322 research outputs found
Characterisation of slip and twin activity using digital image correlation and crystal plasticity finite element simulation:Application to orthorhombic -uranium
Calibrating and verifying crystal plasticity material models is a significant
challenge, particularly for materials with a number of potential slip and twin
systems. Here we use digital image correlation on coarse-grained
-uranium during tensile testing in conjunction with crystal plasticity
finite element simulations. This approach allows us to determine the critical
resolved shear stress, and hardening rate of the different slip and twin
systems. The constitutive model is based on dislocation densities as state
variables and the simulated geometry is constructed from electron backscatter
diffraction images that provide shape, size and orientation of the grains,
allowing a direct comparison between virtual and real experiments. An
optimisation algorithm is used to find the model parameters that reproduce the
evolution of the average strain in each grain as the load is increased. A
tensile bar, containing four grains aligned with the load direction, is used to
calibrate the model with eight unknown parameters. The approach is then
independently validated by simulating the strain distribution in a second
tensile bar. Different mechanisms for the hardening of the twin systems are
evaluated. The latent hardening of the most active twin system turns out to be
determined by coplanar twins and slip. The hardening rate of the most active
slip system is lower than in fine-grained -uranium. The method
developed in the present research can be applied to identify the critical
resolved shear stress and hardening parameters of other coarse-grained
materials
Contact processes with long-range interactions
A class of non-local contact processes is introduced and studied using
mean-field approximation and numerical simulations. In these processes
particles are created at a rate which decays algebraically with the distance
from the nearest particle. It is found that the transition into the absorbing
state is continuous and is characterized by continuously varying critical
exponents. This model differs from the previously studied non-local directed
percolation model, where particles are created by unrestricted Levy flights. It
is motivated by recent studies of non-equilibrium wetting indicating that this
type of non-local processes play a role in the unbinding transition. Other
non-local processes which have been suggested to exist within the context of
wetting are considered as well.Comment: Accepted with minor revisions by Journal of Statistical Mechanics:
Theory and experiment
In situ observation of compressive deformation of an interconnected network of zinc oxide tetrapods
Zinc oxide tetrapods have remarkable functional and mechanical properties with potential applications in different fields including nanoelectronic and optoelectronic sensing, functional composites and coatings, as well as energy harvesting and storage. Based on the 3D shape of these microparticles, they can be assembled into highly porous (up to 98%) macroscopic ceramic framework structures that can be utilized as a versatile template for the fabrication of other multi-scaled foam-like materials. Here we investigated the three-dimensional structure of low density interconnected zinc oxide tetrapod networks by high resolution X-ray computed tomography. In situ observations during mechanical loading show inhomogeneous development of anelastic strain (damage) during compression, and homogeneous elastic recovery on unloading. Individual tetrapods are observed to deform by arm rotation to accommodate strain
Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties
The cortex of the femoral neck is a key structural element of the human body, yet there is not a reliable metric for predicting the mechanical properties of the bone in this critical region. This study explored the use of a range of non-destructive metrics to measure femoral neck cortical bone stiffness at the millimetre length scale. A range of testing methods and imaging techniques were assessed for their ability to measure or predict the mechanical properties of cortical bone samples obtained from the femoral neck of hip replacement patients. Techniques that can potentially be applied in vivo to measure bone stiffness, including computed tomography (CT), bulk wave ultrasound (BWUS) and indentation, were compared against in vitro techniques, including compression testing, density measurements and resonant ultrasound spectroscopy. Porosity, as measured by micro-CT, correlated with femoral neck cortical boneâs elastic modulus and ultimate compressive strength at the millimetre length scale. Large-tip spherical indentation also correlated with bone mechanical properties at this length scale but to a lesser extent. As the elastic mechanical properties of cortical bone correlated with porosity, we would recommend further development of technologies that can safely measure cortical porosity in vivo. Introductio
Individual quality assessment of autografting by probability estimation for clinical endpoints: a prospective validation study from the European group for blood and marrow transplantation.
The aim of supportive autografting is to reduce the side effects from stem cell transplantation and avoid procedure-related health disadvantages for patients at the lowest possible cost and resource expenditure. Economic evaluation of health care is becoming increasingly important. We report clinical and laboratory data collected from 397 consecutive adult patients (173 non-Hodgkin lymphoma, 30 Hodgkin lymphoma, 160 multiple myeloma, 7 autoimmune diseases, and 28 acute leukemia) who underwent their first autologous peripheral blood stem cell transplantation (PBSCT). We considered primary endpoints evaluating health economic efficacy (eg, antibiotic administration, transfusion of blood components, and time in hospital), secondary endpoints evaluating toxicity (in accordance with Common Toxicity Criteria), and tertiary endpoints evaluating safety (ie, the risk of regimen-related death or disease progression within the first year after PBSCT). A time-dependent grading of efficacy is proposed with day 21 for multiple myeloma and day 25 for the other disease categories (depending on the length of the conditioning regimen) as the acceptable maximum time in hospital, which together with antibiotics, antifungal, or transfusion therapy delineates four groups: favorable (â€7 days on antibiotics and no transfusions; â€21 [25] days in hospital), intermediate (from 7 to 10 days on antibiotics and 7 days on antibiotics, >3 but 30/34 days in hospital after transplantation), and very unfavorable (>10 days on antibiotics, >6 transfusions; >30 to 34 days in hospital). The multivariate analysis showed that (1) PBSC harvests of â„4 Ă 106/kg CD34 + cells in 1 apheresis procedure were associated with a favorable outcome in all patient categories except acute myelogenous leukemia and acute lymphoblastic leukemia (P = .001), (2) â„5 Ă 106/kg CD34 + cells infused predicted better transplantation outcome in all patient categories (P 500 mL) (P = .002), and (5) patients with a central venous catheter during both collection and infusion of PBSC had a more favorable outcome post-PBSCT than peripheral access (P = .007). The type of mobilization regimen did not affect the outcome of auto-PBSCT. The present study identified predictive variables, which may be useful in future individual pretransplantation probability evaluations with the goal to improve supportive care
Polymorphic evolution sequence and evolutionary branching
We are interested in the study of models describing the evolution of a
polymorphic population with mutation and selection in the specific scales of
the biological framework of adaptive dynamics. The population size is assumed
to be large and the mutation rate small. We prove that under a good combination
of these two scales, the population process is approximated in the long time
scale of mutations by a Markov pure jump process describing the successive
trait equilibria of the population. This process, which generalizes the
so-called trait substitution sequence, is called polymorphic evolution
sequence. Then we introduce a scaling of the size of mutations and we study the
polymorphic evolution sequence in the limit of small mutations. From this study
in the neighborhood of evolutionary singularities, we obtain a full
mathematical justification of a heuristic criterion for the phenomenon of
evolutionary branching. To this end we finely analyze the asymptotic behavior
of 3-dimensional competitive Lotka-Volterra systems
Coherent state of a nonlinear oscillator and its revival dynamics
The coherent state of a nonlinear oscillator having a nonlinear spectrum is
constructed using Gazeau Klauder formalism. The weighting distribution and the
Mandel parameter are studied. Details of the revival structure arising from
different time scales underlying the quadratic energy spectrum are investigated
by the phase analysis of the autocorrelation function
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