Discovery of a Dust Sorting Process on Boulders Near the Reiner Gamma Swirl on the Moon

In a database of lunar fractured boulders (Rüsch & Bickel, 2023, https://doi.org/10.3847/psj/acd1ef), we found boulders with reflectance features dissimilar to previously known morphologies. We performed a photo-geologic investigation and determined that the features correspond to a dust mantling on top of boulders with a unique photometric behavior. We next performed a photometric model inversion on the dust mantling using Bayesian inference sampling. Modeling indicates that the dust photometric anomaly is most likely due to a reduced opposition effect, whereas the single scattering albedo is not significantly different from that of the nearby background regolith. This implies a different structure of the dust mantling relative to the normal regolith. We identified and discussed several potential processes to explain the development of such soil. None of these mechanisms can entirely explain the multitude of observational constraints unless evoking anomalous boulder properties. Further study of these boulders can shed light on the workings of a natural dust sorting process potentially involving dust dynamics, a magnetic field, and electrostatic dust transport. The presence of these boulders appears to be limited to the Reiner K crater near the Reiner Gamma magnetic and photometric anomaly. This close spatial relationship further highlights that poorly understood processes occur in this specific region of the Moon

Clinical Correlates of Alzheimer's Disease with and without Silent Radiographic Abnormalities

Objective: To determine whether patients with Alzheimer's disease (AD) who do not have historical or clinical evidence of stroke but who do have computed tomographic or magnetic resonance imaging evidence of noncortical lesions smaller than 2 cm or periventricular "caps" differ from other patients with AD. Methods: The computed tomographic or magnetic resonance imaging scans of 158 patients meeting criteria of the National Institute of Neurological Disorders and Stroke—Alzheimer's Disease and Related Disorders Association for probable AD were reviewed by one neuroradiologist. Two measures of disease severity—the Modified Mini-Mental State examination and the Blessed Dementia Rating Scale (Part I)—were subjected to two-way analysis of variance with scan type (computed tomography or magnetic resonance imaging) and lesion number as between-group factors and age and disease duration as covariates. Results: No relationship was seen between lesion number or periventricular caps and disease severity. Conclusion: In this cross-sectional analysis using these clinical measures, patients with AD who have well-defined radiographic abnormalities cannot be differentiated from patients with AD who do not have them

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis

Message-specific translational control is required for gametogenesis. In yeast, the RNA-binding protein Rim4 mediates translational repression of numerous mRNAs, including the B-type cyclin CLB3, which is essential for establishing the meiotic chromosome segregation pattern. Here, we show that Rim4 forms amyloid-like aggregates and that it is the amyloid-like form of Rim4 that is the active, translationally repressive form of the protein. Our data further show that Rim4 aggregation is a developmentally regulated process. Starvation induces the conversion of monomeric Rim4 into amyloid-like aggregates, thereby activating the protein to bring about repression of translation. At the onset of meiosis II, Rim4 aggregates are abruptly degraded allowing translation to commence. Although amyloids are best known for their role in the etiology of diseases such as Alzheimer’s, Parkinson’s, and diabetes by forming toxic protein aggregates, our findings show that cells can utilize amyloid-like protein aggregates to function as central regulators of gametogenesis.Charles A. King Trust (Postdoctoral Fellowship)American Cancer Society (Fellowship)National Institutes of Health (U.S.) (Grants GM62207, GM77537, and GM094303

Comparison of three video laryngoscopy devices to direct laryngoscopy for intubating obese patients: a randomized controlled trial

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Salinity adaptation of the invasive New Zealand mud snail (Potamopyrgus antipodarum) in the Columbia River estuary (Pacific Northwest, USA): physiological and molecular studies

In this study, we examine salinity stress tolerances of two populations of the invasive species New Zealand mud snail Potamopyrgus antipodarum, one population from a high salinity environment in the Columbia River estuary and the other from a fresh water lake. In 1996, New Zealand mud snails were discovered in the tidal reaches of the Columbia River estuary that is routinely exposed to salinity at near full seawater concentrations. In contrast, in their native habitat and throughout its spread in the western US, New Zealand mud snails are found only in fresh water ecosystems. Our aim was to determine whether the Columbia River snails have become salt water adapted. Using a modification of the standard amphipod sediment toxicity test, salinity tolerance was tested using a range of concentrations up to undiluted seawater, and the snails were sampled for mortality at daily time points. Our results show that the Columbia River snails were more tolerant of acute salinity stress with the LC₅₀ values averaging 38 and 22 Practical Salinity Units for the Columbia River and freshwater snails, respectively. DNA sequence analysis and morphological comparisons of individuals representing each population indicate that they were all P. antipodarum. These results suggest that this species is salt water adaptable and in addition, this investigation helps elucidate the potential of this aquatic invasive organism to adapt to adverse environmental conditions.Keywords: Salinity, Gastropod, Invasive species, Columbia River, Mitochondrial DN

Multicenter Study of Predictors of Disease Course in Alzheimer Disease (the "Predictors Study"). I. Study Design, Cohort Description, and Intersite Comparisons

Clinicians should be able to provide the patient with Alzheimer disease (AD) and the family with an accurate prediction of what to expect, but the variability in the rate of disease progression precludes this. In several previous studies, specific clinical signs such as muscular rigidity, myoclonus, and hallucinations or delusions were associated with rapid progression to a more severe stage of dementia or death. The 'Predictors Study,' a longitudinal study at three independent sites, was designed to develop a predictor model of the natural history of Alzheimer disease. The study was conducted at three study sites, New York, Baltimore, and Boston in a cohort of 224 patients with early probable AD. This article describes the design and implementation of the Predictors Study, and compares features of the study cohort at baseline across sites. Patients were all at the mild stage of disease at entry and were relatively comparable across sites. Extrapyramidal signs and delusions were common, but myoclonus was rarely observed

Mapping recent shoreline changes spanning the lateral collapse of Anak Krakatau Volcano, Indonesia

We use satellite imagery to investigate the shoreline changes associated with volcanic activity in 2018–2019 at Anak Krakatau, Indonesia, spanning a major lateral collapse and period of regrowth through explosive activity. The shoreline changes have been analyzed and validated through the adaptation of an existing methodology based on Sentinel-2 multispectral imagery and developed on Google Earth Engine. This work tests the results of this method in a highly dynamic volcanic environment and validates them with manually digitized shorelines. The analysis shows that the size of the Anak Krakatau Island increased from 2.84 km2 to 3.19 km2 during 15 May 2018–1 November 2019 despite the loss of area in the 22 December 2018 lateral collapse. The lateral collapse reduced the island area to ~1.5 km2 but this was followed by a rapid increase in area in the first two months of 2019, reaching up to 3.27 km2. This was followed by a period of little change as volcanic activity declined and then by a net decrease from May 2019 to 1 November 2019 that resulted from erosion on the SW side of the island. This history of post-collapse eruptive regrowth and coastal erosion derived from the shoreline changes illuminates the potential for satellite-based automated shoreline mapping to provide databases for monitoring remote island volcanoes

The Nearby Evolved Stars Survey I. JCMT/SCUBA-2 Submillimeter Detection of the Detached Shell of U Antliae

We present the highest resolution single-dish submillimetre observations of the detached shell source U Antliae to date. The observations were obtained at 450 and 850m with SCUBA-2 instrument on the James Clerk Maxwell Telescope as part of the Nearby Evolved Stars Survey. The emission at 850m peaks at 40 arcsec with hints of a second peak seen at 20 arcsec. The emission can be traced out to a radius of 56 arcsec at a 3 level. The outer peak observed at 850m aligns well with the peak observed at Herschel/PACS wavelengths. With the help of spectral energy distribution fitting and radiative transfer calculations of multiple-shell models for the circumstellar envelope, we explore the various shell structures and the variation of grain sizes along the in the circumstellar envelope. We determine a total shell dust mass of (2.0 0.3) 105 M and established that the thermal pulse that gave rise to the detached shell occurred 3500 500 yr ago