Assessing the feasibility of a National InSAR Ground Deformation Map of Great Britain with Sentinel-1

This work assesses the feasibility of national ground deformation monitoring of Great Britain using synthetic aperture radar (SAR) imagery acquired by Copernicus’ Sentinel-1 constellation and interferometric SAR (InSAR) analyses. As of December 2016, the assessment reveals that, since May 2015, more than 250 interferometric wide (IW) swath products have been acquired on average every month by the constellation at regular revisit cycles for the entirety of Great Britain. A simulation of radar distortions (layover, foreshortening, and shadow) confirms that topographic constraints have a limited effect on SAR visibility of the landmass and, despite the predominance of rural land cover types, there is potential for over 22,000,000 intermittent small baseline subset (ISBAS) monitoring targets for each acquisition geometry (ascending and descending) using a set of IW image frames covering the entire landmass. Finally, InSAR results derived through ISBAS processing of the Doncaster area with an increasing amount of Sentinel-1 IW scenes reveal a consistent decrease of standard deviation of InSAR velocities from 6 mm/year to ≤2 mm/year. Such results can be integrated with geological and geohazard susceptibility data and provide key information to inform the government, other institutions and the public on the stability of the landmas

Using an agent-based model to analyze the dynamic communication network of the immune response

<p>Abstract</p> <p>Background</p> <p>The immune system behaves like a complex, dynamic network with interacting elements including leukocytes, cytokines, and chemokines. While the immune system is broadly distributed, leukocytes must communicate effectively to respond to a pathological challenge. The Basic Immune Simulator 2010 contains agents representing leukocytes and tissue cells, signals representing cytokines, chemokines, and pathogens, and virtual spaces representing organ tissue, lymphoid tissue, and blood. Agents interact dynamically in the compartments in response to infection of the virtual tissue. Agent behavior is imposed by logical rules derived from the scientific literature. The model captured the agent-to-agent contact history, and from this the network topology and the interactions resulting in successful versus failed viral clearance were identified. This model served to integrate existing knowledge and allowed us to examine the immune response from a novel perspective directed at exploiting complex dynamics, ultimately for the design of therapeutic interventions.</p> <p>Results</p> <p>Analyzing the evolution of agent-agent interactions at incremental time points from identical initial conditions revealed novel features of immune communication associated with successful and failed outcomes. There were fewer contacts between agents for simulations ending in viral elimination (<it>win</it>) versus persistent infection (<it>loss</it>), due to the removal of infected agents. However, early cellular interactions preceded successful clearance of infection. Specifically, more Dendritic Agent interactions with TCell and BCell Agents, and more BCell Agent interactions with TCell Agents early in the simulation were associated with the immune <it>win </it>outcome. The Dendritic Agents greatly influenced the outcome, confirming them as hub agents of the immune network. In addition, unexpectedly high frequencies of Dendritic Agent-self interactions occurred in the lymphoid compartment late in the <it>loss </it>outcomes.</p> <p>Conclusions</p> <p>An agent-based model capturing several key aspects of complex system dynamics was used to study the emergent properties of the immune response to viral infection. Specific patterns of interactions between leukocyte agents occurring early in the response significantly improved outcome. More interactions at later stages correlated with persistent inflammation and infection. These simulation experiments highlight the importance of commonly overlooked aspects of the immune response and provide insight into these processes at a resolution level exceeding the capabilities of current laboratory technologies.</p

Performance analysis for difficult airway equipment: Standardising for success

Airway management and intubation procedures continue to challenge anaesthetists. This design insight paper discusses the design development of an innovative tip pressure and shape retention testing system

G4-Quartet·M+Borate Hydrogels

The ability to modulate the physical properties of a supramolecular hydrogel may be beneficial for biomaterial and biomedical applications. We find that guanosine (G 1), when combined with 0.5 equiv of potassium borate, forms a strong, self-supporting hydrogel with elastic moduli >10 kPa. The countercation in the borate salt (MB(OH)4) significantly alters the physical properties of the hydrogel. The gelator combination of G 1 and KB(OH)4 formed the strongest hydrogel, while the weakest system was obtained with LiB(OH)4, as judged by 1H NMR and rheology. Data from powder XRD, 1H double-quantum solid-state magic-angle spinning (MAS) NMR and small-angle neutron scattering (SANS) were consistent with a structural model that involves formation of borate dimers and G4·K+ quartets by G 1 and KB(OH)4. Stacking of these G4·M+ quartets into G4-nanowires gives a hydrogel. We found that the M+ cation helps stabilize the anionic guanosine-borate (GB) diesters, as well as the G4-quartets. Supplementing the standard gelator mixture of G 1 and 0.5 equiv of KB(OH)4 with additional KCl or KNO3 increased the strength of the hydrogel. We found that thioflavin T fluoresces in the presence of G4·M+ precursor structures. This fluorescence response for thioflavin T was the greatest for the K+ GB system, presumably due to the enhanced interaction of the dye with the more stable G4·K+ quartets. The fluorescence of thioflavin T increased as a function of gelator concentration with an increase that correlated with the system’s gel point, as measured by solution viscosit

An agenda for future research regarding the mental health of young people with care experience

Young people who are currently or were previously in state care have consistently been found to have much higher rates of mental health and neurodevelopmental difficulties than the general youth population. While a number of high-quality reviews highlight what research has been undertaken in relation to the mental health of young people with care experience and the gaps in our knowledge and understanding, there is, until now, no consensus, so far as we aware, as to where our collective research efforts should be directed with this important group. Through a series of UK wide workshops, we undertook a consultative process to identify an agreed research agenda between those with lived experience of being in care (n = 15), practitioners, policy makers and researchers (n = 59), for future research regarding the mental health of young people with care experience, including those who are neurodiverse/have a neurodevelopmental difficulty. This consensus statement identified 21 foci within four broad categories: how we conceptualize mental health; under-studied populations; under-studied topics; and underused methodologies. We hope that those who commission, fund and undertake research will engage in this discussion about the future agenda for research regarding the mental health of young people with care experience

Modelling groundwater rebound in recently abandoned coalfields using DInSAR

Advances in differential interferometric synthetic aperture radar (DInSAR) processing algorithms, such as the Intermittent Small Baseline Subset (ISBAS), and increased data availability from SAR systems, such as Sentinel-1, provide the opportunity to increase the spatial and temporal density of ground deformation measurements. Such measurements, when combined with modelling, have the potential to make a significant cost-effective contribution to the progressive abandonment strategy of recently closed coalfields. Applications of DInSAR over coalfields have observed heave in coal measures rocks and temporal correlations between the rise of mine water and deformation time-series. The cessation of systematic dewatering can have a variety of detrimental impacts and knowledge of the time-scales (i.e. the rate of rebound) and structure of the mine system are crucial to the remediation strategy. Although mine plans and borehole measurements provide vital information in this regard, mine plans are often incomplete or inaccurate, whereas monitoring boreholes are spatially sparse. Consequently, groundwater can flow in unanticipated directions via goaf, mine shafts and roadways, making it difficult to determine where the impacts of rebound are likely to occur. In this study, ground deformation data obtained using ISBAS DInSAR on ENVISAT (2002–2009) and Sentinel-1 (2015–2019) data are used to develop a simple method to model groundwater rebound in abandoned coalfields. A forward analytical model based upon the principle of effective stress and mine water ponds is first implemented to estimate surface heave in response to changes in groundwater levels measured in monitoring boreholes. The forward model is then calibrated and validated using the ground deformation data. The DInSAR data were subsequently inverted to map the change in groundwater levels in greater detail across the coalfield and forecast surface discharges in order to support mitigation strategies

The Third wave in globalization theory

This essay examines a proposition made in the literature that there are three waves in globalization theory—the globalist, skeptical, and postskeptical or transformational waves—and argues that this division requires a new look. The essay is a critique of the third of these waves and its relationship with the second wave. Contributors to the third wave not only defend the idea of globalization from criticism by the skeptics but also try to construct a more complex and qualified theory of globalization than provided by first-wave accounts. The argument made here is that third-wave authors come to conclusions that try to defend globalization yet include qualifications that in practice reaffirm skeptical claims. This feature of the literature has been overlooked in debates and the aim of this essay is to revisit the literature and identify as well as discuss this problem. Such a presentation has political implications. Third wavers propose globalist cosmopolitan democracy when the substance of their arguments does more in practice to bolster the skeptical view of politics based on inequality and conflict, nation-states and regional blocs, and alliances of common interest or ideology rather than cosmopolitan global structures

Risk of winter hospitalisation and death from acute respiratory infections in Scotland: national retrospective cohort study

Objectives We undertook a national analysis to characterise and identify risk factors for acute respiratory infections (ARIs) resulting in hospitalisation and death during the winter period in Scotland. Design A population-based retrospective cohort analysis Setting Scotland Participants 5.4 million residents in Scotland Main outcome measures Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CIs) for the association between risk factors and ARI hospitalisation. Results Between September 1, 2022 and January 31, 2023, there were 22,284 (10.9% of 203,549 with any emergency hospitalisation) ARI hospitalisations (1,759 in children and 20,525 in adults) in Scotland. Compared to the reference group of children aged 6-17 years, the risk of ARI hospitalisation was higher in children aged 3-5 years (aHR=4.55 95%CI (4.11-5.04)). Compared to 25-29 years old, the risk of ARI hospitalisation was highest amongst the oldest adults aged ≥80 years (7.86 (7.06-8.76)). Adults from more deprived areas (most deprived vs least deprived, 1.64 (1.57-1.72)), with existing health conditions (≥5 vs 0 health conditions, 4.84 (4.53-5.18)) or with history of all-cause emergency admissions (≥6 vs 0 previous emergency admissions 7.53 (5.48-10.35)) were at higher risk of ARI hospitalisations. The risk increased by the number of existing health conditions and previous emergency admission. Similar associations were seen in children. Conclusions Younger children, older adults, those from more deprived backgrounds and individuals with greater numbers of pre-existing conditions and previous emergency admission were at increased risk for winter hospitalisations for ARI