images dans le cinéma politique d’une manière générale dans un premier temps, puis plus spécifiquement dans l’oeuvre du cinéaste québécois Pierre Falardeau. Il s’agit donc d’abord de regarder comment, d’un point de vue historique, l’image fut réemployée dans le cinéma documentaire classique. Il sera ensuite question de la réutilisation de l’image à des fins politiques dans le cinéma expérimental à travers une analyse du found footage film. Dans un deuxième temps, nous verrons le réemploi d’images dans le cinéma militant, engagé politiquement (voire révolutionnaire) dans le cinéma d’Amérique latine (Santiago Alvarez, Fernando Solanas et Octavio Getino) et en France (Guy Debord, Chris Marker et Jean-Luc Godard). Par la suite, nous verrons comment Pierre Falardeau recyclera des images principalement dans trois de ses documentaires : Pea Soup, Speak White et Le temps des bouffons. Nous allons voir où il se situe dans les différentes traditions de réemploi d’images que nous avons vu précédemment et comment il se rapprochait et se distinguait de ses prédécesseurs.This thesis is concerned with the reuse of images in political cinema in general and, specifically, in the work of Quebec filmmaker Pierre Falardeau. We will first see how, from a historical point of view, archival images have been recycled in traditional documentary and then how they were used or reused for political purposes in found footage experimental films. We will then discuss the use of found footage in militant or revolutionary cinema both in Latin America (Santiago Alvarez, Fernando Solanas and Octavio Getino) and France (Guy Debord, Chris Marker and Jean-Luc Godard). We will then analyse Pierre Falardeau’s reuse of images in three of his documentaries: Pea Soup, Speak White and Le temps des bouffons. We will try and see how Falardeau fits within this tradition of the found footage film and the distinctive features of this aspect of his work