Corpo estranho linear em felino- relato de caso / Linear foreign body in cat- a case report

Apesar do hábito alimentar seletivo dos felinos, a maior incidência de corpo estranho linear acontece em gatos, devido ao seu comportamento em brincar com novelos de lã, panos, e linhas em geral. O corpo estranho linear é considerado uma emergência cirúrgica, a sintomatologia clinica é grave, em alguns casos até óbito. Os sinais clínicos mais comuns são anorexia, vômito, letargia, febre e dor abdominal, dispneia, inquietação e caquexia. O diagnóstico é realizado através do histórico clínico e avaliação físico, radiografias simples ou contrastado e ecografia abdominal. Para tratamento na maioria das vezes é cirúrgico. Relata-se o caso de um felino, fêmea, siamês, de um ano e dois meses de idade com êmese há dez dias e dor à palpação abdominal, desidratado e apático. Na inspeção da cavidade oral encontrou-se o corpo estranho linear preso à região de frênulo lingual. Ao exame radiográfico abdominal, notou-se leve pregueamento de alças intestinais. Realizou-se a gastrotomia, enterectomia e varias enterorrafias devido a perfuração intestinal. Realizou-se a retirada de pontos após 15 dias do procedimento cirúrgico e animal apresentou-se em ótimo estado

Interference of the nandrolona decanoate associated with stell cells in bone consolidation of osteotomy defect for advanced tibial tuberosity in dogs

Muitos estudos vem sendo realizados para acelerar o processo de consolidação óssea para diminuir o tempo de tratamento, custos e o retorno precoce do membro. As células tronco são células com capacidade de proliferação, autorrenovação, produção de diferentes linhagens celulares e regeneração de tecidos. As células tronco resultam em diferenciação e proliferação de osteoclastos e condrócitos, levando a diminuição no tempo de consolidação óssea. O decanoato de nandrolona estimula a proliferação dos osteoblastos, diminuição dos osteoclastos e estimulação do hormônio de crescimento levando a diminuição no tempo de consolidação óssea. O avanço da tuberosidade tibial permite a criação de uma falha homogênea, a qual é utilizada como modelo de estudo da consolidação óssea em cães. Objetivou-se comparar o tempo de consolidação do defeito gerado pelo avanço da tuberosidade tibial com o uso de células tronco associadas ou não com decanoato de nandrolona em cães com diagnóstico de ruptura do ligamento cruzado cranial. O trabalho dividiu-se em 4 grupos de seis animais cada: C (controle), CT (células tronco), CTDN (células tronco associado com decanoato de nandrolona) e DN (decanoato de nandrolona). O CTDN apresentou-se com o menor tempo de consolidação óssea. Ao comparar os tempos de consolidação entre os grupos houve diferenças estatisticamente significativas (P<0,001). A diferença esteve localizada entre os grupos controle (Grupo C) e decanoato de nandrolona (Grupo DN) (84 versus 63 dias, P=0,034) e entre os grupos controle (Grupo C) e decanoato de nandrolona associado com aplicação de células tronco na falha óssea (Grupo CTDN). (84 versus 42, P<0,001). A associação de CT e DN diminuiu o tempo de consolidação óssea em pacientes que realizaram TTA.There have been many studies on bone healing trying to reduce treatment time, costs and promote early return of limb function. Stem cells have a number of characteristics that are useful for the healing process: proliferation, self-renewal, production of different cell lines and tissue regeneration. Nuclear stem cells result in osteoclast and chondrocyte differentiation and proliferation, leading to decreased bone healing time. Nandrolone decanoate stimulates osteoblast proliferation, osteoclast shrinkage and growth hormone stimulation leading to decreased bone healing time. Tibial tuberosity advancement surgery (TTA) creates a standardized bone defect which can be used as a model for bone healing in dogs. This study investigated the effect on time taken to consolidate the TTA defect of stem cell application and nandrolone decanoate treatment in dogs treated for cranial cruciate ligament rupture. Dogs were divided into 4 groups of six animals each receiving a different treatment post-surgery: C (control), CT (stem cells), CTDN (stem cells and nandrolone decanoate) and DN (nandrolone decanoate). There were statistically significant differences (P<0,001) in consolidation times between the control group (Group C) and nandrolone decanoate (DN) (84 versus 63 days, P = 0.034) and between the control groups (Group C) and nandrolone decanoate and stem cells (CTDN) (84 versus 42, P<0,001). The combination of CT and DN decreased bone healing time in dogs undergoing TTA surgery

Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19

Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use